Contribution of membrane-associated oscillators to biological timing at different timescales

Frontiers in Physiology, Год журнала: 2024, Номер 14

Опубликована: Янв. 9, 2024

Environmental rhythms such as the daily light-dark cycle selected for endogenous clocks. These clocks predict regular environmental changes and provide basis well-timed adaptive homeostasis in physiology behavior of organisms. Endogenous are oscillators that based on positive feedforward negative feedback loops. They generate stable even under constant conditions. Since weak interactions between allow autonomous synchronization, coupling/synchronization provides self-organized physiological timing. Amongst most thoroughly researched circadian clock neurons mammals insects. comprise nuclear clockworks transcriptional/translational loops (TTFL) ∼24 h gene expression entrained to day-night cycle. It is generally assumed this TTFL clockwork drives all oscillations within cells, being any rhythm Instead current gene-based hierarchical model we here a systems view We suggest coupled system posttranslational loop (PTFL) oscillators/clocks run at multiple timescales governs adaptive, dynamic behavior. focus mammalian insect timescales. neuronal plasma membrane-associated signalosomes constitute specific PTFL localized but interlinked membrane potential intracellular messengers with frequencies. In each neuron multiscale form temporally structured oscillatory network common complex frequency-band comprising superimposed oscillations. Coupling oscillator/clock next level complexity an network. This systemic molecular cellular suggested cycles through homeostatic setpoints characteristic hallmark. propose mechanisms plasticity maintain stability these setpoints, whereas Hebbian enables switching via coupling factors, like biogenic amines and/or neuropeptides. reprogram new frequency, setpoint. Our novel hypothesis up experimental challenge.

Язык: Английский

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Systemic neurophysiological entrainment to behaviorally relevant rhythmic stimuli

Physiological Reports, Год журнала: 2024, Номер 12(19)

Опубликована: Окт. 1, 2024

Physiological oscillations, such as those involved in brain activity, heartbeat, and respiration, display inherent rhythmicity across various timescales. However, adaptive behavior arises from the interaction between these intrinsic rhythms external environmental cues. In this study, we used multimodal neurophysiological recordings, simultaneously capturing signals central autonomic nervous systems (CNS ANS), to explore dynamics of body response rhythmic auditory stimulation three conditions: baseline (no stimulation), passive processing, active processing (discrimination task). Our findings demonstrate that engagement with synchronizes both CNS ANS rhythm, unlike conditions, evidenced by power spectral density (PSD) coherence analyses. Importantly, phase angle analysis revealed a consistent alignment participants their physiological oscillatory phases at stimulus or onsets. This was associated reaction times, suggesting certain oscillations are spontaneously prioritized individuals due role sensorimotor behavior. These results highlight intricate interplay optimizing responses demands, potential mechanism embodied predictive processing.

Язык: Английский

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Cardio-respiratory interactions in interoceptive perception: The role of heartbeat-modulated cortical oscillations

bioRxiv (Cold Spring Harbor Laboratory), Год журнала: 2025, Номер unknown

Опубликована: Апрель 19, 2025

Abstract The cardiovascular and respiratory systems are anatomically functionally integrated within the cardio-respiratory system. This close connection suggests that breathing continuously shapes cardiac interoceptive perception. Previously, we demonstrated interactions in heartbeat-evoked potential, a neural marker of cortical processing signals. Specifically, observed enhanced late potential positivity greater accuracy during exhalation compared to inhalation participants engaged tasks. Here, extended these findings time-frequency domain by reanalysing our previous dataset. We investigated heartbeat-modulated oscillations, examining power, inter-trial coherence, functional connectivity across cycle at rest, task (heartbeat counting), an exteroceptive control (cardiac-tone counting). Results revealed heartbeat counting task, heartbeat-related increased inhalation, particularly alpha theta frequency bands. These effects were primarily localized right fronto-centro-parietal electrodes. Furthermore, identified interactive relationships between oscillations band predicted accuracy. independent physiology absent task. proposed model framework predictive coding, suggesting occur multiple levels hierarchy: peripheral, brainstem, cortical. Our interpretation highlights role alpha-band modulations enhancing precision-weighting prediction errors, thereby facilitating attentional allocation signals suppression task-irrelevant distractors, exhalation.

Язык: Английский

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Common threads: Altered interoceptive processes as transdiagnostic mechanisms across affective and anxiety disorders

Journal of Affective Disorders, Год журнала: 2024, Номер unknown

Опубликована: Сен. 1, 2024

Язык: Английский

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Coactivation of Autonomic and Central Nervous Systems During Processing of Socially Relevant Information in Autism Spectrum Disorder: A Systematic Review

Neuropsychology Review, Год журнала: 2023, Номер 34(1), С. 214 - 231

Опубликована: Фев. 27, 2023

Abstract Body-brain interaction provides a novel approach to understand neurodevelopmental conditions such as autism spectrum disorder (ASD). In this systematic review, we analyse the empirical evidence regarding coexisting differences in autonomic (ANS) and central nervous system (CNS) responses social stimuli between individuals with ASD typically developing individuals. Moreover, review of deviations body-brain during processing socially relevant information ASD. We conducted literature searches PubMed, Medline, PsychInfo, PsychArticles, Cinahl databases (until 12.1.2022). Studies were included if compared individuals, study design information, ANS CNS activity measured simultaneously. Out 1892 studies identified based on titles abstracts, only six fulfilled eligibility criteria be synthesis. The quality these was assessed using assessment checklist. results indicated that demonstrate atypicalities signalling which, however, are context dependent. There also indications for altered contribution ANS-CNS However, findings must considered several limitations, small sample sizes high variability (neuro)physiological measures. Indeed, methodological choices varied considerably, calling need unified guidelines improve interpretability results. summarize current experimentally supported understanding role Furthermore, propose developments future incremental knowledge building across involving

