The Psychology of learning and motivation/The psychology of learning and motivation, Год журнала: 2024, Номер unknown, С. 149 - 198
Опубликована: Янв. 1, 2024
Язык: Английский
Trends in Endocrinology and Metabolism, Год журнала: 2024, Номер 35(10), С. 884 - 901
Опубликована: Окт. 1, 2024
Язык: Английский
Процитировано
5
Neuron, Год журнала: 2025, Номер unknown
Опубликована: Март 1, 2025
Язык: Английский
Процитировано
0
Nature reviews. Neuroscience, Год журнала: 2025, Номер unknown
Опубликована: Март 26, 2025
Язык: Английский
Процитировано
0
Journal of the American Heart Association, Год журнала: 2025, Номер unknown
Опубликована: Март 31, 2025
Background Cardiovascular responses to psychological stressors have been separately associated with preclinical atherosclerosis and hemodynamic brain activity patterns across different studies cohorts; however, what has not established is whether cardiovascular stress reliably link indicators of stressor‐evoked that measured in the same individuals. Accordingly, present study used cross‐validation predictive modeling test for first time systolic blood pressure statistically mediated association between concurrently a vascular marker carotid arteries. Methods Results Six hundred twenty‐four midlife adults (aged 28–56 years, 54.97% women) from 2 cohorts underwent information‐conflict functional magnetic resonance imaging tasks, concurrent measures collected. Carotid artery intima‐media thickness was by ultrasonography. A mediation framework included harmonization, cross‐validation, penalized principal component regression then used. Brain areas where exhibited reliable direct indirect effects were identified through bootstrapping. Sensitivity analysis further tested robustness findings after accounting prevailing levels disease risk data quality. Task‐averaged distributed generalizable thickness, which an area under curve measure aggregate reactivity. Importantly, this effect held sensitivity analyses. Implicated ventromedial prefrontal cortex, anterior cingulate insula, amygdala. Conclusions These novel support atherosclerosis, accounted individual differences corresponding
Язык: Английский
Процитировано
0
medRxiv (Cold Spring Harbor Laboratory), Год журнала: 2024, Номер unknown
Опубликована: Фев. 6, 2024
ABSTRACT Background Cardiovascular responses to psychological stressors have been separately associated with preclinical atherosclerosis and hemodynamic brain activity patterns across different studies cohorts; however, what has not established is whether cardiovascular stress reliably link indicators of stressor-evoked that measured in the same individuals. Accordingly, present study used cross-validation predictive modeling test for first time systolic blood pressure (SBP) statistically mediated association between concurrently a vascular marker carotid arteries. Methods 624 midlife adults (aged 28-56 years, 54.97% female) from two cohorts underwent information-conflict fMRI tasks, concurrent SBP measures collected. Carotid artery intima-media thickness (CA-IMT) was by ultrasonography. A mediation framework included harmonization, cross-validation, penalized principal component regression then employed, while significant areas possible direct indirect effects were identified through bootstrapping. Sensitivity analysis further tested robustness findings after accounting prevailing levels disease risk imaging data quality control. Results Task-averaged exhibited generalizable CA-IMT, which an area-under-the-curve measure aggregate reactivity. Importantly, this effect held sensitivity analyses. Implicated ventromedial prefrontal cortex, anterior cingulate insula amygdala. Conclusions These novel support accounted individual differences corresponding
Язык: Английский
Процитировано
2
Scientific Reports, Год журнала: 2023, Номер 13(1)
Опубликована: Ноя. 1, 2023
Enamel forming ameloblasts move away from the dentino-enamel junction and also relative to each other establish enamel shape during secretory stage of development. Matrix metalloproteinase-20 (MMP20) is a tooth specific proteinase essential for proper formation. We previously reported that MMP20 cleaves cadherins may regulate ameloblast movement. Here, we used an Amelx promoter driven tdTomato reporter label mouse ameloblasts. With these transgenic mice, assessed mobility group dynamics gene expression. Three-dimensional imaging were observed in hemi-mandibles by using tissue clearing technique. The three-dimensional layer Tg(Amelx-Mmp20) mice overexpress was uneven migrated this layer. Mouse movement toward incisal tips monitored ex vivo time-lapse imaging. Gene expression related cell migration adhesion analyzed wild-type Mmp20
Язык: Английский
Процитировано
4
Journal of Child Psychology and Psychiatry, Год журнала: 2024, Номер unknown
Опубликована: Июнь 25, 2024
Background Early regulatory problems (RPs), i.e., with crying, sleeping, and/or feeding during the first years, increase risk for avoidant personality traits in adulthood, associated social withdrawal and anxiety. Even more, RPs are linked functional alterations adult default mode salience networks, comprising brain's allostatic‐interoceptive system (AIS) playing a role interactions. We investigated whether assessed infancy difficulties peer relationships mediated by of AIS. Methods As part large case‐controlled prospective study, 42 adults previous 70 matched controls (mean age = 28.48, SD 2.65, 51% male) underwent fMRI rest. The analysis focused on intrinsic connectivity (iFC) key nodes Peer relationship quality was via semi‐structured Life Course Interview YASR scale. In these same individuals, were at ages 5, 20 56 months. Results lower‐quality enhanced AIS stronger effect multiple persistent compared transient‐multiple or single‐persistent RPs. Importantly, iFC changes dorsal mid insula, primary interoceptive cortex frontal temporal regions, between early quality. Conclusions indicate long‐lasting neural Our findings further implicate both processes, while indicating need screening
Язык: Английский
Процитировано
1
Psychophysiology, Год журнала: 2024, Номер 61(11)
Опубликована: Июль 1, 2024
Resting heart rate may confer risk for cardiovascular disease (CVD) and other adverse events. While the brainstem's autonomic control over is well established, less known about regulatory role of higher level cortical subcortical brain regions, especially in humans. This study sought to characterize networks that predict variation prevailing otherwise healthy adults. We used machine learning approaches designed complex, high-dimensional data sets, instantaneous period (the inter-heartbeat-interval) from whole-brain hemodynamic signals measured by fMRI. Task-based resting-state fMRI, as peripheral physiological recordings, were taken two sets included extensive repeated measurements within individuals. Our models reliably predicted fMRI both across individuals, with prediction accuracies being highest when within-participants. found a network many linked visceral motor sensory processes, reliable predictors period. adds evidence on brain-heart interactions constitutes an incremental step toward developing clinically applicable biomarkers contributions CVD risk.
Язык: Английский
Процитировано
1
Neuroscience & Biobehavioral Reviews, Год журнала: 2024, Номер 166, С. 105874 - 105874
Опубликована: Сен. 6, 2024
Язык: Английский
Процитировано
1
The Psychology of learning and motivation/The psychology of learning and motivation, Год журнала: 2024, Номер unknown, С. 149 - 198
Опубликована: Янв. 1, 2024
Язык: Английский
Процитировано
0