Brain Communications,
Год журнала:
2024,
Номер
7(1)
Опубликована: Дек. 24, 2024
Abstract
With
the
ongoing
developments
in
field
of
anti-amyloid
therapy
for
Alzheimer’s
disease,
it
is
crucial
to
better
understand
longitudinal
associations
between
amyloid-β
deposition
and
altered
network
activity
living
human
brain.
We
included
110
cognitively
unimpaired
individuals
(67.9
±
5.7
years),
who
underwent
[18F]flutemetamol
(amyloid-β)-PET
imaging
resting-state
magnetoencephalography
(MEG)
recording
at
baseline
4-year
follow-up.
tested
MEG
measures
(oscillatory
power
functional
connectivity).
Next,
we
examined
relationship
measures,
as
well
deposition.
Finally,
assessed
changes
both
measures.
Analyses
were
performed
using
linear
mixed
models
corrected
age,
sex
family.
At
baseline,
orbitofrontal-posterior
cingulate
regions
(i.e.
early
disease
regions)
was
associated
with
higher
theta
(4–8
Hz)
(β
=
0.17,
P
<
0.01)
in-
lower
connectivity
[inverted
Joint
Permutation
Entropy
(JPEinv)
theta,
β
−0.24,
0.001]
these
regions,
whole-brain
beta
(13–30
−0.13,
0.05)
(JPEinv
−0.18,
0.001).
Whole-brain
0.05),
−0.21,
Baseline
also
predicted
future
oscillatory
slowing,
reflected
by
increased
over
time
across
whole
brain
0.11,
0.08,
0.001),
decreased
−0.04,
0.05).
a
reduction
rest
−0.07,
0.01).
not
Longitudinal
−0.19,
[corrected
amplitude
envelope
correlations
alpha
(8–13
Hz),
−0.22,
0.05].
relative
0.21,
Disruptions
appear
represent
consequences
emerging
individuals.
These
findings
suggest
role
neurophysiology
monitoring
progression
potential
treatment
effects
pre-clinical
disease.
Alzheimer s Research & Therapy,
Год журнала:
2023,
Номер
15(1)
Опубликована: Авг. 7, 2023
Abstract
Background
Alzheimer’s
dementia
(AD)
is
associated
with
electroencephalography
(EEG)
abnormalities
including
in
the
power
ratio
of
beta
to
theta
frequencies.
EEG
studies
mild
cognitive
impairment
(MCI)
have
been
less
consistent
identifying
such
abnormalities.
One
potential
reason
not
excluding
aperiodic
components,
which
are
cognition
than
periodic
components.
Here,
we
investigate
whether
and
components
disrupted
differently
AD
or
MCI
vs.
healthy
control
(HC)
individuals
a
based
beta/theta
differentiates
better
from
HC
groups
on
full
spectrum.
Methods
Data
were
collected
44
(mean
age
(SD)
=
69.1
(5.3)),
114
72.2
(7.5)),
41
75.7
(6.5))
participants.
Aperiodic
spectrum
compared
among
three
groups.
Receiver
operating
characteristic
curves
obtained
via
logistic
regression
classifications
used
distinguish
Last,
explored
relationships
between
performance
ratios
Results
did
differ
In
contrast,
participants
showed
an
increase
relative
powers
for
delta,
theta,
gamma
decrease
when
As
predicted,
group
differed
(Bonferroni
corrected
p
-value
0.036)
measured
over
occipital
region.
Classifiers
distinguished
participants,
outperformed
classifiers
EEG.
Beta/theta
comparable
their
association
cognition.
Conclusions
contrast
analysis,
periodic-based
analysis
shows
that
different
individuals.
Focusing
without
other
biological
markers
neurodegenerative
diseases
could
result
more
reliable
findings
separate
aging,
would
be
valuable
designing
preventative
interventions.
