Microneedles as Transdermal Drug Delivery System for Enhancing Skin Disease Treatment

Acta Pharmaceutica Sinica B, Год журнала: 2024, Номер 14(12), С. 5161 - 5180

Опубликована: Авг. 23, 2024

Microneedles (MNs) serve as a revolutionary paradigm in transdermal drug delivery, heralding viable resolution to the formidable barriers presented by cutaneous interface. This review examines MNs an advanced approach enhancing dermatological pathology management. It explores complex dermis structure and highlights limitations of traditional methods, emphasizing MNs' advantage bypassing stratum corneum deliver drugs directly subdermal matrix. The discourse outlines diverse typologies MNs, including solid, coated, hollow, hydrogel, dissolvable versions. Each type is characterized its unique applications benefits. treatise details deployment alleviation cancers, administration inflammatory dermatoses such psoriasis atopic dermatitis, their utility wound Additionally, paper contemplates prospects within realm aesthetic dermatology burgeoning market traction cosmetic MN formulations. summarizes scientific commercial challenges clinical adoption therapeutics, dosage calibration, pharmacodynamics, biocompatibility, patient compliance, sterilization, mass production, regulatory oversight. emphasizes need for ongoing research, innovation, harmonization overcome these obstacles fully realize potential treating skin diseases improving welfare. presents comprehensive overview recent accomplishments, remaining challenges, future microneedle-facilitated therapy afflictions.

Язык: Английский

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Intranasal liposomes co-delivery of Aβ-targeted KLVFF and ROS-responsive ceria for synergistic therapy of Alzheimer’s disease

Chemical Engineering Journal, Год журнала: 2024, Номер 494, С. 153210 - 153210

Опубликована: Июнь 16, 2024

β-Amyloid (Aβ) aggregation and oxidative stress are primary pathological features of Alzheimer's disease (AD). Combination therapies that target brain tissue corporately address these main factors required for effective AD treatment. Here, we developed a multifunctional liposome delivery system (KLVFF@LIP-CeO2) co-delivery Aβ-targeted KLVFF reactive oxygen species (ROS)-responsive Ceria (CeO2) through intranasal administration. After Aβ1-42-induced ROS apoptosis in HT22 cells, KLVFF@LIP-CeO2 exhibited significant protective effects by inhibiting Aβ scavenging multi-ROS. With features, verified the therapeutic effectiveness APPswe/PSEN1dE9 (APP/PS1) model mice. administration, demonstrated sufficient rapid accumulation significantly alleviated deposition stress, contributing to rescue cognitive impairment APP/PS1 These results highlight clinical potential multi-targeted nanoparticles synergistic therapy AD.

Язык: Английский

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Smart Microneedles in Biomedical Engineering: Harnessing Stimuli‐Responsive Polymers for Novel Applications

Polymers for Advanced Technologies, Год журнала: 2024, Номер 35(12)

Опубликована: Дек. 1, 2024

ABSTRACT This review aims to provide a comprehensive analysis of recent advancements in smart microneedles (MNs) within the biomedical field, focusing on integration stimuli‐responsive polymers for enhanced therapeutic and diagnostic applications. Conventional drug delivery methods are known face limitations precision, safety, patient compliance, which can be addressed by innovative features MNs. Through use various polymers, these MNs have been designed react environmental or physiological cues, allowing on‐demand release, biomarker sensing, localized interventions. Fundamental materials used fabrication MNs, including metals, composite hydrogels, reviewed, different categories stimuli‐responsiveness, such as photo, electro, thermal, mechanical, biochemical, explored. Application‐specific designs areas delivery, cancer therapy, diabetes management, skin disease treatments also examined. this discussion, it is highlighted that poised play significant role advancing personalized noninvasive medical treatments.

