Attention to cardiac sensations enhances the heartbeat-evoked potential during exhalation

iScience, Год журнала: 2024, Номер 27(4), С. 109586 - 109586

Опубликована: Март 27, 2024

Respiration and cardiac activity intricately interact through complex physiological mechanisms. The heartbeat-evoked potential (HEP) is an EEG fluctuation reflecting the cortical processing of signals. We recently found higher HEP amplitude during exhalation than inhalation a task involving attention to sensations. This may have been due reduced perception heightened attentional To investigate relationships between HEP, attention, respiration, we introduced experimental setup that included tasks related respiratory interoceptive exteroceptive attention. Results revealed increases over fronto-central electrodes. When phases were taken into account, primarily driven by heartbeats recorded exhalation, specifically task, while had minimal impact. These findings emphasize role respiration in could implications for interventions fine-tune interoception.

Язык: Английский

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Respiration shapes response speed and accuracy with a systematic time lag

Proceedings of the Royal Society B Biological Sciences, Год журнала: 2025, Номер 292(2044)

Опубликована: Апрель 1, 2025

Sensory–cognitive functions are intertwined with physiological processes such as the heart beat or respiration. For example, we tend to align our respiratory cycle expected events actions. This happens during sports but also in computer-based tasks and systematically structures phase around relevant events. However, studies show that trial-by-trial variations shape brain activity speed accuracy of individual responses. We both phenomena—the alignment respiration explanatory power on behaviour—co-exist. In fact, average an relative experimental trials trial-to-trial hold significant predictive behavioural performance, particular for reaction times. co-modulation behaviour emerges regardless whether generally breathes faster slower is strongest about 2 s prior participant’s The persistence these effects across 12 datasets 277 participants performing sensory–cognitive confirms robustness results, suggests a profound time-lagged influence structured sensory–motor

Язык: Английский

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Respiratory sinus arrhythmia (RSA), vagal tone and biobehavioral integration: Beyond parasympathetic function

Biological Psychology, Год журнала: 2023, Номер 186, С. 108739 - 108739

Опубликована: Дек. 25, 2023

Linchpin to the entire area of psychophysiological research and discussion vagus is respiratory cardiovascular phenomenon known as sinus arrhythmia (RSA; often synonymous with high-frequency heart-rate variability when it specifically linked frequency), i.e. rhythmic fluctuations in heart rate synchronized inspiration expiration. This article aims 1) clarify concepts, terms measures commonly employed during last half century scientific literature, which relate vagal function psychological processes general aspects health; 2) expand upon an earlier theoretical model, emphasizing importance RSA well beyond current focus parasympathetic mechanisms. A close examination its relations may dispel certain held beliefs about associations between functioning, nervous system (for nerve plays a major role), offer fresh perspectives likely functions adaptive significance RSA, RSA's relationship control. neither invariably reliable index cardiac tone nor central outflow heart. The model here presented posits that represents evolutionarily entrenched, significantly contributes meeting continuously changing metabolic, energy behavioral demands.

Язык: Английский

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Signal processing in the vagus nerve: Hypotheses based on new genetic and anatomical evidence

Biological Psychology, Год журнала: 2023, Номер 182, С. 108626 - 108626

Опубликована: Июль 6, 2023

Each organism must regulate its internal state in a metabolically efficient way as it interacts space and time with an ever-changing only partly predictable world. Success this endeavor is largely determined by the ongoing communication between brain body, vagus nerve crucial structure that dialogue. In review, we introduce novel hypothesis afferent engaged signal processing rather than just relay. New genetic structural evidence of vagal fiber anatomy motivates two hypotheses: (1) sensory signals informing on physiological body compute both spatial temporal viscerosensory features they ascend nerve, following patterns found other architectures, such visual olfactory systems; (2) ascending descending modulate one another, calling into question strict segregation motor signals, respectively. Finally, discuss several implications our hypotheses for understanding role predictive energy regulation (i.e., allostasis) well metabolic memory disorders prediction (e.g., mood disorders).

Язык: Английский

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The timing of sleep spindles is modulated by the respiratory cycle in humans

Clinical Neurophysiology, Год журнала: 2024, Номер 166, С. 252 - 261

Опубликована: Июль 9, 2024

Coupling of sleep spindles with cortical slow waves and hippocampus sharp-waves ripples is crucial for sleep-related memory consolidation. Recent literature evidenced that nasal respiration modulates neural activity in large-scale brain networks. In rodents, this respiratory drive strongly varies according to vigilance states. Whether oscillations are also respiration-modulated humans remains open. work, we investigated the influence breathing on during non-rapid-eye-movement humans. Full night polysomnography twenty healthy participants were analysed. Spindles automatically detected N2 N3 stages. Spindle-related sigma power as well spindle wave events analysed phase. We found a significant coupling between both fast cycle, enhanced occurrence probability middle part expiration A different was observed negative peaks which rather distributed around two phase transitions. Our findings suggest cycle influences dynamics sleep. This may enable synchronize other facilitate information transfer

Язык: Английский

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Dynamic mechanisms that couple the brain and breathing to the external environment

Communications Biology, Год журнала: 2024, Номер 7(1)

Опубликована: Авг. 3, 2024

Brain and breathing activities are closely related. However, the exact neurophysiological mechanisms that couple brain to stimuli in external environment not yet agreed upon. Our data support synchronization dynamic attunement two key local activity periodic stimuli. First, we review existing literature, which provides strong evidence for of terms coherence, cross-frequency coupling phase-based entrainment. Second, using EEG data, show both lungs localized at Cz channel attune temporal structure their power spectra auditory inputs. We highlight role playing a coordinating tripartite alignment activity, input dynamics across longer timescales like minutes. Overall, this perspective sheds light on potential brain-breathing its environment.

