International Journal of Molecular Sciences,
Год журнала:
2022,
Номер
23(24), С. 16093 - 16093
Опубликована: Дек. 17, 2022
Remyelination
therapies,
which
are
currently
under
development,
have
a
great
potential
to
delay,
prevent
or
even
reverse
disability
in
multiple
sclerosis
patients.
Several
models
available
study
the
effectiveness
of
novel
compounds
vivo,
among
is
cuprizone
model.
This
model
characterized
by
toxin-induced
demyelination,
followed
endogenous
remyelination
after
cessation
intoxication.
Due
its
high
reproducibility
and
ease
use,
this
enjoys
popularity
various
research
industrial
groups.
In
review
article,
we
will
summarize
recent
findings
using
discuss
some
identified
promote
Neural Regeneration Research,
Год журнала:
2024,
Номер
20(1), С. 29 - 40
Опубликована: Апрель 3, 2024
The
development
of
neurodegenerative
diseases
is
closely
related
to
the
disruption
central
nervous
system
homeostasis.
Microglia,
as
innate
immune
cells,
play
important
roles
in
maintenance
homeostasis,
injury
response,
and
diseases.
Lactate
has
been
considered
a
metabolic
waste
product,
but
recent
studies
are
revealing
ever
more
physiological
functions
lactate.
Lactylation
an
pathway
lactate
function
involved
glycolysis-related
functions,
macrophage
polarization,
neuromodulation,
angiogenesis
also
implicated
various
This
review
provides
overview
homeostatic
regulatory
processes
microglia
lactylation,
histone
versus
non-histone
therapeutic
approaches
targeting
Finally,
we
summarize
current
research
on
lactylation
A
deeper
understanding
mechanisms
will
provide
options
for
treatment
Chronic
pain
is
commonly
linked
with
diminished
working
memory.
This
study
explores
the
impact
of
anesthetic
(S)-ketamine
on
spatial
memory
in
a
chronic
constriction
injury
(CCI)
mouse
model,
focusing
gut
microbiome.
We
found
that
multiple
doses
(S)-ketamine,
unlike
single
dose,
counteracted
reduced
spontaneous
alteration
percentage
(%SA)
Y-maze
test,
without
affecting
mechanical
or
thermal
sensitivity.
Additionally,
repeated
treatments
improved
abnormal
composition
microbiome
(β-diversity),
as
indicated
by
fecal
16S
rRNA
analysis,
and
increased
levels
butyrate,
key
–
brain
axis
mediator.
Protein
analysis
showed
these
also
corrected
upregulated
histone
deacetylase
2
(HDAC2)
downregulated
brain-derived
neurotrophic
factor
(BDNF)
hippocampi
CCI
mice.
Remarkably,
microbiota
transplantation
from
mice
treated
repeatedly
to
restored
%SA
hippocampal
BDNF
Butyrate
supplementation
alone
%SA,
BDNF,
HDAC2
Furthermore,
TrkB
receptor
antagonist
ANA-12
negated
beneficial
effects
impairment
These
results
indicate
administration
ameliorates
mice,
mediated
axis,
primarily
through
enhancement
signaling
butyrate.
Neurobiology of Disease,
Год журнала:
2022,
Номер
176, С. 105951 - 105951
Опубликована: Дек. 6, 2022
Multiple
sclerosis
(MS)
is
the
most
common
demyelinating
disease
that
attacks
central
nervous
system.
Dietary
intake
of
cuprizone
(CPZ)
produces
demyelination
resembling
patients
with
MS.
Given
role
vagus
nerve
in
gut-microbiota-brain
axis
development
MS,
we
performed
this
study
to
investigate
whether
subdiaphragmatic
vagotomy
(SDV)
affects
CPZ-treated
mice.
SDV
significantly
ameliorated
and
microglial
activation
brain
compared
sham-operated
Furthermore,
16S
ribosomal
RNA
analysis
revealed
improved
abnormal
gut
microbiota
composition
An
untargeted
metabolomic
demonstrated
blood
levels
metabolites
mice
Notably,
there
were
correlations
between
or
relative
abundance
several
microbiome
populations,
suggesting
a
link
brain.
There
also
metabolites.
Together,
these
data
suggest
CPZ
through
via
nerve.
Frontiers in Pharmacology,
Год журнала:
2024,
Номер
15
Опубликована: Апрель 11, 2024
(
R
,
S
)-
and
)-ketamine
have
made
significant
progress
in
the
treatment
of
treatment-resistant
depression
(TRD)
become
a
research
focus
recent
years.
However,
they
both
risks
psychomimetic
effects,
dissociative
abuse
liability,
which
limit
their
clinical
use.
