Journal of Material Science and Technology, Год журнала: 2024, Номер 205, С. 98 - 108
Опубликована: Апрель 22, 2024
Язык: Английский
Journal of Material Science and Technology, Год журнала: 2024, Номер 205, С. 98 - 108
Опубликована: Апрель 22, 2024
Язык: Английский
Chemical Engineering Journal, Год журнала: 2022, Номер 453, С. 139839 - 139839
Опубликована: Окт. 19, 2022
Treatment of bacterial biofilms remains a great challenge in the clinic. Recently, ultrasound (US)-driven antimicrobial sonodynamic therapy (aSDT) has been considered as an emerging therapeutic strategy for treatment biofilm infections. However, hypoxic microenvironment and restricted diffusion sonosensitizers within substantially reduce efficacy aSDT. Herein, microenvironment-responsive nanoplatform was proposed to promote degradation sonosensitizer penetration, relieve microenvironment, thereby augmenting aSDT efficiency against This prepared by modifying manganese dioxide nanosheets (MNS) with α-amylase, polyethylene glycol (PEG), chlorin e6 (Ce6) form MNS-α-amylase/PEG-Ce6 (MAPC). After delivery into biofilm-infected tissues, MAPC decompose acidic locally release α-amylase Ce6. The degrades extracellular polymeric substances Ce6 penetration. In addition, MNS catalyze conversion endogenously overproduced H2O2 O2 infected tissue further enhance antibiofilm Such hypoxia-relief enhanced show approximately 6.9 log units (99.99998%) reduction bacteria vitro, efficiently treat methicillin-resistant Staphylococcus aureus (MRSA) biofilms-infected mice. Overall, improves penetration relieves effects MAPC. Thus, use this provides promising combating biofilm-associated
Язык: Английский
Процитировано
58Journal of Materials Chemistry B, Год журнала: 2023, Номер 11(29), С. 6746 - 6761
Опубликована: Янв. 1, 2023
The slow healing of diabetic wounds has seriously affected human health. Meanwhile, the open are susceptible to bacterial infection. Clinical therapeutic methods such as antibiotic therapy, insulin treatment, and surgical debridement have made great achievements in treatment wounds. However, drug-resistant bacteria will develop after long-term use antibiotics, resulting decreased efficacy. To improve effect, increasing drug concentration is a common strategy clinical practice, but it also brings serious side effects. In addition, hyperglycemia control or can easily bring negative effects patients, hypoglycemia damage normal tissue. Therefore, essential novel strategies effectively promote wound healing. recent years, nanozyme-based systems received extensive attention because they possess advantages nanomaterials natural enzymes. For example, nanozymes small size high surface area volume ratio, which enhance tissue penetration increase reactive active sites. Moreover, compared with enzymes, more stable catalytic activity, lower production cost, stronger operability. this review, we first reviewed basic characteristics then elaborated on mechanism action principle different types from three aspects: controlling infection, hyperglycemia, relieving inflammation. Finally, challenges, prospects future implementation for outlined.
