Endogenous/exogenous stimuli‐responsive smart hydrogels for diabetic wound healing
Aggregate,
Год журнала:
2024,
Номер
unknown
Опубликована: Ноя. 6, 2024
Abstract
Diabetes
significantly
impairs
the
body's
wound‐healing
capabilities,
leading
to
chronic,
infection‐prone
wounds.
These
wounds
are
characterized
by
hyperglycemia,
inflammation,
hypoxia,
variable
pH
levels,
increased
matrix
metalloproteinase
activity,
oxidative
stress,
and
bacterial
colonization.
complex
conditions
complicate
effective
wound
management,
prompting
development
of
advanced
diabetic
care
strategies
that
exploit
specific
characteristics
such
as
acidic
pH,
high
glucose
stress
trigger
controlled
drug
release,
thereby
enhancing
therapeutic
effects
dressings.
Among
solutions,
hydrogels
emerge
promising
due
their
stimuli‐responsive
nature,
making
them
highly
for
managing
these
The
latest
advancements
in
mono/multi‐stimuli‐responsive
smart
showcase
superiority
potential
healthcare
materials,
highlighted
relevant
case
studies.
However,
traditional
dressings
fall
short
meeting
nuanced
needs
wounds,
adjustable
adhesion,
easy
removal,
real‐time
status
monitoring,
dynamic
release
adjustment
according
wound's
conditions.
Responsive
represent
a
significant
leap
forward
proficient
sensing
responding
environment,
offering
more
targeted
approach
treatment.
This
review
highlights
recent
dressing,
delivery,
emphasizing
role
improving
healing.
It
addresses
ongoing
challenges
future
directions,
aiming
guide
clinical
adoption.
Язык: Английский
Engineered hydrogel platform for diabetic wound healing
Chemical Engineering Journal,
Год журнала:
2025,
Номер
unknown, С. 160379 - 160379
Опубликована: Фев. 1, 2025
Язык: Английский
Tunable Hierarchically Porous Gadolinium‐Based Metal‐Organic Frameworks for Bacteria‐Targeting Magnetic Resonance Imaging and In Situ Anti‐Bacterial Therapy
Advanced Science,
Год журнала:
2025,
Номер
unknown
Опубликована: Фев. 20, 2025
Abstract
Currently,
there
are
no
non‐invasive
tools
to
accurately
diagnose
deep
surgical
site
bacterial
infections
before
they
cause
significant
anatomical
damage
in
the
clinic.
An
urgent
need
exists
for
bacteria‐targeting
bifunctional
probes
detection
of
and
precise
situ
treatment.
Herein,
1‐borono‐3,5‐benzenedicarboxylic
acid
(BBDC)
ligand
paramagnetic
Gd
3
+
into
one
single
metal‐organic
frameworks
(MOFs)
integrated,
synergistically
realizing
bacteria‐specific
magnetic
resonance
imaging
(MRI)
diagnosis
MRI‐guided
antibacterial
Molecular
simulations
nitrogen
adsorption‐desorption
experiments
demonstrate
that
a
hierarchical
porous
structure
can
be
constructed
by
tuning
/BBDC
ratio,
which
endows
Gd‐BBDC1.25
MOFs
with
an
impressive
longitudinal
proton
relaxivity
15.81
mM
−1
s
.
In
particular,
boronic
group
BBDC
remained
intact
during
MOF
synthesis,
ensuring
have
unique
combination
high
sensitivity
specificity
bacteria.
Through
reduction
reaction,
silver
nanoparticles
（Ag
NPs）‐modified
form
Ag@Gd‐BBDC1.25,
interfacial
Schottky
heterojunction
nanozyme,
enhances
their
peroxidase
(POD)‐catalyze
activity.
Furthermore,
it
is
demonstrated
Ag@Gd‐BBDC1.25
probe
image
as
few
10
5
colony‐forming
units
(cfu)
vivo
effectively
eradicate
bacteria
situ.
