Future Therapeutic Strategies for Alzheimer’s Disease: Focus on Behavioral and Psychological Symptoms DOI Open Access
Kyoung Ja Kwon, Hahn Young Kim, Seol‐Heui Han

et al.

International Journal of Molecular Sciences, Journal Year: 2024, Volume and Issue: 25(21), P. 11338 - 11338

Published: Oct. 22, 2024

Alzheimer's disease (AD) is a progressive, degenerative brain disorder that impairs memory and thinking skills, leading to significant economic humanistic burdens. It associated with various neuropsychiatric symptoms (NPS) such as anxiety, agitation, depression, aggression, apathy, psychosis. NPSs are common in patients AD, affecting up 97% of individuals diagnosed AD. The severity NPS linked progression cognitive decline. leads increased morbidity, mortality, caregiver burden, earlier nursing home placement, higher healthcare costs. Despite their impact, clinical research on AD limited. In settings, accurately distinguishing diagnosing related remains challenge. Additionally, conventional treatments for often ineffective, highlighting the need new therapies target these specific symptoms. Understanding comorbidities can aid early diagnosis better management this review, we provide summary neurological psychiatric candidates under development treatment based therapeutic targets mechanisms. On top studied so far, review adds recent advancements understanding social functional impairment This also provides information contribute advancement studies translational field by emphasizing mechanisms action focused AD-related rather than targeted drug development. Above all, considering relative lack despite importance clinical, medical, research, it may increase interest its pathophysiological mechanisms, potential molecules antioxidant potential.

Language: Английский

Alzheimer’s disease and sleep disorders: a bidirectional relationship DOI Creative Commons
J Chen,

Guoping Peng,

Binggui Sun

et al.

Neuroscience, Journal Year: 2024, Volume and Issue: 557, P. 12 - 23

Published: Aug. 11, 2024

Alzheimer's disease (AD) is the most prevalent dementia, pathologically featuring abnormal accumulation of amyloid-β (Aβ) and hyperphosphorylated tau, while sleep, divided into rapid eye movement sleep (REM) nonrapid (NREM), plays a key role in consolidating social spatial memory. Emerging evidence has revealed that disorders such as circadian disturbances disruption neuronal rhythm activity are considered both candidate risks consequence AD, suggesting bidirectional relationship between AD. This review will firstly grasp basic knowledge AD pathogenesis, then highlight macrostructural microstructural alteration along with progression, explain interaction Aβ which two critical neuropathological processes well neuroinflammation finally introduce several methods enhancement strategies to reduce AD-associated neuropathology. Although theories about relevant therapeutic mice have been developed recent years, human still limited. More studies on how effectively ameliorate pathology patients by what specific roles play needed.

Language: Английский

Citations

7
Structural inequality linked to brain volume and network dynamics in aging and dementia across the Americas DOI

Agustina Legaz,

Florencia Altschuler, Raúl González-Gómez

et al.

Nature Aging, Journal Year: 2024, Volume and Issue: unknown

Published: Dec. 27, 2024

Language: Английский

Citations

7
Structural inequality and temporal brain dynamics across diverse samples DOI Creative Commons
Sandra Báez, Hernán Hernandez, Sebastián Moguilner

et al.

Clinical and Translational Medicine, Journal Year: 2024, Volume and Issue: 14(10)

Published: Oct. 1, 2024

Language: Английский

Citations

4
Social and non-social working memory in neurodegeneration DOI Creative Commons

Agustina Legaz,

Pavel Prado, Sebastián Moguilner

et al.

Neurobiology of Disease, Journal Year: 2023, Volume and Issue: 183, P. 106171 - 106171

Published: May 30, 2023

Although social functioning relies on working memory, whether a social-specific mechanism exists remains unclear. This undermines the characterization of neurodegenerative conditions with both memory and deficits. We assessed domain-specificity across behavioral, electrophysiological, neuroimaging dimensions in 245 participants. A novel task involving non-social stimuli three load levels was controls different recognized impairments in: cognition (behavioral-variant frontotemporal dementia); general (Alzheimer's disease); unspecific patterns (Parkinson's disease). also examined resting-state theta oscillations functional connectivity correlates domain-specificity. Results all groups together evidenced increased demands for associated frontocinguloparietal salience network connectivity. Canonical frontal executive-default mode anticorrelation indexed stimuli. Behavioral-variant dementia presented generalized deficits related to posterior oscillations, linked In Alzheimer's disease, were temporoparietal executive network. Parkinson's disease showed spared performance canonical brain correlates. Findings support disease-selective pathophysiological mechanisms.

Language: Английский

Citations

6
The “psychiatric” neuron: the psychic neuron of the cerebral cortex, revisited DOI Creative Commons

L. Taylor Flynn,

Nadia N. Bouras,

Volodar M. Migovich

et al.

Frontiers in Human Neuroscience, Journal Year: 2024, Volume and Issue: 18

Published: March 18, 2024

Nearly 25 years ago, Dr. Patricia Goldman-Rakic published her review paper, “The ‘Psychic’ Neuron of the Cerebral Cortex,” outlining circuit-level dynamics, neurotransmitter systems, and behavioral correlates pyramidal neurons in cerebral cortex, particularly as they relate to working memory. In decades since release this existing literature our understanding neuron have increased tremendously, research is still underway better characterize role both healthy psychiatric disease states. review, we revisit Goldman-Rakic’s characterization neuron, focusing on prefrontal cortex (PFC) their Specifically, examine PFC intersection memory social function describe how deficits may actually underlie pathophysiology dysfunction We briefly cortico-cortical corticothalamic connections between non-PFC brain regions, well microcircuit dynamics interneurons, these macro- microcircuits maintenance excitatory/inhibitory balance for function. Finally, discuss consequences when circuits are dysfunctional, emphasizing resulting states with known dysfunction.

Language: Английский

Citations

1
Future Therapeutic Strategies for Alzheimer’s Disease: Focus on Behavioral and Psychological Symptoms DOI Open Access
Kyoung Ja Kwon, Hahn Young Kim, Seol‐Heui Han

et al.

International Journal of Molecular Sciences, Journal Year: 2024, Volume and Issue: 25(21), P. 11338 - 11338

Published: Oct. 22, 2024

Alzheimer's disease (AD) is a progressive, degenerative brain disorder that impairs memory and thinking skills, leading to significant economic humanistic burdens. It associated with various neuropsychiatric symptoms (NPS) such as anxiety, agitation, depression, aggression, apathy, psychosis. NPSs are common in patients AD, affecting up 97% of individuals diagnosed AD. The severity NPS linked progression cognitive decline. leads increased morbidity, mortality, caregiver burden, earlier nursing home placement, higher healthcare costs. Despite their impact, clinical research on AD limited. In settings, accurately distinguishing diagnosing related remains challenge. Additionally, conventional treatments for often ineffective, highlighting the need new therapies target these specific symptoms. Understanding comorbidities can aid early diagnosis better management this review, we provide summary neurological psychiatric candidates under development treatment based therapeutic targets mechanisms. On top studied so far, review adds recent advancements understanding social functional impairment This also provides information contribute advancement studies translational field by emphasizing mechanisms action focused AD-related rather than targeted drug development. Above all, considering relative lack despite importance clinical, medical, research, it may increase interest its pathophysiological mechanisms, potential molecules antioxidant potential.

Language: Английский

Citations

0