Alzheimer’s disease as a synaptopathy: Evidence for dysfunction of synapses during disease progression

Frontiers in Synaptic Neuroscience, Год журнала: 2023, Номер 15

Опубликована: Март 9, 2023

The synapse has consistently been considered a vulnerable and critical target within Alzheimer’s disease, loss is, to date, one of the main biological correlates cognitive decline disease. This occurs prior neuronal with ample evidence that synaptic dysfunction precedes this, in support idea failure is crucial stage disease pathogenesis. two pathological hallmarks abnormal aggregates amyloid or tau proteins, have had demonstrable effects on physiology animal cellular models There also growing these proteins may synergistic effect neurophysiological dysfunction. Here, we review some findings alterations what know from models. First, briefly summarize human suggest synapses are altered, including how this relates network activity. Subsequently, considered, highlighting mouse pathology role play dysfunction, either isolation examining pathologies interact specifically focuses function observed models, typically measured using electrophysiology calcium imaging. Following loss, it would be impossible imagine not alter oscillatory activity brain. Therefore, discusses underpin aberrant patterns seen patients. Finally, an overview key directions considerations field covered. includes current therapeutics targeted at but methods modulate rescue patterns. Other important future avenues note include non-neuronal cell types such as astrocytes microglia, mechanisms independent will certainly continue for foreseeable future.

Язык: Английский

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Physical exercise for brain plasticity promotion an overview of the underlying oscillatory mechanism

Frontiers in Neuroscience, Год журнала: 2024, Номер 18

Опубликована: Авг. 8, 2024

The global recognition of the importance physical exercise (PE) for human health has resulted in increased research on its effects cortical activity. Neural oscillations, which are prominent features brain activity, serve as crucial indicators studying PE function. Existing studies support idea that modifies various types neural oscillations. While EEG-related literature science exists, a comprehensive review specifically healthy populations not yet been conducted. Given demonstrated influence plasticity, particularly oscillatory it is imperative to consolidate this phenomenon. Therefore, aims summarize numerous neuromodulatory mechanisms over past decade, covering (1) resistance and aerobic training via oscillations; (2) how mind-body affects activity cognitive functioning; (3) age-Related neurodegenerative disease rehabilitation oscillation mechanisms; (4) conclusion future direction. In conclusion, effect multifaceted process, seeks comprehensively examine existing studies' understanding regulates brain, providing more scientific theoretical foundation development personalized programs further research.

Язык: Английский

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Interictal epileptiform discharges affect memory in an Alzheimer’s disease mouse model

Proceedings of the National Academy of Sciences, Год журнала: 2023, Номер 120(34)

Опубликована: Авг. 17, 2023

Interictal epileptiform discharges (IEDs) are transient abnormal electrophysiological events commonly observed in epilepsy patients but also present other neurological diseases, such as Alzheimer's disease (AD). Understanding the role IEDs have on hippocampal circuit is important for our understanding of cognitive deficits seen and AD. We characterize compare human from microwire recording with those AD transgenic mice implanted multilayer silicon probes. Both local field potential features firing patterns pyramidal cells interneurons were similar mouse human. found that emerged CA3-1 circuits, they recruited silenced interneurons, followed by post-IED suppression. suppressed incidence altered properties physiological sharp-wave ripples, their properties, interfered replay place sequences a maze. In addition, inversely correlated daily memory performance. Together, work implies may common epilepsy-independent phenomenon neurodegenerative diseases perturbs hippocampal-cortical communication interferes memory.

Язык: Английский

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Impairment of entorhinal cortex network activity in Alzheimer’s disease

Frontiers in Aging Neuroscience, Год журнала: 2024, Номер 16

Опубликована: Май 31, 2024

The entorhinal cortex (EC) stands out as a critical brain region affected in the early phases of Alzheimer’s disease (AD), with some disease’s pathological processes originating from this area, making it one most crucial regions AD. Recent research highlights disruptions brain’s network activity, characterized by heightened excitability and irregular oscillations, may contribute to cognitive impairment. These are proposed not only potential therapeutic targets but also biomarkers for In paper, we will begin review anatomy function EC, highlighting its selective vulnerability Subsequently, discuss disruption EC exploring changes neuronal oscillations during AD hypothesize that, considering advancements neuromodulation techniques, addressing disturbances activity could offer fresh insights both diagnosis treatment

Язык: Английский

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Phase-dependent closed-loop deep brain stimulation of the fornix provides bidirectional manipulation of hippocampal theta oscillations