Язык: Английский
A Metal-Based Heterojunction with Releasable Multiple Cations and Reactive Oxygen for Eradication of Multidrug-Resistant Bacteria
Опубликована: Янв. 1, 2025
Spherical
heterojunction
nanocomposite
materials
are
utilized
to
treat
wound
infections
caused
by
drug-resistant
bacteria
synergistically
generating
reactive
oxygen
species
(ROS)
and
multiple
cations
(multiple
inorganic
or
organic
ions
with
positive
points).
However,
there
is
an
ongoing
debate
on
the
relative
contributions
of
ROS
towards
antibacterial
activity.
With
aim
investigating
activity,
this
study
synthesized
CuFe2O4/Cu@PEI/Ag
(ZPA)
nanocomposites
release
abundant
•O2-,
•OH,
Fe3+,
Cu2+,
Ag+,
polyethyleneimine
(PEI).
The
results
revealed
that
after
25
min,
at
a
concentration
40.8
μg/mL,
material
exhibited
inhibition
rate
over
99.99%
against
Staphylococcus
aureus
(S.
aureus)
methicillin-resistant
S.
(T-
aureus).
This
activity
could
be
attributed
(Fe3+,
Ag+
PEI)
in
following
order:
>
•O2-
•OH
single
cation.
potential
mechanism
involved
synergy
mechanisms:
Leakage
cytoplasmic
content
due
damage
bacterial
cell
wall
alteration
secondary
structure
bound
via
electrostatic
attraction.
By
healing
T
-
aureus-induced
infection
completely
eliminating
burden
11
days
ZPA
also
effectively
polarized
M1
type
macrophages
M2
vivo.
Thus,
findings
elucidate
combined
effect
free
radicals
properties
composite
materials.
indicate
holds
clinical
for
treating
infections.
Язык: Английский
Enabling Targeted Drug Delivery for Treatment of Ulcerative Colitis with Mucosal‐Adhesive Photoreactive Hydrogel
Advanced Science,
Год журнала:
2025,
Номер
unknown
Опубликована: Фев. 3, 2025
Abstract
Ulcerative
colitis
(UC)
is
a
chronic
inflammatory
bowel
disease.
UC
treatments
are
limited
by
significant
adverse
effects
associated
with
non‐specific
drug
delivery,
such
as
systematic
inhibition
of
the
host
immune
system.
Endoscopic
delivery
synthetic
hydrogel
material
biocompatible
gelation
that
can
efficiently
cover
irregular
tissue
surfaces
provides
an
effective
approach
for
targeted
at
gastrointestinal
(GI)
tract.
An
ideal
integration
intestinal
epithelium
entails
integrated
and
preferable
chemically
bonded
interface
between
mucosal
surface.
In
this
study,
photo‐triggered
coupling
reaction
leveraged
crosslinking
platform
to
develop
mucosal‐adhesive
hydrogel,
which
compatible
endoscope‐directed
treatment.
The
results
demonstrated
superior
spatiotemporal
specificity
pharmacokinetics
system
in
vivo.
Delivery
different
drugs
leads
greatly
enhanced
therapeutic
efficacy
significantly
reduced
systemic
exposure
rat
models.
study
presents
strategy
persistent
Язык: Английский
Heterojunction nanocatalytic medicine
Chinese Science Bulletin (Chinese Version),
Год журнала:
2025,
Номер
unknown
Опубликована: Янв. 1, 2025
Язык: Английский
Engineered porous bio-ceramic coating with antibacterial and excellent biocompatibility on the surface of low modulus multi-component titanium alloy
Surface and Coatings Technology,
Год журнала:
2025,
Номер
unknown, С. 132121 - 132121
Опубликована: Апрель 1, 2025
Язык: Английский
Pluripotent polysaccharide coordinated hydrogels remodel inflammation, neovascularization and reepithelization for efficient diabetic wound prohealing
Journal of Controlled Release,
Год журнала:
2024,
Номер
377, С. 37 - 53
Опубликована: Ноя. 17, 2024
Язык: Английский
Light-Based 3D Bioprinting Techniques for Illuminating the Advances of Vascular Tissue Engineering
Materials Today Bio,
Год журнала:
2024,
Номер
29, С. 101286 - 101286
Опубликована: Окт. 2, 2024
Vascular
tissue
engineering
faces
significant
challenges
in
creating
Язык: Английский