Complementary cognitive roles for D2-MSNs and D1-MSNs during interval timing DOI Open Access

Robert A. Bruce,

Matthew A. Weber, Alexandra Bova

и другие.

Опубликована: Ноя. 19, 2024

The role of striatal pathways in cognitive processing is unclear. We studied dorsomedial during interval timing, an elementary task that requires mice to estimate intervals several seconds and involves working memory for temporal rules as well attention the passage time. harnessed optogenetic tagging record from D2- dopamine receptor-expressing medium spiny neurons (D2-MSNs) indirect pathway D1-dopamine MSNs (D1-MSNs) direct pathway. found D2-MSNs D1-MSNs exhibited distinct dynamics over quantified by principal component analyses trial-by-trial generalized linear models. MSN recordings helped construct constrain a four-parameter drift-diffusion computational model which ensemble activity represented accumulation evidence. This predicted disrupting either or would increase timing response times alter firing. In line with this prediction, we inhibition pharmacological disruption increased times. Pharmacologically also changed degraded decoding. Together, our findings demonstrate had opposing yet played complementary roles, implying work together shape control action. These data provide novel insight into basal ganglia operations beyond movement have implications human diseases therapies targeting pathways.

Язык: Английский

Subjective Time in Ordinary and Non-ordinary States of Consciousness: How Interoceptive Feelings Inform Us About the Passage of Time DOI
Marc Wittmann, Sylvie Droit‐Volet

Current topics in behavioral neurosciences, Год журнала: 2024, Номер unknown

Опубликована: Янв. 1, 2024

Язык: Английский

Процитировано

2
Complementary cognitive roles for D2-MSNs and D1-MSNs in interval timing DOI Open Access

Robert A. Bruce,

Matthew A. Weber, Alexandra Bova

и другие.

Опубликована: Март 27, 2024

The role of striatal pathways in cognitive processing is unclear. We studied dorsomedial during interval timing, an elementary task that requires mice to estimate intervals several seconds, which involves working memory for temporal rules as well attention the passage time. harnessed optogenetic tagging record from D2-dopamine receptor-expressing medium spiny neurons (D2-MSNs) indirect pathway and D1-dopamine MSNs (D1-MSNs) direct pathway. found D2-MSNs D1-MSNs exhibited opposing dynamics over quantified by principal component analyses trial-by-trial generalized linear models. MSN recordings helped construct constrain a four-parameter drift-diffusion computational model. This model predicted disrupting either D2-MSN or would increase timing response times alter firing. In line with this prediction, we inhibition pharmacological disruption increased times. Pharmacologically also times, shifted dynamics, degraded decoding. Together, our findings demonstrate make complementary contributions despite implying work together shape control action. These data provide novel insight into basal ganglia operations beyond movement have implications broad range human diseases therapies targeting pathways.

Язык: Английский

Процитировано

1
Same principle, but different computations in representing time and space DOI Creative Commons
Sepehr Sima, Mehdi Sanayei

Frontiers in Neuroscience, Год журнала: 2024, Номер 18

Опубликована: Май 7, 2024

Time and space are two intertwined contexts that frame our cognition of the world have shared mechanisms. A well-known theory on this case is "A Theory Magnitude (ATOM)" which states perception these domains shares common However, evidence regarding computations time intermixed. To investigate issue, we asked human subjects to reproduce distance intervals with saccadic eye movements in similarly designed tasks. We applied an observer model both modalities found underlying differences processing space. While probabilistic, adding priors minimally improved performance, as opposed was consistently better explained by Bayesian computations. also showed while measurement motor variability were smaller than reproduction, only correlated between them, tasks used for response. Our results suggest abide same algorithm but different computational properties.

Язык: Английский

Процитировано

1
Estimating Time and Rhythm by Predicting External Stimuli DOI

Mildred Salgado-Ménez,

Marisol Espinoza-Monroy,

Ana M. Malagón

и другие.

Advances in experimental medicine and biology, Год журнала: 2024, Номер unknown, С. 159 - 169

Опубликована: Янв. 1, 2024

Язык: Английский

Процитировано

1
The Motor of Time: Coupling Action to Temporally Predictable Events Heightens Perception DOI
Jennifer T. Coull, Inga Korolczuk, Benjamin Morillon

и другие.

Advances in experimental medicine and biology, Год журнала: 2024, Номер unknown, С. 199 - 213

Опубликована: Янв. 1, 2024

Язык: Английский

Процитировано

1
Space-time interference: The asymmetry we get out is the asymmetry we put in DOI Creative Commons
Martin Riemer, Zhenguang G. Cai

Neuroscience & Biobehavioral Reviews, Год журнала: 2024, Номер 167, С. 105941 - 105941

Опубликована: Ноя. 14, 2024

Temporal judgments are more affected by space than vice versa. This asymmetry has often been interpreted as primacy of spatial representations over temporal ones. interpretation is in line with conceptual metaphor theory that humans conceptualize time metaphors, but inconsistent the assumption a common neuronal magnitude system. Here we review accumulating evidence for genuinely symmetric interference between and discuss potential explanations to why asymmetric can arise, both respect interaction size duration, traveled distance travel time. Contrary view hierarchical space, our suggests be explained on basis working memory processes aspect speed inherent dynamic stimuli. We conclude get out (space affects versa) consequence put (by using biased paradigms stimuli facilitating processing).