Язык: Английский
Процитировано
44Advanced Healthcare Materials, Год журнала: 2023, Номер 12(26)
Опубликована: Май 15, 2023
Abstract The application of medical implants has greatly improved the survival rate and life quality patients. Nevertheless, in recent years, there are increasing cases implant dysfunction or failure because bacterial infections. Despite significant improvements biomedicine, still serious challenges treatment implant‐related With formation biofilms development resistance, these limitations lead to a low efficacy conventional antibiotics. To address challenges, it is urgent exploit innovative strategies for Based on ideas, environment‐responsive therapeutic platforms with high selectivity, drug minor dose‐limiting toxicity have attracted widespread attention. By using exogenous/endogenous stimuli, antibacterial activity therapeutics can be activated demand exhibit remarkable effects. Exogenous stimuli include photo, magnetism, microwave, ultrasound. Endogenous mainly pathological characteristics infections such as acidic pH, anomalous temperature, abnormal enzymatic activities. In this review, progress spatiotemporally controlled release/activation systematically summarized. Afterward, opportunities emerging highlighted. Finally, hoped that review will offer novel ideas techniques combat
Язык: Английский
Процитировано
43ACS Nano, Год журнала: 2023, Номер 17(11), С. 10019 - 10032
Опубликована: Май 26, 2023
Inhibition of quorum sensing (QS) is considered as an effective strategy in combatting biofilm-associated bacterial infections. However, the application inhibitors (QSI) strongly restricted by poor water-solubility and low bioavailability. We herein fabricate pH-sensitive curcumin (Cur) loaded clustered nanoparticles with active targeting ability (denoted anti-CD54@Cur-DA NPs) to inhibit QS for enhanced antibiotic therapy. Cur-DA NPs are first prepared through electrostatic interaction between Cur amino-ended poly(amidoamine) dendrimer (PAMAM) 2,3-dimethyl maleic anhydride (DA) modified biotin-poly(ethylene glycol)-polylysine (biotin-PEG-PLys). Anti-CD54@Cur-DA then obtained modification anti-CD54. PAMAM can be released from acidic pH, leading simultaneous charge reversal size decrease, which beneficial biofilm penetration. hence much better inhibiting than free due Compared Cur, exhibit stronger capability development architecture maturation, thus downregulating efflux pump-related genes improving bactericidal performance multiple antibiotics, including Penicillin G, ciprofloxacin, tobramycin. Moreover, since anti-CD54 selectively bind inflamed endothelial cells, targeted accumulated bacteria-infected tissues. The sequential treatment using antibiotics effectively reduce burden alleviate inflammation a chronic lung infection model vivo. This research provides way improve therapeutic QSI enhance anti-biofilm effects radiate vitality conventional treating
Язык: Английский
Процитировано
42Biomaterials Research, Год журнала: 2023, Номер 27(1)
Опубликована: Фев. 9, 2023
The advent of drug-resistant pathogens results in the occurrence stubborn bacterial infections that cannot be treated with traditional antibiotics. Antibacterial immunotherapy by reviving or activating body's immune system to eliminate pathogenic bacteria has confirmed promising therapeutic strategies controlling infections. Subsequent studies found antimicrobial its own benefits and limitations, such as avoiding recurrence infection autoimmunity-induced side effects. Current indicate various antibacterial inducing regulation can achieve superior efficacy compared monotherapy alone. Therefore, summarizing recent advances nanomedicine immunomodulatory functions for combating is necessary. Herein, we briefly introduce crisis caused opportunity immunotherapy. Then, immune-involved multimodal therapy treatment infectious diseases was systematically summarized. Finally, prospects challenges combinational are discussed.
