Alzheimer’s disease and sleep disorders: a bidirectional relationship
Neuroscience,
Год журнала:
2024,
Номер
557, С. 12 - 23
Опубликована: Авг. 11, 2024
Alzheimer's
disease
(AD)
is
the
most
prevalent
dementia,
pathologically
featuring
abnormal
accumulation
of
amyloid-β
(Aβ)
and
hyperphosphorylated
tau,
while
sleep,
divided
into
rapid
eye
movement
sleep
(REM)
nonrapid
(NREM),
plays
a
key
role
in
consolidating
social
spatial
memory.
Emerging
evidence
has
revealed
that
disorders
such
as
circadian
disturbances
disruption
neuronal
rhythm
activity
are
considered
both
candidate
risks
consequence
AD,
suggesting
bidirectional
relationship
between
AD.
This
review
will
firstly
grasp
basic
knowledge
AD
pathogenesis,
then
highlight
macrostructural
microstructural
alteration
along
with
progression,
explain
interaction
Aβ
which
two
critical
neuropathological
processes
well
neuroinflammation
finally
introduce
several
methods
enhancement
strategies
to
reduce
AD-associated
neuropathology.
Although
theories
about
relevant
therapeutic
mice
have
been
developed
recent
years,
human
still
limited.
More
studies
on
how
effectively
ameliorate
pathology
patients
by
what
specific
roles
play
needed.
Язык: Английский
Structural inequality linked to brain volume and network dynamics in aging and dementia across the Americas
Nature Aging,
Год журнала:
2024,
Номер
unknown
Опубликована: Дек. 27, 2024
Язык: Английский
Structural inequality and temporal brain dynamics across diverse samples
Clinical and Translational Medicine,
Год журнала:
2024,
Номер
14(10)
Опубликована: Окт. 1, 2024
Язык: Английский
Social and non-social working memory in neurodegeneration
Neurobiology of Disease,
Год журнала:
2023,
Номер
183, С. 106171 - 106171
Опубликована: Май 30, 2023
Although
social
functioning
relies
on
working
memory,
whether
a
social-specific
mechanism
exists
remains
unclear.
This
undermines
the
characterization
of
neurodegenerative
conditions
with
both
memory
and
deficits.
We
assessed
domain-specificity
across
behavioral,
electrophysiological,
neuroimaging
dimensions
in
245
participants.
A
novel
task
involving
non-social
stimuli
three
load
levels
was
controls
different
recognized
impairments
in:
cognition
(behavioral-variant
frontotemporal
dementia);
general
(Alzheimer's
disease);
unspecific
patterns
(Parkinson's
disease).
also
examined
resting-state
theta
oscillations
functional
connectivity
correlates
domain-specificity.
Results
all
groups
together
evidenced
increased
demands
for
associated
frontocinguloparietal
salience
network
connectivity.
Canonical
frontal
executive-default
mode
anticorrelation
indexed
stimuli.
Behavioral-variant
dementia
presented
generalized
deficits
related
to
posterior
oscillations,
linked
In
Alzheimer's
disease,
were
temporoparietal
executive
network.
Parkinson's
disease
showed
spared
performance
canonical
brain
correlates.
Findings
support
disease-selective
pathophysiological
mechanisms.
Язык: Английский
The “psychiatric” neuron: the psychic neuron of the cerebral cortex, revisited
L. Taylor Flynn,
Nadia N. Bouras,
Volodar M. Migovich
и другие.
Frontiers in Human Neuroscience,
Год журнала:
2024,
Номер
18
Опубликована: Март 18, 2024
Nearly
25
years
ago,
Dr.
Patricia
Goldman-Rakic
published
her
review
paper,
“The
‘Psychic’
Neuron
of
the
Cerebral
Cortex,”
outlining
circuit-level
dynamics,
neurotransmitter
systems,
and
behavioral
correlates
pyramidal
neurons
in
cerebral
cortex,
particularly
as
they
relate
to
working
memory.
In
decades
since
release
this
existing
literature
our
understanding
neuron
have
increased
tremendously,
research
is
still
underway
better
characterize
role
both
healthy
psychiatric
disease
states.
review,
we
revisit
Goldman-Rakic’s
characterization
neuron,
focusing
on
prefrontal
cortex
(PFC)
their
Specifically,
examine
PFC
intersection
memory
social
function
describe
how
deficits
may
actually
underlie
pathophysiology
dysfunction
We
briefly
cortico-cortical
corticothalamic
connections
between
non-PFC
brain
regions,
well
microcircuit
dynamics
interneurons,
these
macro-
microcircuits
maintenance
excitatory/inhibitory
balance
for
function.
Finally,
discuss
consequences
when
circuits
are
dysfunctional,
emphasizing
resulting
states
with
known
dysfunction.
Язык: Английский
Future Therapeutic Strategies for Alzheimer’s Disease: Focus on Behavioral and Psychological Symptoms
International Journal of Molecular Sciences,
Год журнала:
2024,
Номер
25(21), С. 11338 - 11338
Опубликована: Окт. 22, 2024
Alzheimer's
disease
(AD)
is
a
progressive,
degenerative
brain
disorder
that
impairs
memory
and
thinking
skills,
leading
to
significant
economic
humanistic
burdens.
It
associated
with
various
neuropsychiatric
symptoms
(NPS)
such
as
anxiety,
agitation,
depression,
aggression,
apathy,
psychosis.
NPSs
are
common
in
patients
AD,
affecting
up
97%
of
individuals
diagnosed
AD.
The
severity
NPS
linked
progression
cognitive
decline.
leads
increased
morbidity,
mortality,
caregiver
burden,
earlier
nursing
home
placement,
higher
healthcare
costs.
Despite
their
impact,
clinical
research
on
AD
limited.
In
settings,
accurately
distinguishing
diagnosing
related
remains
challenge.
Additionally,
conventional
treatments
for
often
ineffective,
highlighting
the
need
new
therapies
target
these
specific
symptoms.
Understanding
comorbidities
can
aid
early
diagnosis
better
management
this
review,
we
provide
summary
neurological
psychiatric
candidates
under
development
treatment
based
therapeutic
targets
mechanisms.
On
top
studied
so
far,
review
adds
recent
advancements
understanding
social
functional
impairment
This
also
provides
information
contribute
advancement
studies
translational
field
by
emphasizing
mechanisms
action
focused
AD-related
rather
than
targeted
drug
development.
Above
all,
considering
relative
lack
despite
importance
clinical,
medical,
research,
it
may
increase
interest
its
pathophysiological
mechanisms,
potential
molecules
antioxidant
potential.
Язык: Английский