Язык: Английский

Процитировано

1
Complementary cognitive roles for D2-MSNs and D1-MSNs during interval timing DOI Open Access

Robert A. Bruce,

Matthew A. Weber, Alexandra Bova

и другие.

bioRxiv (Cold Spring Harbor Laboratory), Год журнала: 2023, Номер unknown

Опубликована: Июль 28, 2023

The role of striatal pathways in cognitive processing is unclear. We studied dorsomedial during interval timing, an elementary task that requires mice to estimate intervals several seconds and involves working memory for temporal rules as well attention the passage time. harnessed optogenetic tagging record from D2-dopamine receptor-expressing medium spiny neurons (D2-MSNs) indirect pathway D1-dopamine MSNs (D1-MSNs) direct pathway. found D2-MSNs D1-MSNs exhibited distinct dynamics over quantified by principal component analyses trial-by-trial generalized linear models. MSN recordings helped construct constrain a four-parameter drift-diffusion computational model. This model predicted disrupting either or would increase timing response times alter firing. In line with this prediction, we inhibition pharmacological disruption increased times. Pharmacologically also changed degraded decoding. Together, our findings demonstrate make complementary contributions despite opposing dynamics, implying work together shape control action. These data provide novel insight into basal ganglia operations beyond movement have implications human diseases therapies targeting pathways.

Язык: Английский

Процитировано

2
Complementary opposing D2-MSNs and D1-MSNs dynamics during interval timing DOI Creative Commons

Robert A. Bruce,

Matthew A. Weber, Alexandra Bova

и другие.

eLife, Год журнала: 2024, Номер 13

Опубликована: Март 27, 2024

The role of striatal pathways in cognitive processing is unclear. We studied dorsomedial during interval timing, an elementary task that requires mice to estimate intervals several seconds and involves working memory for temporal rules as well attention the passage time. harnessed optogenetic tagging record from D2-dopamine receptor-expressing medium spiny neurons (D2-MSNs) indirect pathway D1-dopamine MSNs (D1-MSNs) direct pathway. found D2-MSNs D1-MSNs exhibited distinct dynamics over quantified by principal component analyses trial-by-trial generalized linear models. MSN recordings helped construct constrain a four-parameter drift-diffusion computational model which ensemble activity represented accumulation evidence. This predicted disrupting either or would increase timing response times alter firing. In line with this prediction, we inhibition pharmacological disruption increased times. Pharmacologically also changed degraded decoding. Together, our findings demonstrate had opposing yet played complementary roles, implying work together shape control action. These data provide novel insight into basal ganglia operations beyond movement have implications human diseases therapies targeting pathways.

Язык: Английский

Процитировано

0
Memory capacity as the core mechanism of the development of space–time interferences in children DOI Creative Commons
Quentin Hallez, Fuat Balcı

Scientific Reports, Год журнала: 2024, Номер 14(1)

Опубликована: Май 6, 2024

This study investigated the development of spatiotemporal perceptual interactions in 5-to-7 years old children. Participants reproduced temporal and spatial interval between sequentially presented visual stimuli. The time spacing stimuli were experimentally manipulated. In addition, cognitive capacities assessed using neuropsychological tests. Results revealed that starting at 5 old, children exhibited biases their estimations estimations, pointing space-time interference. line with developmental improvement abilities, these decreased age. Importantly, short-term memory capacity was a predictor interference to shared mechanisms space processing. Our results support symmetrical hypothesis proposes common neurocognitive mechanism for processing space.

Язык: Английский

Процитировано

0
Complementary opposing D2-MSNs and D1-MSNs dynamics during interval timing DOI Open Access

Robert A. Bruce,

Matthew A. Weber, Alexandra Bova

и другие.

Опубликована: Авг. 19, 2024

The role of striatal pathways in cognitive processing is unclear. We studied dorsomedial during interval timing, an elementary task that requires mice to estimate intervals several seconds and involves working memory for temporal rules as well attention the passage time. harnessed optogenetic tagging record from D2-dopamine receptor-expressing medium spiny neurons (D2-MSNs) indirect pathway D1-dopamine MSNs (D1-MSNs) direct pathway. found D2-MSNs D1-MSNs exhibited distinct dynamics over quantified by principal component analyses trial-by-trial generalized linear models. MSN recordings helped construct constrain a four-parameter drift-diffusion computational model. This model predicted disrupting either or would increase timing response times alter firing. In line with this prediction, we inhibition pharmacological disruption increased times. Pharmacologically also changed degraded decoding. Together, our findings demonstrate make complementary contributions despite opposing dynamics, implying work together shape control action. These data provide novel insight into basal ganglia operations beyond movement have implications human diseases therapies targeting pathways.

Язык: Английский

Процитировано

0