Scaffolds for drug delivery and tissue engineering: The role of genetics

Journal of Controlled Release, Год журнала: 2023, Номер 359, С. 207 - 223

Опубликована: Июнь 8, 2023

Язык: Английский

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Designing a High-Sensitivity Microscale Triple-Band Biosensor Based on Terahertz MTMs to Provide a Perfect Absorber for Non-Melanoma Skin Cancer Diagnostic

IEEE photonics journal, Год журнала: 2024, Номер 16(2), С. 1 - 13

Опубликована: Март 27, 2024

non-melanoma skin cancer (NMSC) is among the most prevalent forms of originating in top layer skin, with basal cell carcinoma (BCC) and squamous (SCC) being its primary categories. While both types are highly treatable, success treatment hinges on early diagnosis. Early-stage NMSC detection can be achieved through clinical examination, typically involving visual inspection. An alternative, albeit invasive, method a biopsy. Microwave imaging has gained prominence for non-invasive various cancers, leveraging distinct dielectric properties healthy malignant tissues to discriminate tumors categorize them as benign or malignant. Recent studies demonstrate potential terahertz (THz) spectroscopy detecting biomarkers by aligning electromagnetic wave frequencies low THz range (0.1 10 THz) resonant biomolecules, such proteins. This study proposes an innovative microscale biosensor designed operate high-sensitivity efficient diagnosis cancer. By incorporating meticulously metamaterial layers, sensor's absorption controlled, critical aspect discriminating between normal NMSC-affected skin. In particular, interaction waves, influenced unique vibrational resonances molecules within tissue, crucial propagation scattering. Extensive numerical showcased suitability proposed diagnosis, illustrated specific case studies. These findings hold pave way further development microwave-imaging-based techniques other

Язык: Английский

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Natural Compounds in Non-Melanoma Skin Cancer: Prevention and Treatment

Molecules, Год журнала: 2024, Номер 29(3), С. 728 - 728

Опубликована: Фев. 4, 2024

The elevated occurrence of non-melanoma skin cancer (NMSC) and the adverse effects associated with available treatments adversely impact quality life in multiple dimensions. In connection this, there is a necessity for alternative approaches characterized by increased tolerance lower side effects. Natural compounds could be employed due to their safety profile effectiveness inflammatory neoplastic diseases. These anti-cancer drugs are often derived from natural sources such as marine, zoonotic, botanical origins. should exhibit anti-carcinogenic actions through various pathways, influencing apoptosis potentiation, cell proliferation inhibition, metastasis suppression. This review provides an overview used chemotherapies, chemoprevention, promotion regeneration, including polyphenolic compounds, flavonoids, vitamins, alkaloids, terpenoids, isothiocyanates, cannabinoids, carotenoids, ceramides.

Язык: Английский

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Size-dependent effects of niosomes on the penetration of methotrexate in skin layers

Future Journal of Pharmaceutical Sciences, Год журнала: 2024, Номер 10(1)

Опубликована: Март 27, 2024

Abstract Background Niosomes hold promise as drug delivery systems for cancer treatment, with niosome size impacting stability, biodistribution, and effectiveness. This study optimized methotrexate (MTX)-loaded formulation by studying the effects of components processing conditions on size. The niosomes was made thin-film hydration technique. Results (NIO 17) a 6:2:2 ratio span 60, soya PC, cholesterol achieved 55.05% encapsulation, particle 597.2 nm, PDI 0.49, zeta potential − 23.3 mV. compatibility lipids confirmed via Fourier transform infrared spectroscopy, transmission electron microscopy revealed spherical, well-dispersed vesicles. Differential scanning calorimetry indicated conversion or entrapment within In vitro release exhibited sustained pattern an initial burst. NIO 17 showed potent anti-cancer activity against B16-F10 cells (GI50: 38.7176 μg/mL). Ex vivo studies suggest tailoring (597.2–982.3 nm) to target specific skin depths (0–38 μm) enhanced localized delivery. Conclusions demonstrates methotrexate-loaded novel therapy approach, highlighting transdermal 17. Further research is necessary explore its clinical translation. Graphical abstract

Язык: Английский

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Utilização de lipossomas no diagnóstico e tratamento do câncer de pele não melanoma: uma revisão integrativa

Research Society and Development, Год журнала: 2022, Номер 11(10), С. e435111032984 - e435111032984

Опубликована: Авг. 6, 2022

O câncer de pele não melanoma (CPNM) é o tipo com maior incidência e tem sido classificado em: carcinoma basocelular (CBC) espinocelular (CEC). objetivo do presente estudo foi avaliar, por meio uma revisão bibliográfica integrativa, a utilização lipossomas no diagnóstico tratamento CPNM. A estratégia busca dos artigos científicos realizada através investigação nas bases dados Scopus, Pubmed Web Of Science, acessando Portal Periódicos Capes, utilizando os descritores em inglês “Liposomes” AND “non-melanoma” “skin” “cancer” “(treatment OR diagnosis)”. Para auxiliar processo análise artigos, utilizou-se plataforma Rayyan. Após análise, 7 publicações foram selecionadas para compor essa revisão, identificando: títulos, autores, objetivos, principais resultados, conclusões temas abordados nos estudos. Observou-se que maioria eixos temáticos abordaram sistemas lipossomais potencialização drogas capacidade antitumoral. Os demais discorriam sobre na detecção das lesões associadas ao Câncer Pele Não Melanoma e, também, aplicação nanocarreadores terapias anticâncer, sobretudo terapia fotodinâmica. Baseado nisso, concluiu-se possuem versátil CPNM, indo diagnóstico, entanto, as pesquisas acerca da voltada esse tema, são escassas recentes. Dessa forma, esta extrema relevância se possa direcionar elaboração novos estudos visem aprimorar técnicas já mencionadas desenvolver novas tema.

