Journal of Neuroimmunology, Год журнала: 2024, Номер 390, С. 578341 - 578341
Опубликована: Апрель 8, 2024
Язык: Английский
Neuroscience & Biobehavioral Reviews, Год журнала: 2023, Номер 152, С. 105319 - 105319
Опубликована: Июль 14, 2023
Social play behaviour is a highly energetic and rewarding activity that of great importance for the development brain behaviour. abundant during juvenile early adolescent phases life, it occurs in most mammalian species, as well certain birds reptiles. To date, majority research into neural mechanisms social has been performed male rats. In present review we summarize studies on neurobiology rats, including work pharmacological genetic models autism spectrum disorders, life manipulations environmental factors influence We describe several recent developments expand field, highlight outstanding questions may guide future studies.
Язык: Английский
Процитировано
35
Neuronal Signaling, Год журнала: 2023, Номер 7(4)
Опубликована: Окт. 27, 2023
Abstract Emotion dysregulation (ED) describes a difficulty with the modulation of which emotions are felt, as well when and how these experienced or expressed. It is focal overarching symptom in many severe prevalent neuropsychiatric diseases, including bipolar disorders (BD), attention deficit/hyperactivity disorder (ADHD), borderline personality (BPD). In all disorders, ED can manifest through symptoms depression, anxiety, affective lability. Considering symptomatic similarities between BD, ADHD, BPD, transdiagnostic approach promising lens investigation. Mounting evidence supports role peripheral inflammatory markers stress multifactorial aetiology physiopathology BPD. Of note, neural circuits that regulate appear particularly vulnerable to insults inflammation, impact neuroimmune milieu central nervous system. Thus far, few studies have examined link inflammation To our knowledge, no specific work has provided critical comparison results from disorders. fill this gap literature, we review known associations mechanisms linking general, clinically, BD. Our narrative begins an examination routes followed by discussion disorder-specific accounting for methodological limitations relevant confounding factors. Finally, critically discuss both correspondences discrepancies comment on potential vulnerability therapeutic interventions.
Язык: Английский
Процитировано
26
动物学研究, Год журнала: 2021, Номер 42(6), С. 800 - 823
Опубликована: Янв. 1, 2021
Autism spectrum disorder (ASD) is typically characterized by common deficits in social skills and repetitive/stereotyped behaviors. It widely accepted that genetic environmental factors solely or combination cause ASD. However, the underlying pathogenic mechanism unclear due to its highly heterogeneous nature. To better understand pathogenesis of ASD, various animal models have been generated, which can be generally divided into genetic, environment-induced, idiopathic models. In this review, we summarize animals used for ASD study then discuss applications, clinical insights, as well challenges prospects current
Язык: Английский
Процитировано
47
Current topics in behavioral neurosciences, Год журнала: 2022, Номер unknown, С. 165 - 206
Опубликована: Янв. 1, 2022
Язык: Английский
Процитировано
28
Neuron, Год журнала: 2023, Номер 111(21), С. 3435 - 3449.e8
Опубликована: Ноя. 1, 2023
Interleukin-4 (IL-4) is a type 2 cytokine with pleiotropic functions in adaptive immunity, allergies, and cognitive processes. Here, we show that low levels of IL-4 the early postnatal stage delineate critical period which microglia extensively prune cerebellar neurons. Elevating this via peripheral injection, or using mouse model allergic asthma, leads to defective pruning, permanent increase granule cells, circuit alterations. These animals also hyperkinetic impulsive-like phenotype, reminiscent attention-deficit hyperactivity disorder (ADHD). alterations are blocked Il4rαfl/fl::Cx3cr1-CreER mice, deficient receptor signaling microglia. findings demonstrate previously unknown role for during neuroimmune maturation provide first putative mechanism comorbidity between disease ADHD observed humans.
