Neurochemistry International, Год журнала: 2025, Номер 185, С. 105961 - 105961
Опубликована: Март 5, 2025
Язык: Английский
Molecular Psychiatry, Год журнала: 2023, Номер 28(9), С. 3625 - 3637
Опубликована: Сен. 1, 2023
Abstract The human body harbors a diverse ecosystem of microorganisms, including bacteria, viruses, and fungi, collectively known as the microbiota. Current research is increasingly focusing on potential association between microbiota various neuropsychiatric disorders. resides in parts body, such oral cavity, nasal passages, lungs, gut, skin, bladder, vagina. gut gastrointestinal tract has received particular attention due to its high abundance role psychiatric neurodegenerative However, presents other tissues, though less abundant, also plays crucial immune system homeostasis, thus influencing development progression For example, imbalance associated periodontitis might increase risk for Additionally, studies using postmortem brain samples have detected widespread presence bacteria brains patients with Alzheimer’s disease. This article provides an overview emerging host disorders discusses future directions, underlying biological mechanisms, reliable biomarkers microbiota, microbiota-targeted interventions, this field.
Язык: Английский
Процитировано
50
Frontiers in Cellular and Infection Microbiology, Год журнала: 2023, Номер 13
Опубликована: Фев. 24, 2023
Polycystic ovary syndrome (PCOS) is the most common endocrine diseases in women of childbearing age that leads to menstrual disorders and infertility. The pathogenesis PCOS complex has not yet been fully clarified. Gut microbiota associated with lipid, glucose, steroid hormone metabolish. A large body studies demonstrated gut could regulate synthesis secretion insulin, affect androgen metabolism follicle development, providing us a novel idea for unravelling PCOS. relationship between particularly important. This study reviewed recent research advances roles occurrence development It expected provide new direction treatment based on microbiota.
Язык: Английский
Процитировано
42
Cancer Letters, Год журнала: 2025, Номер unknown, С. 217539 - 217539
Опубликована: Фев. 1, 2025
Язык: Английский
Процитировано
2
Molecular Psychiatry, Год журнала: 2023, Номер 28(12), С. 4968 - 4976
Опубликована: Июль 4, 2023
The coronavirus disease 2019 (COVID-19) pandemic caused by severe acute respiratory syndrome 2 (SARS-CoV-2) infection has resulted in a serious public health burden worldwide. In addition to respiratory, heart, and gastrointestinal symptoms, patients infected with SARS-CoV-2 experience number of persistent neurological psychiatric known as long COVID or "brain fog". Studies autopsy samples from who died COVID-19 detected the brain. Furthermore, increasing evidence shows that Epstein-Barr virus (EBV) reactivation after might play role symptoms. Moreover, alterations microbiome contribute this article, author reviews detrimental effects on brain, biological mechanisms (e.g., EBV reactivation, changes gut, nasal, oral, lung microbiomes) underlying COVID. addition, discusses potential therapeutic approaches based gut-brain axis, including plant-based diet, probiotics prebiotics, fecal microbiota transplantation, vagus nerve stimulation, sigma-1 receptor agonist fluvoxamine.
Язык: Английский
Процитировано
35
Progress in brain research, Год журнала: 2023, Номер unknown, С. 61 - 77
Опубликована: Янв. 1, 2023
Язык: Английский
Процитировано
31
Neurobiology of Disease, Год журнала: 2024, Номер 191, С. 106396 - 106396
Опубликована: Янв. 2, 2024
Studies from rodents to primates and humans indicate that individuals vary in how resilient they are stress, understanding the basis of these variations may help improve treatments for depression. Here we explored potential contribution gut microbiome such variation. Mice were exposed chronic unpredictable mild stress (CUMS) 4 weeks then allowed recover 3 weeks, after which subjected behavioral tests categorized as showing low or high resilience. The two types mouse compared terms hippocampal gene expression using RNA sequencing, fecal microbiomes 16S extent neurogenesis hippocampus immunostaining brain sections. Fecal microbiota transplanted either type into previously stress-exposed stress-naïve animals, effects transplantation on stress-induced behaviors examined. Finally, blocked temozolomide explore role promoted by enhancing resilience stress. Results showed highly stress-resilient mice, but not those with resilience, improved significantly measures anhedonia, despair, anxiety 3-week recovery CUMS. Their feces greater abundance Lactobacillus, Bifidobacterium Romboutsia than mice well lower Staphylococcus, Psychrobacter Corynebacterium. Similarly, animals Transplanting CUMS-exposed recipients rescued hippocampus, facilitating depression cognitive decline. Blockade abolished CUMS-induced decline In conclusion, our results suggested remodeling reverse impairment thereby promote
Язык: Английский
Процитировано
12
Frontiers in Aging Neuroscience, Год журнала: 2024, Номер 16
Опубликована: Фев. 27, 2024
Transcutaneous vagus nerve stimulation (tVNS) is an emerging non-invasive technique designed to stimulate branches of the distributed over body surface. Studies suggest a correlation between brain-gut-microbiota (BGM) axis and pathogenesis Alzheimer’s disease (AD). The BGM represents complex bidirectional communication system, with being crucial component. Therefore, electrical might have potential modify—most time probably in non-physiological way—the signal transmission within axis, potentially influencing progression or symptoms AD. This review explores interaction percutaneous emphasizing its effects on It examines various aspects, such as specific brain regions, gut microbiota composition, maintenance intestinal environmental homeostasis, inflammatory responses, plasticity, hypothalamic–pituitary–adrenal (HPA) regulation. suggests that tVNS could serve effective strategy modulate intervene treatment future.
Язык: Английский
Процитировано
12
Brain Behavior & Immunity - Health, Год журнала: 2024, Номер 36, С. 100729 - 100729
Опубликована: Янв. 23, 2024
Communication among the brain, gut and microbiota in is known to affect susceptibility stress, but mechanisms involved are unclear. Here we demonstrated that stress resistance mice was associated with more abundant
Язык: Английский
Процитировано
11
Neurobiology of Disease, Год журнала: 2024, Номер 192, С. 106433 - 106433
Опубликована: Фев. 7, 2024
Depression frequently occurs in patients with liver cirrhosis, yet the reasons for this correlation are not fully understood. Dysbiosis of gut microbiota has been implicated depression through gut–brain axis via vagus nerve. This study explored potential role gut–liver–brain nerve depression-like phenotypes mice cirrhosis. These underwent common bile duct ligation (CBDL), a method used to stimulate To assess behaviors, behavioral tests were conducted 10 days following either sham or CBDL surgeries. The displayed symptoms such as splenomegaly, elevated plasma levels interleukin-6 and tumor necrosis factor-α, decreased synaptic proteins prefrontal cortex (PFC), disrupted balance, changes blood metabolites (or lipids). Additionally, there positive negative correlations between relative abundance microbiome data Significantly, these reversed by performing subdiaphragmatic vagotomy. Intriguingly, improved after single injection arketamine, new antidepressant. results suggest that CBDL-induced mediated nerve, arketamine might offer treatment approach cirrhosis patients.
Язык: Английский
Процитировано
11
Brain Behavior and Immunity, Год журнала: 2024, Номер unknown
Опубликована: Ноя. 1, 2024
Язык: Английский
Процитировано
9