Alzheimer s & Dementia,
Год журнала:
2024,
Номер
20(9), С. 6316 - 6331
Опубликована: Июль 12, 2024
Abstract
INTRODUCTION
Despite
parallel
research
indicating
amyloid‐β
accumulation,
alterations
in
cortical
neurophysiological
signaling,
and
multi‐system
neurotransmitter
disruptions
Alzheimer's
disease
(AD),
the
relationships
between
these
phenomena
remains
unclear.
METHODS
Using
magnetoencephalography,
positron
emission
tomography,
an
atlas
of
19
neurotransmitters,
we
studied
alignment
alterations,
deposition,
neurochemical
gradients
cortex.
RESULTS
In
patients
with
mild
cognitive
impairment
AD,
changes
rhythms
were
topographically
aligned
cholinergic,
serotonergic,
dopaminergic
systems.
These
alignments
correlated
severity
clinical
impairments.
Additionally,
plaques
preferentially
deposited
along
boundaries,
influencing
how
align
muscarinic
acetylcholine
receptors.
Most
amyloid‐β‐neurochemical
alpha‐band
neuro‐physio‐chemical
replicated
independent
dataset
individuals
asymptomatic
accumulation.
DISCUSSION
Our
findings
demonstrate
that
AD
pathology
aligns
distribution
chemical
neuromodulator
systems
scales
severity,
implications
for
potential
pharmacotherapeutic
pathways.
Highlights
Changes
are
organized
boundaries.
The
strength
is
related
to
symptom
severity.
Deposition
(Aβ)
similar
Aβ
deposition
mediates
beta
cholinergic
replicate
participants
pre‐clinical
pathology.
Frontiers in Aging Neuroscience,
Год журнала:
2024,
Номер
16
Опубликована: Янв. 30, 2024
Background
Dementia
and
mild
cognitive
impairment
are
characterised
by
symptoms
of
decline,
which
typically
assessed
using
neuropsychological
assessments
(NPAs),
such
as
the
Mini-Mental
State
Examination
(MMSE)
Frontal
Assessment
Battery
(FAB).
Magnetoencephalography
(MEG)
is
a
novel
clinical
assessment
technique
that
measures
brain
activities
(summarised
oscillatory
parameters),
associated
with
impairment.
However,
relevance
MEG
regional
cerebral
blood
flow
(rCBF)
data
obtained
single-photon
emission
computed
tomography
(SPECT)
has
not
been
examined
datasets.
Therefore,
this
study
aimed
to
investigate
relationships
among
parameters,
clinically
validated
biomarkers
from
rCBF,
NPAs
outpatient
retrieved
hospital
records.
Methods
Clinical
64
individuals
mixed
pathological
backgrounds
were
analysed.
including
relative
power
(RP)
delta
high
gamma
bands,
mean
frequency,
individual
alpha
Shannon’s
spectral
entropy,
for
each
cortical
region.
For
SPECT
data,
three
parameters—‘
severity
’,
‘
extent
ratio
’—were
an
easy
z-score
imaging
system
(eZIS).
As
NPAs,
MMSE
FAB
scores
retrieved.
Results
parameters
correlated
eZIS
parameters.
The
Alzheimer’s
disease
pathology
reflected
in
theta
augmentation
slower
shift
peak.
Moreover,
found
reflect
NPAs.
Global
slowing
loss
diversity
neural
components
scores,
whereas
associations
between
sparse.
Conclusion
both
(i.e.
eZIS)
supporting
validity
symptomatic
indicators.
findings
indicate
various
characteristics
can
provide
valuable
information,
making
rich
resource
examinations
patients
impairments.
showed
no
correlations
results
contributed
better
understanding
electrophysiological
impairments,
will
help
facilitate
their
co-use
application,
thereby
improving
patient
care.
Psychosocial Intervention,
Год журнала:
2025,
Номер
34(1), С. 37 - 51
Опубликована: Янв. 1, 2025
Objective:
Mild
cognitive
impairment
(MCI)
has
been
recognized
as
a
window
of
opportunity
for
therapeutic
and
preventive
measures
to
slow
decline.
The
current
study
investigated
the
efficacy
virtual
reality
(VR)
cognitive-based
intervention
on
verbal
visuospatial
short-term
memory
(STM),
executive
functions
(EFs),
wellbeing
among
older
adults
with
without
MCI.