Brain stimulation, Год журнала: 2025, Номер unknown

Опубликована: Апрель 1, 2025

Язык: Английский

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Potential Roles of Nr4a3-Mediated Inflammation in Immunological and Neurological Diseases

Molecular Neurobiology, Год журнала: 2024, Номер 61(8), С. 5958 - 5973

Опубликована: Янв. 23, 2024

Язык: Английский

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Transcranial magneto-acoustic stimulation improves spatial memory and modulates hippocampal neural oscillations in a mouse model of Alzheimer's disease

Frontiers in Neuroscience, Год журнала: 2024, Номер 18

Опубликована: Фев. 7, 2024

Introduction In our study, we applied transcranial magneto-acoustic stimulation (TMAS), a technique based on focused ultrasound within static magnetic field, in the APP/PS1 mouse model of Alzheimer's disease (AD) to explore feasibility TMAS improving AD related spatial memory deficits and abnormal neural oscillations. Methods The mice treated with once daily for 21 days. We recorded local field potential signals hippocampal CA1 region after treatment in-vivo electrophysiology evaluated rehabilitative effect sharp-wave ripple (SWR), gamma oscillations during SWRs, phase-amplitude coupling (PAC). function was examined by Morris water maze (MWM) task. Results found that improved performance MWM cognitive functions compared group. Furthermore, results implied alleviated abnormalities increased slow power promoted theta-slow coupling. These findings suggest could have positive influence through modulation Discussion This work emphasizes serve as non-invasive method rehabilitation promote application more neurological brain aging diseases future.

Язык: Английский

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Theta–gamma coupling as a ubiquitous brain mechanism: implications for memory, attention, dreaming, imagination, and consciousness

Current Opinion in Behavioral Sciences, Год журнала: 2024, Номер 59, С. 101433 - 101433

Опубликована: Июль 4, 2024

Brain rhythms are known to play a relevant role in many cognitive functions. In particular, coupling between theta and gamma oscillations was first observed the hippocampus, where it is assumed implement code for organizing multiple items memory. More recent advances, however, demonstrate that this mechanism ubiquitously present brain plays not only working memory but also episodic semantic memory, attention, emotion, dreaming, imagination. Furthermore, altered mental states neurological disorders show profound alterations theta–gamma code. review, which summarizes most experimental theoretical evidence, we suggest substantial capacity integrate information characteristic of entrainment fundamental implementing conscious processes.

Язык: Английский

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Olfactory bulb stimulation mitigates Alzheimer's‐like disease progression

CNS Neuroscience & Therapeutics, Год журнала: 2024, Номер 30(10)

Опубликована: Окт. 1, 2024

Deep brain stimulation (DBS) has demonstrated potential in mitigating Alzheimer's disease (AD). However, the invasive nature of DBS presents challenges for its application. The olfactory bulb (OB), showing early AD-related changes and extensive connections with memory regions, offers an attractive entry point intervention, potentially restoring normal activity deteriorating circuits.

Язык: Английский

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A functional MRI and magnetoencephalography study of the cognitive modulatory effect of transcranial direct current stimulation in early Alzheimer’s disease

medRxiv (Cold Spring Harbor Laboratory), Год журнала: 2025, Номер unknown

Опубликована: Апрель 4, 2025

Abstract Anodal transcranial direct current stimulation(tDCS) is known to improve cognition in patients with mild cognitive impairment (MCI) and Alzheimer’s disease(mild AD). We aimed examine the brain functional alterations accompanying improvement performance following anodal tDCS at left dorsolateral prefrontal cortex(DLPFC) a sample of early AD (N=40; MCI, n= 19 & AD, n=21) using magnetic resonance imaging (fMRI) magnetoencephalography(MEG). The showed significant improvements episodic memory, learning, delayed recall intervention. Significant (p-FDR < 0.05) reduction seed (left middle frontal gyrus, lMFG)-to-voxel resting state connectivity(rsFC) precuneus posterior cingulate gyrus(PCC) was noted intervention, while task-based fMRI(tbfMRI) analysis revealed increases blood oxygen level-dependent(BOLD) activations PCC right MFG(rMFG) during memory encoding retrieval tasks respectively. Furthermore, decrease MEG(rsMEG) gamma power occipital cortex an increase phase (theta) amplitude (gamma) coupling entorhinal were observed post-tDCS. findings this comprehensive study fMRI MEG, as well fMRI, provide mechanistic insights regarding that underlie modulatory effects AD.

Язык: Английский

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