Wiley Interdisciplinary Reviews Nanomedicine and Nanobiotechnology,
Год журнала:
2024,
Номер
16(3)
Опубликована: Май 1, 2024
Abstract
The
misuse
of
antibiotics
has
led
to
increased
bacterial
resistance,
posing
a
global
public
health
crisis
and
seriously
endangering
lives.
Currently,
antibiotic
therapy
remains
the
most
common
approach
for
treating
infections,
but
its
effectiveness
against
multidrug‐resistant
bacteria
is
diminishing
due
slow
development
new
increase
drug
resistance.
Consequently,
developing
a\ntimicrobial
strategies
improving
efficacy
combat
infection
become
an
urgent
priority.
emergence
nanotechnology
revolutionized
traditional
treatment,
presenting
opportunities
refractory
infection.
Here
we
comprehensively
review
research
progress
in
nanotechnology‐based
antimicrobial
delivery
highlight
diverse
platforms
designed
target
different
resistance
mechanisms.
We
also
outline
use
combining
with
other
therapeutic
modalities
enhance
drug‐resistant
infections.
These
innovative
have
potential
susceptibility
overcome
Finally,
challenges
prospects
application
nanomaterial‐based
combating
are
discussed.
This
article
categorized
under:
Biology‐Inspired
Nanomaterials
>
Nucleic
Acid‐Based
Structures
Therapeutic
Approaches
Drug
Discovery
Nanomedicine
Infectious
Disease
Journal of Materials Chemistry B,
Год журнала:
2023,
Номер
11(29), С. 6746 - 6761
Опубликована: Янв. 1, 2023
The
slow
healing
of
diabetic
wounds
has
seriously
affected
human
health.
Meanwhile,
the
open
are
susceptible
to
bacterial
infection.
Clinical
therapeutic
methods
such
as
antibiotic
therapy,
insulin
treatment,
and
surgical
debridement
have
made
great
achievements
in
treatment
wounds.
However,
drug-resistant
bacteria
will
develop
after
long-term
use
antibiotics,
resulting
decreased
efficacy.
To
improve
effect,
increasing
drug
concentration
is
a
common
strategy
clinical
practice,
but
it
also
brings
serious
side
effects.
In
addition,
hyperglycemia
control
or
can
easily
bring
negative
effects
patients,
hypoglycemia
damage
normal
tissue.
Therefore,
essential
novel
strategies
effectively
promote
wound
healing.
recent
years,
nanozyme-based
systems
received
extensive
attention
because
they
possess
advantages
nanomaterials
natural
enzymes.
For
example,
nanozymes
small
size
high
surface
area
volume
ratio,
which
enhance
tissue
penetration
increase
reactive
active
sites.
Moreover,
compared
with
enzymes,
more
stable
catalytic
activity,
lower
production
cost,
stronger
operability.
this
review,
we
first
reviewed
basic
characteristics
then
elaborated
on
mechanism
action
principle
different
types
from
three
aspects:
controlling
infection,
hyperglycemia,
relieving
inflammation.
Finally,
challenges,
prospects
future
implementation
for
outlined.
Advanced Healthcare Materials,
Год журнала:
2023,
Номер
12(26)
Опубликована: Май 15, 2023
Abstract
The
application
of
medical
implants
has
greatly
improved
the
survival
rate
and
life
quality
patients.
Nevertheless,
in
recent
years,
there
are
increasing
cases
implant
dysfunction
or
failure
because
bacterial
infections.
Despite
significant
improvements
biomedicine,
still
serious
challenges
treatment
implant‐related
With
formation
biofilms
development
resistance,
these
limitations
lead
to
a
low
efficacy
conventional
antibiotics.
To
address
challenges,
it
is
urgent
exploit
innovative
strategies
for
Based
on
ideas,
environment‐responsive
therapeutic
platforms
with
high
selectivity,
drug
minor
dose‐limiting
toxicity
have
attracted
widespread
attention.
By
using
exogenous/endogenous
stimuli,
antibacterial
activity
therapeutics
can
be
activated
demand
exhibit
remarkable
effects.
Exogenous
stimuli
include
photo,
magnetism,
microwave,
ultrasound.
Endogenous
mainly
pathological
characteristics
infections
such
as
acidic
pH,
anomalous
temperature,
abnormal
enzymatic
activities.
In
this
review,
progress
spatiotemporally
controlled
release/activation
systematically
summarized.
Afterward,
opportunities
emerging
highlighted.
Finally,
hoped
that
review
will
offer
novel
ideas
techniques
combat
ACS Nano,
Год журнала:
2023,
Номер
17(11), С. 10019 - 10032
Опубликована: Май 26, 2023
Inhibition
of
quorum
sensing
(QS)
is
considered
as
an
effective
strategy
in
combatting
biofilm-associated
bacterial
infections.
However,
the
application
inhibitors
(QSI)
strongly
restricted
by
poor
water-solubility
and
low
bioavailability.
We
herein
fabricate
pH-sensitive
curcumin
(Cur)
loaded
clustered
nanoparticles
with
active
targeting
ability
(denoted
anti-CD54@Cur-DA
NPs)
to
inhibit
QS
for
enhanced
antibiotic
therapy.