Язык: Английский

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Cardiorespiratory dynamics during respiratory maneuver in athletes

Frontiers in Network Physiology, Год журнала: 2023, Номер 3

Опубликована: Окт. 30, 2023

Introduction: The modern practice of sports medicine and medical rehabilitation requires the search for subtle criteria development conditions recovery body after diseases, which would have a prognostic value prevention negative effects training tools, also testify to course mechanisms counteracting pathogenetic processes in body. purpose this study was determine informative directions cardiorespiratory system parameters dynamics during performing maneuver with change breathing rate, may indicate functional state violation. Methods: results 183 healthy men aged 21.2 ± 2.3 years who regularly engaged various were analyzed. procedure studying included conducting combined measurements indicators activity respiratory cardiovascular systems sitting position using spiroarteriocardiograph device. duration 6 min involved sequential registration three rate (spontaneous breathing, at 0.1 Hz 0.25 Hz). Results: Performing comparison spontaneous leads multidirectional significant changes heart variability indicators-TP (ms2), LF LFHF (ms2/ms2); blood pressure indicators-TPDBP (mmHg2), LFSBP LFDBP HFSBP (mmHg2); volume respiration - LFR, (L×min-1)2; HFR, LFHFR, (L×min-1)2/(L×min-1)2; arterial baroreflex sensitivity BRLF (ms×mmHg-1), BRHF (ms×mmHg-1). Differences systemic hemodynamics synchronization informative. Conclusion: According study, it is shown that there are parameters, analysis increments made possible dynamics, their absolute values limits regarding occurrence interactions dysregulation.

Язык: Английский

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Cardiorespiratory rhythm-contingent trace eyeblink conditioning in elderly adults

Journal of Neurophysiology, Год журнала: 2024, Номер 131(5), С. 797 - 806

Опубликована: Март 27, 2024

Learning outcome is modified by the degree to which subject responds and pays attention specific stimuli. Our recent research suggests that presenting stimuli in contingency with a phase of cardiorespiratory rhythm might expedite learning. Specifically, expiration-diastole (EXP-DIA) beneficial for learning trace eyeblink conditioning (TEBC) compared inspiration-systole (INS-SYS) healthy young adults. The aim this study was investigate whether same holds true elderly adults (

Язык: Английский

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Cardiorespiratory synchronization under the influence of strength endurance training

Physical rehabilitation and recreational health technologies, Год журнала: 2024, Номер 9(1), С. 25 - 35

Опубликована: Янв. 30, 2024

Purpose: to determine changes in the parameters of cardiorespiratory relationships during maneuver with a change breathing rate after 4-month cycle training aimed at development strength endurance. Material & Methods: results spiroarteriocardiorhythmographic study 22 healthy men aged 20.7±2.3 years, who for 4 months 2 times week 90 minutes, were analyzed (a total 30 classes held) engaged The indicators heart (min–1), respiratory cardiac output (dm3×min–1), minute lung ventilation (L×min–1) and their derivatives – Hildebrandt index (HR/RR) volume synchronization (CO/V), which obtained spontaneous respiration controlled 0.1 Hz 0.25 Hz. Results: it was shown that endurance led probable decrease from 71.4 (63.9; 77.5) 64.3 (60.8; 68.3), p=0.002, 14.1 (12, 7; 16.8) 13.8 (10.7; 15.3), p= 0.020 8.19 (6.24; 8.86) 6.40 (3.73; 7.74) ), p=0.004 breathing, as well significant increase volumetric index. (dm3×L–1) 0.597 (0.490; 0.832) 0.725 (0.564; 1.148), p=0.008, 0.327 (0.382; 0.529) 0.532 (0.441; 0.723), p=0.012 0,245 (0,339; 0,455) 0,481 (0,373; 0,616), р=0,003 against background 0,1 11.14 (10.43; 12.49) 10.18 (9.54; 11.00), p=0.001, 5.33 (4.68; 5.85) 4.46 (4.13; 4, 78), p=0.000. Conclusions: an economization cardiovascular systems function response sympathoadrenal activation hyperventilation.

Язык: Английский

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Common Threads: Altered Interoceptive Processes as Transdiagnostic Mechanisms Across Affective and Anxiety disorders

Опубликована: Июль 28, 2024

There is growing attention towards atypical brain-body interactions and interoceptive processes their potential role in psychiatric conditions, including affective anxiety disorders. This paper aims to synthesize recent developments this field. We present emerging explanatory models focus on coupling modulations of the underlying neurocircuitry that support concept a continuum Grounded theoretical frameworks like peripheral theories emotion predictive processing, we propose altered might represent transdiagnostic mechanisms confer common vulnerability traits across multiple A deeper understanding interplay between bodily states neural processing essential for holistic conceptualization mental

Язык: Английский

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Neural activity is modulated by spontaneous and volitionally controlled breathing

bioRxiv (Cold Spring Harbor Laboratory), Год журнала: 2023, Номер unknown

Опубликована: Сен. 1, 2023

Abstract Recent studies have provided evidence regarding respiration-brain coupling, but how continuously varying dynamics of breathing modulate neural activity is not known. We examined whether the state differs between spontaneous and volitionally controlled across phases breathing, inspiration expiration. Magnetoencephalography with a respiratory belt was used to record cortical oscillatory during spontaneous, deep, square (n=33). Alpha power suppressed increased expiration (p<0.01) indicating dynamically fluctuating states cycle. Compared alpha deep (p<0.01). also observed steeper aperiodic slope broadband shift in spectrum comparison suggesting that spectral characteristics are modulated by rate, depth, pattern breathing. Altogether, we demonstrate techniques

Язык: Английский

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