Method:
immersive
VR
comprised
eight
60-minute
sessions,
held
twice
week
over
span
30
days.
participants
consisted
31
non-MCI
in
experimental
group
(mean
age
±
SD
=
66.31
3.12
years),
29
MCI
68.19
5.03
control
64.97
3.35
years).
dependent
variables
were
assessed
by
using
battery
computerized
test,
well-being
people
questionnaire
resting-state
EEG.
A
repeated-measures
ANCOVA
was
employed
examine
effects
developed
intervention.
Results:
Significant
improvements
observed
both
STMs
EFs
following
intervention,
indicated
behavioral
EEG
findings,
ranging
from
small
large
effect
sizes
(i.e.,
.05-.17).
However,
enhanced
specifically
group,
F(2,
87)
6.78,
p
.01,
.11.
Conclusions:
present
findings
lend
support
interventions
across
clinical
non-clinical
populations.
These
results
underscore
immediate
impact
multimodal
assessments,
including
neurophysiological
changes,
cognitive,
outcomes.
Proceedings of the National Academy of Sciences,
Год журнала:
2025,
Номер
122(6)
Опубликована: Фев. 4, 2025
Meditation
is
an
accessible
mental
practice
associated
with
emotional
regulation
and
well-being.
Loving-kindness
meditation
(LKM),
a
specific
subtype
of
meditative
practice,
involves
focusing
one’s
attention
on
thoughts
well-being
for
oneself
others.
has
been
proven
to
be
beneficial
in
variety
settings,
including
therapeutic
applications,
but
the
neural
activity
underlying
practices
their
positive
effects
are
not
well
understood.
It
difficult
understand
contribution
deep
limbic
structures
given
difficulty
studying
directly
human
brain.
Here,
we
leverage
unique
patient
population,
epilepsy
patients
chronically
implanted
responsive
neurostimulation
devices
that
allow
chronic,
invasive
electrophysiology
recording
investigate
physiological
correlates
LKM
amygdala
hippocampus
novice
meditators.
We
find
LKM-associated
changes
were
periodic,
aperiodic,
features
activity.
was
increase
γ
(30
55
Hz)
power
alternation
duration
β
(13
30
oscillatory
bursts
both
hippocampus,
two
regions
mood
disorders.
These
findings
reveal
nature
LKM-induced
modulation
first-time
Exploration of neuroscience,
Год журнала:
2025,
Номер
4
Опубликована: Март 24, 2025
Aim:
Alzheimer’s
disease
(AD)
is
associated
with
several
electrophysiological
biomarkers.
These
biomarkers
are
global
decline
in
cognition
and
a
diagnosis
of
AD.
However,
specific
biomarker
not
characterized
as
normal-functioning
older
adults
convert
to
The
longitudinal
retrospective
study
was
conducted
describe
an
indicator
for
AD
the
continuum
over
2-year
period.
Methods:
54
community-residing
adults,
ranging
from
normal
functioning
All
initial
follow-up
evaluations
were
completed
New
York
University
Brain
Research
Laboratories,
overall
assessments
Global
Deterioration
Scale
(GDS)
Aging
Dementia
Center.
Data
included
measurements
GDS
raw
resting-state
electroencephalogram
(rsEEG),
which
transformed
into
quantitative
EEG
(qEEG)
data.
analysis
consisted
descriptive
statistics
Kruskal-Wallis
test.
level
significance
0.05
moderate
effect
size.
Topographic
brain
images
displayed
Results:
A
consistently
increasing
rsEEG
theta
frequency
(P
≤
0.01)
occurred
converted
across
all
stages
frontal
posterior
regions
progressive
decline.
No
discernible
consistent
changes
observed
delta,
alpha,
or
beta
frequencies
stages.
differed
at
baseline
0.01).
increased
Conclusions:
may
be
within
continuum.
This
will
enhance
assessment
risk,
onset,
progression
potentially
inform
treatment