Язык: Английский

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Cortical and subcortical mapping of the allostatic-interoceptive system in the human brain: replication and extension with 7 Tesla fMRI

bioRxiv (Cold Spring Harbor Laboratory), Год журнала: 2023, Номер unknown

Опубликована: Июль 24, 2023

Abstract The brain continuously anticipates the energetic needs of body and prepares to meet those before they arise, called allostasis. In support allostasis, continually models sensory state body, interoception. We replicated extended a large-scale system supporting allostasis interoception in human using ultra-high precision 7 Tesla functional magnetic resonance imaging (fMRI) ( N = 90), improving subgenual pregenual anterior cingulate topography combined with extensive brainstem nuclei mapping. observed over 90% anatomical connections published tract-tracing studies non-human animals. also included regions dense intrinsic connectivity broadly throughout system, some which were identified previously as part backbone neural communication across brain. These results strengthen previous evidence for whole-brain modeling regulation internal milieu body.

Язык: Английский

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Pressure Pulsatility Links Cardio-Respiratory and Brain Rhythmicity

Journal of Integrative Neuroscience, Год журнала: 2023, Номер 22(6)

Опубликована: Окт. 23, 2023

This article presents evidence indicating that intracranial pressure (ICP) pulsatility, associated with the heartbeat and breathing, is not just a source of mechanical artefact in electrical recordings, but “sensed” plays role brain’s information processing. Patch-clamp recording pressure-activated channels, detection Piezo2-protein channel expression brain neurons, suggest these channels provide neurons an intrinsic resonance to ICP which acts synchronize remote neural networks. Direct measurements human patients indicate breathing rhythms generate forces tens millinewtons, exceeding by orders magnitude localized shown atomic force microscopy optical tweezers activate Piezo isolated neocortical hippocampal neurons. Additionally, many touch proprioceptors, are also transduced show spiking phase-locked heartbeat- breathing-induced extracranial pulsations. Finally, based on observation low-frequency oscillations modulate phase amplitude high-frequency oscillations, body proposed form single hierarchical system basic frequency scaling factor for all other oscillations. Together, results support idea pulsatility may be elemental modulating rhythmicity.

Язык: Английский

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Detection of respiratory frequency rhythm in human alpha phase shifts: topographic distributions in wake and drowsy states

Frontiers in Physiology, Год журнала: 2025, Номер 15

Опубликована: Янв. 6, 2025

The relationship between brain activity and respiration is recently attracting increasing attention, despite being studied for a long time. Respiratory modulation was evidenced in both single-cell field potentials. Among EEG intracranial measurements, the effect of prevailingly on amplitude/power all frequency bands. Since phases oscillations received less we applied our previously published carrier (CF) mathematical model human alpha group 10 young healthy participants wake drowsy states, using 14-channel average reference montage. approach allows more precise calculation CF phase shifts (CFPS) than any individual Fourier component, by 2-s moving window, validated new method studied, first time, temporal waveforms CFPS(t) their oscillatory content through FFT (CFPS(t)). Although not appearing equally channel pairs every subject, clear peak respiratory region, 0.21-0.26 Hz, observed (max at 0.22 Hz). When five with most prominent averaged amplitudes Hz were plotted topographic distributions changed significantly-from longitudinal, connecting frontal posterior channels state to topographically split two separate regions-frontal state. In addition, state, 0.22-Hz decreased pairs, while statistically significant reduction obtained 20/91 (22%) pairs. These results potentially evidence, shifts, as well impact wakeful consciousness oscillations.

Язык: Английский

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The respiratory cycle modulates distinct dynamics of affective and perceptual decision-making

bioRxiv (Cold Spring Harbor Laboratory), Год журнала: 2024, Номер unknown

Опубликована: Март 28, 2024

Abstract Respiratory rhythms play a critical role not only in homeostatic survival, but also modulating other non-interoceptive perceptual and affective processes. Recent evidence from both human rodent models indicates that neural behavioural oscillations are influenced by respiratory state as breathing cycles inspiration to expiration. To explore the mechanisms behind these effects, we carried out psychophysical experiment where 41 participants categorised dot motion facial emotion stimuli standardised discrimination task. When comparing behaviour across states, found accelerated responses domains. We applied hierarchical accumulation model determine which aspects of latent decision process best explained this acceleration. Computational modelling showed reduced evidential boundaries, such prioritised speed over accuracy In contrast, shifted starting point accumulation, inducing bias towards categorising expressions more positive. These findings provide novel computational account how modulate distinct decision-dynamics.

Язык: Английский

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