Recent
preclinical
studies
shown
that
has
more
efficient
lasting
antidepressant
effect
with
fewer
side
effects
compared
to
)-ketamine.
small-sample
randomized
controlled
trial
found
although
lower
incidence
adverse
reactions
adult
TRD
treatment,
its
efficacy
is
not
superior
placebo
group,
indicating
advantage
still
needs
further
verification
clarification.
Moreover,
an
increasing
body
suggests
might
also
applications
prevention
medical
fields
or
diseases
such
as
cognitive
disorders,
perioperative
anesthesia,
ischemic
stroke,
Parkinson’s
disease,
multiple
sclerosis,
osteoporosis,
substance
use
inflammatory
diseases,
COVID-19,
organophosphate
poisoning.
This
article
briefly
reviews
mechanism
action
on
antidepressants
related
)-ketamine,
fully
revealing
application
potential
development
prospects,
providing
some
references
assistance
for
subsequent
expanded
research.
Journal of Affective Disorders,
Год журнала:
2024,
Номер
367, С. 745 - 755
Опубликована: Сен. 3, 2024
Chronic
restrain
stress
(CRS)
induces
depression-like
behaviors
and
demyelination
in
the
brain;
however,
relationship
between
these
remains
unclear.
Arketamine,
(R)-enantiomer
of
ketamine,
has
shown
rapid
antidepressant-like
effects
CRS-exposed
mice.
We
examined
whether
arketamine
can
improve
both
brains
Additionally,
we
investigated
role
transforming
growth
factor
β1
(TGF-β1)
beneficial
arketamine.
A
single
dose
(10
mg/kg)
improved
behavior
corpus
callosum
Correlations
were
found
this
region.
Furthermore,
pretreatment
with
RepSox,
an
inhibitor
TGF-β1
receptor,
significantly
blocked
on
Finally,
a
intranasal
administration
ameliorated
The
precise
mechanisms
by
which
contributes
to
remain
These
data
suggest
that
CRS-induced
may
contribute
behaviors,
mitigate
changes
through
TGF-β1-dependent
mechanism.
European Journal of Pharmacology,
Год журнала:
2024,
Номер
985, С. 177096 - 177096
Опубликована: Ноя. 3, 2024
The
novel
antidepressant
arketamine,
the
(R)-enantiomer
of
ketamine,
has
been
shown
to
ameliorate
demyelination
and
facilitate
remyelination
in
brains
cuprizone
(CPZ)-treated
mice.
However,
mechanisms
behind
its
effects
remain
unclear.
Given
role
transforming
growth
factor
β1
(TGF-β1)
arketamine's
antidepressant-like
effects,
we
examined
whether
TGF-β1
also
plays
a
on
CPZ-treated
Additionally,
investigated
intranasal
these
Repeated
intermittent
administration
arketamine
(10
mg/kg/day,
twice
weekly
for
last
2-weeks)
attenuated
corpus
callosum
(CC)
CPZ
(6
weeks)-treated
Furthermore,
pretreatment
with
RepSox
mg/kg/day),
an
inhibitor
TGF-β
receptor
1,
significantly
blocked
beneficial
CC
repeated
(3.0
μg/kg/day,
2
weeks)
ameliorated
facilitated
These
data
suggest
that
can
mitigate
facilitates
mice
through
TGF-β1-dependent
mechanism.
Brain Behavior & Immunity - Health,
Год журнала:
2022,
Номер
27, С. 100573 - 100573
Опубликована: Дек. 17, 2022
The
spleen
is
a
key
immune-related
organ
that
plays
role
in
communication
between
the
brain
and
immune
system
through
brain-spleen
axis
brain-gut-microbiota
axis.
However,
how
gut
microbiota
affects
function
remains
unclear.
Here,
we
investigated
whether
microbiome
depletion
induced
by
administration
of
an
antibiotic
cocktail
(ABX)
function.
Treatment
with
ABX
for
14
days
resulted
significant
decrease
weight
alterations
splenic
functions,
including
percentage
neutrophils,
NK
cells,
macrophages,
CD8+
T
cells.
Furthermore,
treatment
large
portion
microbiota.
Untargeted
metabolomics
analysis
showed
caused
levels
certain
compounds
plasma,
spleen,
brain.
Moreover,
decreased
expression
microglia
marker
Iba1
cerebral
cortex.
Interestingly,
correlations
were
found
abundance
different
components
metabolites
various
tissues,
as
well
cell
populations
weight.
These
findings
suggest
ABX-induced
altered
metabolite
may
affect
gut-microbiota-spleen-brain