Cur-DA
NPs
are
first
prepared
through
electrostatic
interaction
between
Cur
amino-ended
poly(amidoamine)
dendrimer
(PAMAM)
2,3-dimethyl
maleic
anhydride
(DA)
modified
biotin-poly(ethylene
glycol)-polylysine
(biotin-PEG-PLys).
Anti-CD54@Cur-DA
then
obtained
modification
anti-CD54.
PAMAM
can
be
released
from
acidic
pH,
leading
simultaneous
charge
reversal
size
decrease,
which
beneficial
biofilm
penetration.
hence
much
better
inhibiting
than
free
due
Compared
Cur,
exhibit
stronger
capability
development
architecture
maturation,
thus
downregulating
efflux
pump-related
genes
improving
bactericidal
performance
multiple
antibiotics,
including
Penicillin
G,
ciprofloxacin,
tobramycin.
Moreover,
since
anti-CD54
selectively
bind
inflamed
endothelial
cells,
targeted
accumulated
bacteria-infected
tissues.
The
sequential
treatment
using
antibiotics
effectively
reduce
burden
alleviate
inflammation
a
chronic
lung
infection
model
vivo.
This
research
provides
way
improve
therapeutic
QSI
enhance
anti-biofilm
effects
radiate
vitality
conventional
treating
Biomaterials Research,
Год журнала:
2023,
Номер
27(1)
Опубликована: Фев. 9, 2023
The
advent
of
drug-resistant
pathogens
results
in
the
occurrence
stubborn
bacterial
infections
that
cannot
be
treated
with
traditional
antibiotics.
Antibacterial
immunotherapy
by
reviving
or
activating
body's
immune
system
to
eliminate
pathogenic
bacteria
has
confirmed
promising
therapeutic
strategies
controlling
infections.
Subsequent
studies
found
antimicrobial
its
own
benefits
and
limitations,
such
as
avoiding
recurrence
infection
autoimmunity-induced
side
effects.
Current
indicate
various
antibacterial
inducing
regulation
can
achieve
superior
efficacy
compared
monotherapy
alone.
Therefore,
summarizing
recent
advances
nanomedicine
immunomodulatory
functions
for
combating
is
necessary.
Herein,
we
briefly
introduce
crisis
caused
opportunity
immunotherapy.
Then,
immune-involved
multimodal
therapy
treatment
infectious
diseases
was
systematically
summarized.
Finally,
prospects
challenges
combinational
are
discussed.
Materials & Design,
Год журнала:
2023,
Номер
229, С. 111927 - 111927
Опубликована: Апрель 8, 2023
The
development
of
functional
wound
dressings
capable
both
rapid
hemostasis
and
high-efficiency
antimicrobial
is
essential
for
the
management
severe
bleeding
wounds.
Cotton
are
widely
used
in
clinical
practice;
however,
few
can
simultaneously
achieve
high-efficacy
antimicrobial.
Herein,
a
versatile
cotton
dressing
(GCQCNF-5)
was
masterly
developed
by
sequentially
deposition
catechol
modified
quaternary
chitosan
(CQCS)
gelatin
onto
nonwoven
fabric
(NF)
surface.
Because
presence
sponge
layer
with
suitable
thickness
porosity
on
its
surface,
GCQCNF-5
exhibits
notably
enhanced
hemostatic
effect
compared
to
NF
vitro
vivo,
which
even
slightly
superior
that
MHS
(a
commercial
sponge).
Moreover,
after
exerting
effect,
further
exploit
CQCS
exert
excellent
immediate
long-lasting
bacteriostatic
effects.
In
vivo
healing
experiments
indicated
could
significantly
promote
infected
wounds
effectively
sterilizing,
absorbing
exudates,
providing
moist
environments.
This
study
clearly
demonstrated
hemostasis,
antimicrobial,
wounds,
great
application
potential
treatment
Advanced Materials,
Год журнала:
2023,
Номер
35(52)
Опубликована: Ноя. 17, 2023
Stubborn
biofilm
infections
pose
serious
threats
to
human
health
due
the
persistence,
recurrence,
and
dramatically
magnified
antibiotic
resistance.
Photodynamic
therapy
has
emerged
as
a
promising
approach
combat
biofilm.
Nevertheless,
how
inhibit
bacterial
signal
transduction
system
efflux
pump
conquer
recurrence
resistance
remains
challenging
unaddressed
issue.
Herein,
boric
acid-functionalized
lipophilic
cationic
type
I
photosensitizer,
ACR-DMP,
is
developed,
which
efficiently
generates
•OH
overcome
hypoxic
microenvironment
photodynamically
eradicates
methicillin-resistant
Staphylococcus
aureus
(MRSA)
biofilms.