Язык: Английский

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Biomimetic polydopamine loaded with janus kinase inhibitor for synergistic vitiligo therapy via hydrogel microneedles

Journal of Nanobiotechnology, Год журнала: 2025, Номер 23(1)

Опубликована: Янв. 30, 2025

Язык: Английский

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Biocompatible and Size-Dependent Melanin-Like Nanocapsules for Efficient Therapy in Hyperoxia-Induced Acute Lung Injury

Biomaterials, Год журнала: 2025, Номер 318, С. 123169 - 123169

Опубликована: Фев. 5, 2025

Язык: Английский

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Microsphere-integrated hydrogel microneedle patch for sustained methotrexate delivery in the long-term management of atopic dermatitis

European Polymer Journal, Год журнала: 2025, Номер unknown, С. 113877 - 113877

Опубликована: Фев. 1, 2025

Язык: Английский

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Galvanic Cell Bipolar Microneedle Patches for Reversing Photoaging Wrinkles

Advanced Materials, Год журнала: 2025, Номер unknown

Опубликована: Март 11, 2025

Abstract Excessive exposure to ultraviolet (UV) radiation is a major factor in the development of skin photoaging wrinkles. While current treatments can slow progression photoaging, it very difficult achieve complete reversal. This study introduces galvanic cell microneedle (GCMN) patches with magnesium‐containing bipolar electrodes. These operate through mechanism, generating microcurrents and releasing hydrogen gas magnesium ions via redox reaction. The combination hydrogen's antioxidant anti‐inflammatory properties, microcurrent‐induced stimulation migration, magnesium's promotion angiogenesis macrophage M2 polarization synergistically works reverse wrinkles rejuvenate skin. Furthermore, this work examines how GCMNs may influence transforming growth factor‐β/Smad (TGF‐β/Smad) pathway. approach shows promise for advancing research field medical cosmetology.

Язык: Английский

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Self‐Adaptive Dynamic Hydrogel Disrupts Ironclad Defense to Augment Photothermal‐Catalytic Therapy Against Melanoma Recurrence and Promote Post‐Surgical Wound Healing

Advanced Functional Materials, Год журнала: 2025, Номер unknown

Опубликована: Март 20, 2025

Abstract Post‐surgical photothermal therapy for melanoma faces significant challenges including resistance, tumor recurrence, and wound healing. In response, a self‐adaptive hydrogel (VPHCh) is designed, synthesized from carboxymethyl chitosan, integrated with vanadium‐polydopamine (V‐PDA) nanoplatform, which significantly enhances both catalytic properties. The advanced effectively inhibits recurrence facilitates healing through the precise modulation of V‐PDA release dynamics. infection microenvironment, rapidly released, delivering outstanding effects. Furthermore, synergistic actions reactions, induces endoplasmic reticulum stress, disrupting Wnt/β‐catenin signaling pathway enhancing V 5+ ‐mediated glutathione depletion, thereby increasing cell sensitivity to ferroptosis. Importantly, lipid peroxidation during ferroptosis further degradation heat shock protein 90, markedly augmenting effects therapies. Additionally, within VPHCh enables controlled sustained V‐PDA, promoting proliferation, angiogenesis, M2 macrophage polarization, accelerating also exhibits remarkable antibacterial properties, inhibiting bacterial facilitating Consequently, this dynamically adaptive represents promising adjuvant in post‐surgical treatment, offering substantial potential inhibit accelerate

Язык: Английский

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Hyperthermia-enhanced immunoregulation hydrogel for oxygenation and ROS neutralization in diabetic foot ulcers

Опубликована: Март 1, 2025

Язык: Английский

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Assembly of a MnO₂ Nanosheets-Based Hydrogel for Regulating Oxidative Stress and Treating Atopic Dermatitis

ACS Applied Nano Materials, Год журнала: 2024, Номер 7(17), С. 21191 - 21199

Опубликована: Авг. 22, 2024

Manganese dioxide (MnO2) nanosheets with a well-defined 2D structure can serve as catalase (CAT) and superoxide dismutase (SOD) mimics hold high potential in regulating the oxidative stress of atopic dermatitis (AD). However, facile, time-saving, scalable synthesis high-activity MnO2 is still challenging. Here, we report one-step strategy explore its CAT SOD to exert antioxidant functions. After further gelatinization by integrating into poly(ethylene glycol)diacrylate (PEGDA) polymer (PGM hydrogel), obtained PGM hydrogel, characterized well-designed cross-linking density moisture retention, retains antioxidation cytoprotection ability. In AD-bearing mouse models, hydrogel facilitates recovery impaired mice skin, reducing severity score, scratching numbers, epidermal thickness, immune factors, including mast cells, IgE antibodies, inflammatory cytokines IL-4 IL-10. Such simple reliable approach paves way for scale practical application antioxidative immunoregulation agents AD therapy.

Язык: Английский

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