Язык: Английский
Процитировано
15
Biological Psychiatry, Год журнала: 2022, Номер 92(6), С. 460 - 469
Опубликована: Апрель 22, 2022
Язык: Английский
Процитировано
20
Biological Psychiatry Global Open Science, Год журнала: 2023, Номер 4(1), С. 39 - 50
Опубликована: Окт. 11, 2023
Maternal inflammation can result from immune dysregulation and metabolic perturbations during pregnancy. Whether conditions associated with pregnancy increase the likelihood of autism spectrum (ASD) or other neurodevelopmental disorders (DD) is not well understood. We conducted a case-control study among children born in California 2011 – 2016 to investigate maternal immune-mediated cardiometabolic risk ASD (N=311) DD (N=1291) compared general population (GP, N=967). Data on covariates were retrieved electronic health records. genetic data used assess causal relationship. Using multivariable logistic regression, mothers asthma more likely deliver infants diagnosed (Odds Ratio (OR)=1.62, 95% Confidence Interval (CI): [1.15–2.29]) (OR=1.30, CI: [1.02–1.64]). obesity was (OR=1.51, [1.07–2.13]). The combination extreme demonstrated greatest odds (OR=16.9, [5.13–55.71]). These increased observed females only. Polygenic scores (PRS) for obesity, asthma, their showed no association ASD. Mendelian randomization did support relationship Inflammatory are children. Risks do appear be due shared risk, rather inflammatory may share non-genetic factors disorders. Children whose have both benefit earlier screening intervention.
Язык: Английский
Процитировано
13
Brain Behavior and Immunity, Год журнала: 2023, Номер 116, С. 218 - 228
Опубликована: Дек. 8, 2023
Asthma is a highly heterogeneous inflammatory disease that can have significant effect on both the respiratory system and central nervous system. Population based studies animal models found asthma to be comorbid with number of neurological conditions, including depression, anxiety, neurodevelopmental disorders. In addition, maternal during pregnancy has been associated disorders in offspring, such as autism spectrum attention deficit hyperactivity disorder. this article, we review most current epidemiological identify links it relates individuals suffer from impacts may offspring neurodevelopment. We also discuss relevant investigating these links, address gaps knowledge, explore potential future directions field.
Язык: Английский
Процитировано
12
Cerebral Cortex, Год журнала: 2022, Номер 33(2), С. 316 - 329
Опубликована: Фев. 4, 2022
The male preponderance in autism spectrum disorder (ASD) led to the hypothesis that aspects of female biology are protective against ASD. Females with ASD (ASD-F) report more compensatory behaviors (i.e. "camouflaging") overcome ASD-related social differences, which may be a mechanism protection. No studies have examined sex-related brain pathways supporting camouflaging ASD-F, despite its potential inform mechanisms underlying sex bias. We used functional connectivity (FC) investigate "sex-atypical" and "sex-typical" FC patterns linked adults multimodal coherence findings via structural connectometry. Exploratory associations cognitive/emotional functioning adaptive nature patterns. found (i) hypothalamus precuneus (ii) right anterior cingulate parahippocampus. Higher hypothalamic limbic reward cluster also correlated better cognitive control/emotion recognition. Structural connectometry validated results consistent pathways/effect implicated ASD-F. In summary, "male-typical" "female-typical" support ASD-F circuits reward, emotion, memory retrieval. "Sex-atypical" fetal steroidogenic/neuroinflammatory hypotheses. However, genetics/biology contribute camouflaging.
Язык: Английский
Процитировано
18
Journal of Neurochemistry, Год журнала: 2024, Номер 169(1)
Опубликована: Авг. 25, 2024
Maternal immune activation (MIA) induces a variety of behavioral and brain abnormalities in offspring rodent models, compatible with neurodevelopmental disorders, such as schizophrenia or autism. However, it remains controversial whether MIA impairs reversal learning, basic expression cognitive flexibility that seems to be altered schizophrenia. In the present study, was induced by administration single dose polyriboinosinic-polyribocytidylic acid (Poly (I:C) (5 mg/kg i.p.)) saline mouse pregnant dams gestational day (GD) 9.5. Immune monitored through changes weight temperature. The were evaluated when they reached adulthood (8 weeks) using touchscreen-based system investigate effects Poly on discrimination learning performance. After an initial pre-training, mice trained discriminate between two different stimuli, which only one rewarded (acquisition phase). When correct response above 80% values for consecutive days, images reversed (reversal phase) assess adaptation capacity changing environment. treatment did not interfere process but deficits compared control animals. Thus, accuracy phase lower, animals required more sessions complete it, suggesting impairments flexibility. This study advances knowledge how affects behavior, especially domains are impaired findings support validity (I:C)-based model tool develop pharmacological treatments targeting associated disorders.
Язык: Английский
Процитировано
4