Furthermore,
it
not
only
alters
membrane
potential
homeostasis
osmotic
pressure
balance
its
strong
binding
ability
with
plasma
but
also
inhibits
quorum
sensing
two-component
system,
reduces
virulence
factors,
regulates
activity
of
drug
attributed
glycan-targeting
ability,
helping
prevent
In
vivo,
ACR-DMP
successfully
obliterates
MRSA
biofilms
attached
implanted
medical
catheters,
alleviates
inflammation,
promotes
vascularization,
thereby
combating
accelerating
wound
healing.
This
work
provides
an
efficient
strategy
stubborn
multidrug
offers
systematic
guidance
for
rational
design
next-generation
advanced
antimicrobial
materials.
Heliyon,
Год журнала:
2023,
Номер
9(11), С. e22105 - e22105
Опубликована: Ноя. 1, 2023
With
the
wide
spread
of
Multidrug-resistant
bacteria
(MDR)
due
to
transfer
and
acquisition
antibiotic
resistance
genes
formation
microbial
biofilm,
various
researchers
around
world
are
looking
for
a
solution
overcome
these
resistances.
One
potential
strategy
best
candidate
infections
is
using
an
effective
nanomaterial
with
antibacterial
properties
against
them.
analysis:
In
this
study,
we
overview
nanomaterials
anti-MDR
anti-biofilm
properties.
Hence,
systematically
explored
biomedical
databases
(Web
Sciences,
Google
Scholar,
PubMed,
Scopus)
categorize
related
studies
about
activities
from
2007
December
2022.
total,
forty-one
were
investigated
find
information
during
2007-2022.
According
collected
documents,
nineteen
types
showed
putative
effects
such
as
Cu,
Ag,
Au,
Au/Pt,
TiO2,
Al2O3,
ZnO,
Se,
CuO,
Cu/Ni,
Cu/Zn,
Fe3O4,
Au/Fe3O4,
Au/Ag,
Graphene
O,
CuS.
addition,
seven
them
considered
agents
Au/Ag.
studies,
each
has
been
designed
different
methods
their
standard
strains,
clinical
MDR
bacterial
biofilms
have
in-vitro
in-vivo
conditions.
destructive
mechanism
on
structures.
Various
nanoparticles
(NP)
introduced
designing
new
drug
medical
equipment
preventing
infectious
disease
outbreaks
by
biofilm.
Advanced Healthcare Materials,
Год журнала:
2023,
Номер
12(29)
Опубликована: Июль 29, 2023
The
presence
of
a
biofilm
matrix
barrier
and
hypoxic
microenvironment
within
the
significantly
impedes
efficacy
photodynamic
therapy
for
bacterial
infections.
Herein,
phototherapeutic
nanoagent
with
type-I
behavior
nitric
oxide
(NO)
release
performance
is
reported
overcoming
biofilm-associated
infectious
diseases.
Sodium
nitroprusside
(SNP),
NO
donor,
loaded
onto
amino-modified
mesoporous
silica
nanoparticles
(MSN)
to
form
MSN@SNP
NPs.
resulting
are
further
modified
porphyrin-based
metal-organic
framework
(Ti-TCPP
MOF)
obtain
MSN@MOF/SNP
NPs
(MMS
NPs)
applications.
In
hypoxia
microenvironment,
MMS
enhance
permeability
induce
generation
hydroxyl
radical
(•OH)
superoxide
anion
(O2•-
)
via
Type-I
pathway
under
laser
irradiation.
Subsequently,
infections
effectively
eliminated
through
reactive
oxygen
species
(ROS)
gas
synergistic
therapy.
addition,
also
stimulates
collagen
deposition
promotes
angiogenesis
in
vivo.
Therefore,
efficiently
treat
biofilm-related
infections,
providing
an
alternative
approach
combat
ACS Applied Materials & Interfaces,
Год журнала:
2023,
Номер
15(15), С. 18720 - 18733
Опубликована: Апрель 5, 2023
Implant
infections
are
difficult
to
cure
by
traditional
antibiotic
therapy
due
bacterial
biofilm-induced
tolerance
and
impaired
immune
responses.
To
efficiently
treat
implant
infections,
therapeutic
agents
need
kill
bacteria
regulate
the
inflammatory
response
of
cells
during
biofilm
elimination
process.
Herein,
multifunctional
smart
hollow
Cu2MoS4
nanospheres
(H-CMS
NSs)
with
pH-responsive
enzyme-like
activities
were
prepared
for
self-adaptively
eliminating
biofilms
regulating
inflammation
macrophages
in
infections.
During
infection,
tissue
microenvironment
around
implants
is
acidic.
H-CMS
NSs
oxidase
(OXD)/peroxidase
(POD)-like
can
catalyze
reactive
oxidative
species
(ROS)
generation
directly
killing
polarizing
a
proinflammatory
phenotype.
Moreover,
POD-like
activity
antibacterial
property
be
further
enhanced
under
ultrasound
(US)
irradiation.
After
biofilms,
shifts
from
acidic
neutral.
show
catalase
(CAT)-like
eliminate
excessive
ROS,
which
polarizes
anti-inflammatory
phenotype
promotes
healing
infected
tissue.
This
work
provides
nanozyme
self-adaptive
regulation
antibiofilm
ROS
generation/elimination
according
different
pathological
microenvironments
stages.