EPB41L4A-AS1 modulates Aβ clearance by regulating autophagy-related gene expression DOI Creative Commons
Ziqiang Wang, Ruomei Wang, Lixin Niu

и другие.

Research Square (Research Square), Год журнала: 2023, Номер unknown

Опубликована: Ноя. 1, 2023

Abstract Alzheimer's disease (AD) is the most common neurodegenerative disorder characterized by deposition of β-amyloid (Aβ) plaques. Aβ generated from cleavage amyloid precursor protein β and γ-secretases cleared neuroglial cells mediated autophagy. The imbalance intracellular generation clearance causative factor for AD pathogenesis. However, exact underlying molecular mechanisms remain unclear. Our previous study reported that EPB41L4A-AS1 an aging-related long non-coding RNA (lncRNA) repressed in patients with AD. In this study, we found downregulated inhibited mediated-Aβ decreasing expression levels multiple autophagy-related genes. We regulates general control amino acid synthesis 5-like 2, important histone acetyltransferase, thus affecting acetylation, crotonylation, lactylation near transcription start site genes, ultimately influencing their transcription. Collectively, reveals as AD-related lncRNA via mediating provides insights into epigenetic regulatory mechanism gene

Язык: Английский

lncRNA NEAT1: Key player in neurodegenerative diseases DOI Creative Commons
Kun Li, Ziqiang Wang

Ageing Research Reviews, Год журнала: 2023, Номер 86, С. 101878 - 101878

Опубликована: Фев. 3, 2023

Neurodegenerative diseases are the most common causes of disability worldwide. Given their high prevalence, devastating symptoms, and lack definitive diagnostic tests, there is an urgent need to identify potential biomarkers new therapeutic targets. Long non-coding RNAs (lncRNAs) have recently emerged as powerful regulatory molecules in neurodegenerative diseases. Among them, lncRNA nuclear paraspeckle assembly transcript 1 (NEAT1) has been reported be upregulated Alzheimer's disease (AD), Parkinson's (PD), Huntington's (HD), amyotrophic lateral sclerosis (ALS). However, whether this part a protective or harmful mechanism still unclear. This review summarizes our current knowledge role NEAT1 its association with characteristic aggregation misfolded proteins: amyloid-β tau AD, α-synuclein PD, mutant huntingtin HD, TAR DNA-binding protein-43 fused sarcoma/translocated liposarcoma ALS. The aim stimulate further research on more precise effective treatments for

Язык: Английский

Процитировано

75
Molecular landscape of LncRNAs in bladder cancer: From drug resistance to novel LncRNA-based therapeutic strategies DOI Open Access

Amirreza Mehmandar‐Oskuie,

Kasra Jahankhani,

Arman Rostamlou

и другие.

Biomedicine & Pharmacotherapy, Год журнала: 2023, Номер 165, С. 115242 - 115242

Опубликована: Июль 31, 2023

Bladder cancer (BC) is a common and serious type of that ranks among the top ten most prevalent malignancies worldwide. Due to high occurrence rate BC, aggressive nature cells, their resistance medication, managing this disease has become growing challenge in clinical care. Long noncoding RNAs (lncRNAs) are group RNA transcripts do not code for proteins more than 200 nucleotides length. They play significant role controlling cellular pathways molecular interactions during onset, development progression different types cancers. Recent advancements high-throughput gene sequencing technology have led identification various differentially expressed lncRNAs which indicate abnormal expression. In review, we summarize these been found impact several functions related including proliferation, cell growth, migration, metastasis, apoptosis, epithelial-mesenchymal transition, chemo- radio-resistance. Additionally, may improve prognosis prediction BC patients, indicating future use them as prognostic diagnostic biomarkers patients. This review highlights genetic tools anti-tumor agents, such CRISPR/Cas systems, siRNA, shRNA, antisense oligonucleotides, vectors, created preclinical models. interest using based on positive research findings.

Язык: Английский

Процитировано

30
Epigenetic programing of cancer stemness by transcription factors-non-coding RNAs interactions DOI Creative Commons
Reem Khaled M.E. Alsayed,

Khalid Sultan A. M. Sheikhan,

Majid Alam

и другие.

Seminars in Cancer Biology, Год журнала: 2023, Номер 92, С. 74 - 83

Опубликована: Апрель 11, 2023

Cancer 'stemness' is fundamental to cancer existence. It defines the ability of cells indefinitely perpetuate as well differentiate. stem cell populations within a growing tumor also help evade inhibitory effects chemo- radiation-therapies, in addition playing an important role metastases. NF-κB and STAT-3 are representative transcription factors (TFs) that have long been associated with stemness, thus presenting attractive targets for therapy. The interest non-coding RNAs (ncRNAs) recent years has provided further insight into mechanisms by which TFs influence characteristics. There evidence direct regulation ncRNAs, such as, microRNAs (miRNAs), (lncRNAs) circular (circRNAs), vice versa. Additionally, TF-ncRNAs regulations often indirect, involving ncRNA-target genes or sponging other ncRNA species individual ncRNAs. information rapidly evolving this review provides comprehensive interactions implications on stemness response therapies. Such knowledge will uncover many levels tight control providing novel opportunities therapy process.