Язык: Английский
Процитировано
34Materials & Design, Год журнала: 2023, Номер 229, С. 111927 - 111927
Опубликована: Апрель 8, 2023
The development of functional wound dressings capable both rapid hemostasis and high-efficiency antimicrobial is essential for the management severe bleeding wounds. Cotton are widely used in clinical practice; however, few can simultaneously achieve high-efficacy antimicrobial. Herein, a versatile cotton dressing (GCQCNF-5) was masterly developed by sequentially deposition catechol modified quaternary chitosan (CQCS) gelatin onto nonwoven fabric (NF) surface. Because presence sponge layer with suitable thickness porosity on its surface, GCQCNF-5 exhibits notably enhanced hemostatic effect compared to NF vitro vivo, which even slightly superior that MHS (a commercial sponge). Moreover, after exerting effect, further exploit CQCS exert excellent immediate long-lasting bacteriostatic effects. In vivo healing experiments indicated could significantly promote infected wounds effectively sterilizing, absorbing exudates, providing moist environments. This study clearly demonstrated hemostasis, antimicrobial, wounds, great application potential treatment
Язык: Английский
Процитировано
31Advanced Materials, Год журнала: 2023, Номер 35(52)
Опубликована: Ноя. 17, 2023
Stubborn biofilm infections pose serious threats to human health due the persistence, recurrence, and dramatically magnified antibiotic resistance. Photodynamic therapy has emerged as a promising approach combat biofilm. Nevertheless, how inhibit bacterial signal transduction system efflux pump conquer recurrence resistance remains challenging unaddressed issue. Herein, boric acid-functionalized lipophilic cationic type I photosensitizer, ACR-DMP, is developed, which efficiently generates •OH overcome hypoxic microenvironment photodynamically eradicates methicillin-resistant Staphylococcus aureus (MRSA) biofilms. Furthermore, it not only alters membrane potential homeostasis osmotic pressure balance its strong binding ability with plasma but also inhibits quorum sensing two-component system, reduces virulence factors, regulates activity of drug attributed glycan-targeting ability, helping prevent In vivo, ACR-DMP successfully obliterates MRSA biofilms attached implanted medical catheters, alleviates inflammation, promotes vascularization, thereby combating accelerating wound healing. This work provides an efficient strategy stubborn multidrug offers systematic guidance for rational design next-generation advanced antimicrobial materials.
Язык: Английский
Процитировано
31Advanced Healthcare Materials, Год журнала: 2023, Номер 12(29)
Опубликована: Июль 29, 2023
The presence of a biofilm matrix barrier and hypoxic microenvironment within the significantly impedes efficacy photodynamic therapy for bacterial infections. Herein, phototherapeutic nanoagent with type-I behavior nitric oxide (NO) release performance is reported overcoming biofilm-associated infectious diseases. Sodium nitroprusside (SNP), NO donor, loaded onto amino-modified mesoporous silica nanoparticles (MSN) to form MSN@SNP NPs. resulting are further modified porphyrin-based metal-organic framework (Ti-TCPP MOF) obtain MSN@MOF/SNP NPs (MMS NPs) applications. In hypoxia microenvironment, MMS enhance permeability induce generation hydroxyl radical (•OH) superoxide anion (O2•- ) via Type-I pathway under laser irradiation. Subsequently, infections effectively eliminated through reactive oxygen species (ROS) gas synergistic therapy. addition, also stimulates collagen deposition promotes angiogenesis in vivo. Therefore, efficiently treat biofilm-related infections, providing an alternative approach combat
Язык: Английский
Процитировано
30Heliyon, Год журнала: 2023, Номер 9(11), С. e22105 - e22105
Опубликована: Ноя. 1, 2023
With the wide spread of Multidrug-resistant bacteria (MDR) due to transfer and acquisition antibiotic resistance genes formation microbial biofilm, various researchers around world are looking for a solution overcome these resistances. One potential strategy best candidate infections is using an effective nanomaterial with antibacterial properties against them. analysis: In this study, we overview nanomaterials anti-MDR anti-biofilm properties. Hence, systematically explored biomedical databases (Web Sciences, Google Scholar, PubMed, Scopus) categorize related studies about activities from 2007 December 2022. total, forty-one were investigated find information during 2007-2022. According collected documents, nineteen types showed putative effects such as Cu, Ag, Au, Au/Pt, TiO2, Al2O3, ZnO, Se, CuO, Cu/Ni, Cu/Zn, Fe3O4, Au/Fe3O4, Au/Ag, Graphene O, CuS. addition, seven them considered agents Au/Ag. studies, each has been designed different methods their standard strains, clinical MDR bacterial biofilms have in-vitro in-vivo conditions. destructive mechanism on structures. Various nanoparticles (NP) introduced designing new drug medical equipment preventing infectious disease outbreaks by biofilm.
Язык: Английский
Процитировано
30Chemical Engineering Journal, Год журнала: 2023, Номер 479, С. 147645 - 147645
Опубликована: Ноя. 24, 2023
Язык: Английский
Процитировано
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