Mapping structural neuroimaging trajectories in bipolar disorder: neurobiological and clinical implications

Biological Psychiatry, Год журнала: 2025, Номер unknown

Опубликована: Фев. 1, 2025

Язык: Английский

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Maternal Immune Activation and the Development of Dopaminergic Neurotransmission of the Offspring: Relevance for Schizophrenia and Other Psychoses

Frontiers in Psychiatry, Год журнала: 2020, Номер 11

Опубликована: Авг. 21, 2020

Prenatal infection has been linked to the development of schizophrenia (SCZ) in offspring, and work animal models indicates that this is occur through maternal inflammatory response triggered by infection. Several studies demonstrated acute episodes are sufficient trigger brain alterations adult especially mesolimbic dopamine (DA) system, involved pathophysiology other disorders involving psychosis. In current review, we synthesize literature on clinical implicating prenatal infectious events SCZ. Then summarize evidence from immune activation (MIA) behavioral molecular relevant for function DAergic system. Furthermore, discuss supporting involvement cytokines, such as interleukin 6 (IL-6) leptin (a hormone with effects inflammation) mediating MIA fetal brain, leading long-lasting offspring. particular, IL-6 offspring actions placenta, induction IL-17a, or triggering decrease non-heme iron (hypoferremia). Maternal very likely interacting additional genetic environmental risk factors SCZ; systematically investigating how these interactions produce specific phenotypes next step understanding etiology complex psychiatric disorders.

Язык: Английский

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Neural Correlates of the Risk for Schizophrenia and Bipolar Disorder: A Meta-analysis of Structural and Functional Neuroimaging Studies

Biological Psychiatry, Год журнала: 2022, Номер 92(5), С. 375 - 384

Опубликована: Март 4, 2022

Язык: Английский

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Resting-state functional connectivity and spontaneous brain activity in early-onset bipolar disorder: A review of functional Magnetic Resonance Imaging studies

Journal of Affective Disorders, Год журнала: 2022, Номер 311, С. 463 - 471

Опубликована: Май 14, 2022

Язык: Английский

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Examining the shared etiology of psychopathology with genome-wide association studies

Physiological Reviews, Год журнала: 2023, Номер 103(2), С. 1645 - 1665

Опубликована: Янв. 12, 2023

Genome-wide association studies (GWASs) have ushered in a new era of reproducible discovery psychiatric genetics. The field has now identified hundreds common genetic variants that are associated with mental disorders, and many them influence more than one disorder. By advancing the understanding causal biology underlying psychopathology, GWAS results poised to inform development novel therapeutics, stratification at-risk patients, perhaps even revision top-down classification systems psychiatry. Here, we provide concise review findings an emphasis on elucidated shared etiology summarizing insights at three levels analysis: 1) genome-wide architecture; 2) networks, pathways, gene sets; 3) individual variants/genes. Three themes emerge from these efforts. First, all phenotypes heritable, highly polygenic, influenced by pleiotropic incomplete penetrance. Second, highlight broad etiological roles neuronal biology, system-wide effects over localized effects, early neurodevelopment as critical period. Third, loci robustly multiple forms psychopathology harbor genes involved synaptic structure function. Finally, conclude our discussing implications hold for psychiatry, well expected challenges future directions next stage

Язык: Английский

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Low status, humiliation, dopamine and risk of schizophrenia

Psychological Medicine, Год журнала: 2023, Номер 53(3), С. 609 - 613

Опубликована: Янв. 25, 2023

The social defeat hypothesis of schizophrenia, which proposes that the chronic experience outsider status or subordinate position leads to increased striatal dopamine activity and thereby risk, has been criticized. aims this paper are improve definition integrate with neurodevelopmental hypothesis. Marmot advanced idea low is pathogenic in it associated a lack participation autonomy. Given similarity position, we re-define as status. From new perspective also likely pre-schizophrenic impairments (of origin not) they contribute effect may be enhanced by repeated exposure humiliation, but few studies have measured variable. Since most individuals exposed do not develop propose risk factor increases disorder presence poor homeostatic control neurons midbrain dorsal striatum. This consistent healthy subjects report negative association between socio-economic D2/D3 receptor availability In version combination status, humiliation striatum an schizophrenia.

Язык: Английский

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Advances in the understanding of the pathophysiology of schizophrenia and bipolar disorder through induced pluripotent stem cell models

Journal of Psychiatry and Neuroscience, Год журнала: 2024, Номер 49(2), С. E109 - E125

Опубликована: Март 15, 2024

The pathophysiology of schizophrenia and bipolar disorder involves a complex interaction between genetic environmental factors that begins in the early stages neurodevelopment. Recent advancements field induced pluripotent stem cells (iPSCs) offer promising tool for understanding neurobiological alterations involved these disorders and, potentially, developing new treatment options. In this review, we summarize results iPSC-based research on disorder, showing disturbances neurodevelopmental processes, imbalance glutamatergic-GABAergic transmission neuromorphological alterations. limitations reviewed literature are also highlighted, particularly methodological heterogeneity studies, limited number studies iPSC models both diseases simultaneously, lack in-depth clinical characterization included samples. Further needed to advance knowledge common disease-specific pathophysiological features promote development

Язык: Английский

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Parkinsonism, Psychomotor Slowing, Negative and Depressive Symptoms in Schizophrenia Spectrum and Mood Disorders: Exploring Their Intricate Nexus Using a Network Analytic Approach

Schizophrenia Bulletin, Год журнала: 2024, Номер unknown

Опубликована: Апрель 26, 2024

Parkinsonism, psychomotor slowing, negative and depressive symptoms show evident phenomenological similarities across different mental disorders. However, the extent to which they interact with each other is currently unclear. Here, we hypothesized that parkinsonism an independent motor abnormality showing limited associations in schizophrenia spectrum (SSD), mood disorders (MOD).

Язык: Английский

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White matter modifications of corpus callosum in bipolar disorder: A DTI tractography review

Journal of Affective Disorders, Год журнала: 2023, Номер 338, С. 220 - 227

Опубликована: Июнь 9, 2023

Язык: Английский

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Maternal allergic inflammation in rats impacts the offspring perinatal neuroimmune milieu and the development of social play, locomotor behavior, and cognitive flexibility

Brain Behavior and Immunity, Год журнала: 2021, Номер 95, С. 269 - 286

Опубликована: Март 30, 2021

Язык: Английский

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