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Innovative Topical Patches for Non-Melanoma Skin Cancer: Current Challenges and Key Formulation Considerations

Pharmaceutics, Год журнала: 2023, Номер 15(11), С. 2577 - 2577

Опубликована: Ноя. 3, 2023

Non-melanoma skin cancer (NMSC) is the most prevalent malignancy worldwide, with approximately 6.3 million new cases worldwide in 2019. One of key management strategies for NMSC a topical treatment usually utilised localised and early-stage disease owing to its non-invasive nature. However, efficacy agents often hindered by poor drug penetration patient adherence. Therefore, various research groups have employed advanced delivery systems, including patches overcome problem conventional treatments. This review begins an overview as well current landscape treatments NMSC, specifically focusing on emerging technology patches. A detailed discussion their potential limitations existing therapies will then follow. Most importantly, best our knowledge, this work unprecedentedly combines discusses all advancements innovative NMSC. In addition this, authors present insights into considerations trends construction these meant researchers clinicians consider utilising patch systems clinical trials toward interventions

Язык: Английский

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Nanoparticle Delivery Systems for Skin-Localized Chemotherapy in Non-Melanoma Skin Cancers

Open Journal of Regenerative Medicine, Год журнала: 2025, Номер 14(01), С. 1 - 18

Опубликована: Янв. 1, 2025

Язык: Английский

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A review of sunscreen in the prevention of skin cancer

Journal of Oncology Pharmacy Practice, Год журнала: 2025, Номер unknown

Опубликована: Март 24, 2025

Objective Despite the reported benefits of sunscreen use in preventing skin cancer, overall protection from melanoma and non-melanoma cancers putatively reflects frequency type. Herein, we review current knowledge regarding sunscreen's effectiveness at averting development cancers. Data sources We conducted an extensive PubMed search comprising several articles on topic prevention with specific terms that included usage, side effects. summary Several observational, cohort studies randomized controlled trials have underscored forestalling In particular, incidence squamous-cell carcinoma is reduced, although effect basal-cell relatively less pronounced. Conclusions The implications this study indicate reduces deriving intended contingent upon type adherence to recommended guidelines. primary effects include dermal irritation rash; since there some indication UV filter-based sunscreens may harbor carcinogenic properties, clinicians should advise their patients sunscreen, not mention use.

Язык: Английский

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Global burden of non-melanoma skin cancers among older adults: a comprehensive analysis using machine learning approaches

Scientific Reports, Год журнала: 2025, Номер 15(1)

Опубликована: Май 1, 2025

Non-melanoma skin cancers (NMSCs), including basal cell carcinoma (BCC) and squamous (SCC), have shown significant global increases in burden, particularly among older adults, with wide regional, gender, socio-demographic disparities. However, no previous study has comprehensively analyzed these trends using integrated multi-model approaches. A comprehensive analysis of non-melanoma cancer (NMSC) data from 1990 to 2021 was performed, trend analysis, frontier decomposition compare the burden (SCC) across regions, genders, groups. Temporal incidence, prevalence, disability-adjusted life years (DALYs) were identified epidemiological techniques. To forecast future disease 2022 2050, eight machine learning models (Prophet, ARIMA, TBATS, ElasticNet, ETS, VAR, HoltWinters, Theta) applied, most optimal predictive for BCC SCC selected based on performance metrics. From 2021, adults increased substantially. The incidence rose by 291.85%, an age-standardized rate (ASR) increase 62.79%, while 322.77%, a 67.42% rise ASR. High Socio-Demographic Index (SDI) regions showed largest ASR (102.73%) (107.31%), whereas low SDI demonstrated more modest changes or declines (BCC: - 2.86%, SCC: 3.08%). Gender disparities observed, males accounting 56.47% cases globally. Decomposition revealed that population growth primary driver NMSC contributing 62.52-83.92% DALYs, accounted up 52.2% high regions. Frontier highlighted regional disparities, such as North America, exhibiting highest rates (2,923.22 per 100,000) (1,805.33 100,000), like sub-Saharan Africa, minimal burdens near values. Finally, forecasting 2050 predicted slight decrease (from 314.00 308.73 157.67 148.16 100,000). Disability-adjusted are projected decline (79.32 75.20 but slightly (0.136 0.151 These projections underscore need tailored strategies address growing NMSC. NMSCs, underscores urgent prevention, resource allocation, management strategies. Machine learning-based approaches provide robust insights into challenges SCC.

Язык: Английский

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Cellulose based nanofiber-assisted stabilization of cationic ethosomes for skin penetration of bleomycin sulphate in the treatment of skin cancer

International Journal of Biological Macromolecules, Год журнала: 2025, Номер 311, С. 143933 - 143933

Опубликована: Май 4, 2025

Язык: Английский

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