Язык: Английский

Процитировано

21
Dysregulated Circular RNA and Long non-coding RNA-Mediated Regulatory Competing Endogenous RNA Networks (ceRNETs) in Ovarian and Cervical Cancers: A Non-coding RNA-Mediated Mechanism of Chemotherapeutic Resistance with New Emerging Clinical Capacities DOI
Danial Amiri Manjili, Fatemeh Naghdi Babaei,

Tayebeh Younesirad

и другие.

Archives of Biochemistry and Biophysics, Год журнала: 2025, Номер unknown, С. 110389 - 110389

Опубликована: Март 1, 2025

Язык: Английский

Процитировано

1
EPB41L4A-AS1 is required to maintain basal autophagy to modulates Aβ clearance DOI Creative Commons
Ziqiang Wang, Ruomei Wang, Lixin Niu

и другие.

npj Aging, Год журнала: 2024, Номер 10(1)

Опубликована: Май 4, 2024

Abstract Alzheimer’s disease (AD) is the most common neurodegenerative disorder characterized by deposition of β-amyloid (Aβ) plaques. Aβ generated from cleavage amyloid precursor protein β and γ-secretases cleared neuroglial cells mediated autophagy. The imbalance intracellular generation clearance causative factor for AD pathogenesis. However, exact underlying molecular mechanisms remain unclear. Our previous study reported that EPB41L4A-AS1 an aging-related long non-coding RNA (lncRNA) repressed in patients with AD. In this study, we found downregulated inhibited mediated-Aβ decreasing expression levels multiple autophagy-related genes. We regulates general control amino acid synthesis 5-like 2, important histone acetyltransferase, thus affecting acetylation, crotonylation, lactylation near transcription start site genes, ultimately influencing their transcription. Collectively, reveals as AD-related lncRNA via mediating provides insights into epigenetic regulatory mechanism gene

Язык: Английский

Процитировано

5
DARS-AS1: A Vital Oncogenic LncRNA Regulator with Potential for Cancer Prognosis and Therapy DOI Creative Commons
Jian Shu,

Kejiang Xia,

Hongliang Luo

и другие.

International Journal of Medical Sciences, Год журнала: 2024, Номер 21(3), С. 571 - 582

Опубликована: Янв. 1, 2024

DARS-AS1, short for Aspartyl-tRNA synthetase antisense RNA 1, has emerged as a pivotal player in cancers.Upregulation of this lncRNA is recurrent phenomenon observed across various cancer types, where it predominantly assumes oncogenic roles, exerting influence on multiple facets tumor cell biology.This aberrant expression DARS-AS1 triggered extensive research investigations, aiming to unravel its roles and clinical values cancer.In review, we elucidate the significant correlation between dysregulated adverse survival prognoses patients, drawing from existing literature pan-cancer analyses The Cancer Genome Atlas (TCGA).Additionally, provide comprehensive insights into diverse functions cancers.Our review encompasses elucidation molecular mechanisms, ceRNA networks, functional mediators, signaling pathways, well involvement therapy resistance, coupled with latest advancements DARS-AS1-related research.These recent updates enrich our comprehension role played by cancer, thereby paving way future applications DARS-AS1-targeted strategies prognosis evaluation therapeutic interventions.This furnishes valuable advance ongoing efforts combating effectively.

Язык: Английский

Процитировано

3
Non-Coding RNAs in Urinary Bladder Cancer Microenvironment: Diagnostic, Therapeutic, and Prognostic Perspective DOI
Enas A. El Saftawy, Basma Emad Aboulhoda,

Marwa Ali Abd Elkhalek

и другие.

Pathology - Research and Practice, Год журнала: 2025, Номер 266, С. 155815 - 155815

Опубликована: Янв. 9, 2025

Язык: Английский

Процитировано

0
LINC01559: roles, mechanisms, and clinical implications in human cancers DOI
Shuwen Zhang, Xin Lan, Lei Liu

и другие.

Human Cell, Год журнала: 2025, Номер 38(3)

Опубликована: Апрель 9, 2025

Язык: Английский

Процитировано

0
A prognostic model for head and neck squamous cell carcinoma based on a ceRNA network to predict radiotherapy response DOI

Weixia Liu,

Yuening Zhang,

Yuan Yang

и другие.

Journal of Radiation Research and Applied Sciences, Год журнала: 2025, Номер 18(2), С. 101501 - 101501

Опубликована: Апрель 19, 2025

Язык: Английский

Процитировано

0
miRNA, lncRNA and circRNA: targeted molecules with therapeutic promises in Mycoplasma pneumoniae infection DOI
Tian Gan,

Jianwei Yu,

Jun He

и другие.

Archives of Microbiology, Год журнала: 2023, Номер 205(8)

Опубликована: Июль 21, 2023

Язык: Английский

Процитировано

8