TrAC Trends in Analytical Chemistry, Год журнала: 2024, Номер 178, С. 117812 - 117812
Опубликована: Июнь 14, 2024
Язык: Английский
Biosensors and Bioelectronics, Год журнала: 2024, Номер 255, С. 116263 - 116263
Опубликована: Апрель 4, 2024
Язык: Английский
Процитировано
10
Nano Today, Год журнала: 2024, Номер 57, С. 102403 - 102403
Опубликована: Июль 16, 2024
Язык: Английский
Процитировано
10
Microchemical Journal, Год журнала: 2025, Номер unknown, С. 112795 - 112795
Опубликована: Янв. 1, 2025
Язык: Английский
Процитировано
1
ACS Applied Materials & Interfaces, Год журнала: 2025, Номер unknown
Опубликована: Янв. 30, 2025
The single-luminophore-based ratiometric electrochemiluminescence (ECL) sensor coupling bidirectional regulator has become a research hotspot in the detection field because of its simplicity and accuracy. However, limited hinders further development. In this study, by leveraging robust predictive capabilities machine learning, we prepared an Fe-based metal-organic framework (FeMOF) as for modulating dual-emission ECL signals single luminophore first time. proof concept was demonstrated applying FeMOF to classical Ru(bpy)32+, results showed ability enhance cathode signal (Ecathode) inhibit anode (Eanode). As example, Tau protein (Tau) utilizing FeMOF/Ru(bpy)32+ system developed. incorporation effectively mitigated erratic fluctuations or minor discrepancies between two stronger correlation stability Ecathode/Eanode than before regulation. result, good analytical performance with limit low 3.38 fg mL-1 (S/N = 3). Moreover, it not only comparable test commercially available ELISA kit but also could well distinguish normal Alzheimer's disease (AD) patients (80% specificity 90% sensitivity). Thus, proposed strategy is promising be extended other luminophores MOFs, providing new path sensors.
Язык: Английский
Процитировано
1
ACS Nano, Год журнала: 2023, Номер 17(21), С. 20776 - 20803
Опубликована: Окт. 24, 2023
External light sources, such as lasers, emitting diodes (LEDs) and lamps, are widely applied in photodynamic therapy (PDT); however, their use is severely limited by the nature of shallow tissue penetration depth. The recent exploration delivery or local generation on tumor sites has attracted much attention, owing to fact that these systems significantly endowed with high penetration. In this review, we briefly introduced principle "on-spot systems" PDT. These divided into different categories: (1) implantable luminescence, (2) mechanoluminescence, (3) electrochemiluminescence, (4) Cerenkov (5) chemiluminescence, (6) bioluminescence. Finally, applications, advantages, disadvantages PDT will be appropriately summarized further discussed detail. We believe review provide general guidance for design clinical studies PDT-mediated cancer treatments unparalleled merits.
Язык: Английский
Процитировано
20
Sensors, Год журнала: 2024, Номер 24(9), С. 2904 - 2904
Опубликована: Май 1, 2024
Demand is strong for sensitive, reliable, and cost-effective diagnostic tools cancer detection. Accordingly, bead-based biosensors have emerged in recent years as promising platforms based on wide-ranging biomarkers owing to the versatility, high sensitivity, flexibility perform multiplexing of beads. This comprehensive review highlights trends innovations development cancer-biomarker We introduce various types such optical, electrochemical, magnetic biosensors, along with their respective advantages limitations. Moreover, summarizes latest advancements, including fabrication techniques, signal-amplification strategies, integration microfluidics nanotechnology. Additionally, challenges future perspectives field detection are discussed. Understanding these can greatly contribute improvements diagnostics, thereby facilitating early personalized treatments.
Язык: Английский
Процитировано
8
Sensors and Actuators B Chemical, Год журнала: 2024, Номер 407, С. 135498 - 135498
Опубликована: Фев. 15, 2024
Язык: Английский
Процитировано
7
Microchimica Acta, Год журнала: 2024, Номер 191(6)
Опубликована: Май 31, 2024
Electrogenerated chemiluminescence (ECL) stands out as a remarkable phenomenon of light emission at electrodes initiated by electrogenerated species in solution. Characterized its exceptional sensitivity and minimal background optical signals, ECL finds applications across diverse domains, including biosensing, imaging, various analytical applications. This review aims to serve comprehensive guide the utilization Beginning with brief exposition on theory basis generation, we elucidate systems employed initiate ECL. Furthermore, delineate principal utilized for generation contexts, elucidating both advantages challenges inherent their use. Additionally, provide an overview different electrode materials novel ECL-based protocols tailored purposes, specific emphasis biosensing
Язык: Английский
Процитировано
7
Frontiers in Sensors, Год журнала: 2024, Номер 5
Опубликована: Май 30, 2024
Regardless of many years research work and conducting numerous clinical studies, breast cancer (BC) continues to grow among women, threatening their lives future. Currently, it affects more than 10% women globally. Therefore, researchers have recently redirected endeavors toward detecting BC at an early stage, recognizing its substantial impact on survival rates, acknowledging immense potential for providing effective treatments this diagnosed disease stage. The utilization biomarker-based diagnostic techniques significantly contributes the advancement detection precision. A wide range biomarkers is linked every newly case. Traditionally, was using a variety such as mammography, molecular imaging, ultrasonography. These had several drawbacks, drawing attention scientists developing new methods strategies. Among these strategies, electrochemical biosensors proven be excellent alternatives complex traditional strategies in terms performance, accuracy, robustness, tremendous applications. In review, use conventional well challenges shortcomings been stated. Moreover, deep discussion given developed nanocomposite-based bio-sensing approaches that exploited quantification biomarkers.
Язык: Английский
Процитировано
6
Biosensors, Год журнала: 2024, Номер 14(7), С. 326 - 326
Опубликована: Июнь 30, 2024
Mesoporous silica nanoparticles (MSNs) exhibit highly beneficial characteristics for devising efficient biosensors different analytes. Their unique properties, such as capabilities stable covalent binding to recognition groups (e.g., antibodies or aptamers) and sensing surfaces, open a plethora of opportunities biosensor construction. In addition, their structured porosity offers entrapping signaling molecules (dyes electroactive species), which could be released efficiently in response desired analyte effective optical electrochemical detection. This work an overview recent research studies (in the last five years) that contain MSNs platforms detection cancer biomarkers, classified by type. this study provides well methods general.
Язык: Английский
Процитировано
6