International Journal of Molecular Sciences,
Год журнала:
2022,
Номер
23(24), С. 16093 - 16093
Опубликована: Дек. 17, 2022
Remyelination
therapies,
which
are
currently
under
development,
have
a
great
potential
to
delay,
prevent
or
even
reverse
disability
in
multiple
sclerosis
patients.
Several
models
available
study
the
effectiveness
of
novel
compounds
vivo,
among
is
cuprizone
model.
This
model
characterized
by
toxin-induced
demyelination,
followed
endogenous
remyelination
after
cessation
intoxication.
Due
its
high
reproducibility
and
ease
use,
this
enjoys
popularity
various
research
industrial
groups.
In
review
article,
we
will
summarize
recent
findings
using
discuss
some
identified
promote
Metabolites,
Год журнала:
2022,
Номер
12(11), С. 1052 - 1052
Опубликована: Ноя. 1, 2022
Nerve
cell
death
accounts
for
various
neurodegenerative
disorders,
in
which
altered
immunity
to
the
integrated
central
nervous
system
(CNS)
might
have
destructive
consequences.
This
undesirable
immune
response
often
affects
progressive
diseases
such
as
Alzheimer's
disease,
Parkinson's
schizophrenia
and/or
amyotrophic
lateral
sclerosis
(ALS).
It
has
been
shown
that
commensal
gut
microbiota
could
influence
brain
several
machineries
of
function.
In
other
words,
disorders
may
be
connected
gut-brain-immune
correlational
system.
The
engrams
retain
information
a
certain
inflammation
body
involved
pathogenesis
disorders.
Tactics
involving
use
probiotics
fecal
transplantation
(FMT)
are
now
evolving
most
promising
valuable
modification
axis.
More
deliberation
this
concept
and
roles
would
lead
development
stupendous
treatments
prevention
of,
therapeutics
for,
intractable
including
International Journal of Molecular Sciences,
Год журнала:
2022,
Номер
23(24), С. 16093 - 16093
Опубликована: Дек. 17, 2022
Remyelination
therapies,
which
are
currently
under
development,
have
a
great
potential
to
delay,
prevent
or
even
reverse
disability
in
multiple
sclerosis
patients.
Several
models
available
study
the
effectiveness
of
novel
compounds
vivo,
among
is
cuprizone
model.
This
model
characterized
by
toxin-induced
demyelination,
followed
endogenous
remyelination
after
cessation
intoxication.
Due
its
high
reproducibility
and
ease
use,
this
enjoys
popularity
various
research
industrial
groups.
In
review
article,
we
will
summarize
recent
findings
using
discuss
some
identified
promote
