Complementary cognitive roles for D2-MSNs and D1-MSNs during interval timing DOI Open Access

Robert A. Bruce,

Matthew A. Weber, Alexandra Bova

et al.

Published: Nov. 19, 2024

The role of striatal pathways in cognitive processing is unclear. We studied dorsomedial during interval timing, an elementary task that requires mice to estimate intervals several seconds and involves working memory for temporal rules as well attention the passage time. harnessed optogenetic tagging record from D2- dopamine receptor-expressing medium spiny neurons (D2-MSNs) indirect pathway D1-dopamine MSNs (D1-MSNs) direct pathway. found D2-MSNs D1-MSNs exhibited distinct dynamics over quantified by principal component analyses trial-by-trial generalized linear models. MSN recordings helped construct constrain a four-parameter drift-diffusion computational model which ensemble activity represented accumulation evidence. This predicted disrupting either or would increase timing response times alter firing. In line with this prediction, we inhibition pharmacological disruption increased times. Pharmacologically also changed degraded decoding. Together, our findings demonstrate had opposing yet played complementary roles, implying work together shape control action. These data provide novel insight into basal ganglia operations beyond movement have implications human diseases therapies targeting pathways.

Language: Английский

Complementary cognitive roles for D2-MSNs and D1-MSNs in interval timing DOI Open Access

Robert A. Bruce,

Matthew A. Weber, Alexandra Bova

et al.

Published: March 27, 2024

The role of striatal pathways in cognitive processing is unclear. We studied dorsomedial during interval timing, an elementary task that requires mice to estimate intervals several seconds, which involves working memory for temporal rules as well attention the passage time. harnessed optogenetic tagging record from D2-dopamine receptor-expressing medium spiny neurons (D2-MSNs) indirect pathway and D1-dopamine MSNs (D1-MSNs) direct pathway. found D2-MSNs D1-MSNs exhibited opposing dynamics over quantified by principal component analyses trial-by-trial generalized linear models. MSN recordings helped construct constrain a four-parameter drift-diffusion computational model. This model predicted disrupting either D2-MSN or would increase timing response times alter firing. In line with this prediction, we inhibition pharmacological disruption increased times. Pharmacologically also times, shifted dynamics, degraded decoding. Together, our findings demonstrate make complementary contributions despite implying work together shape control action. These data provide novel insight into basal ganglia operations beyond movement have implications broad range human diseases therapies targeting pathways.

Language: Английский

Citations

1
Same principle, but different computations in representing time and space DOI Creative Commons
Sepehr Sima, Mehdi Sanayei

Frontiers in Neuroscience, Journal Year: 2024, Volume and Issue: 18

Published: May 7, 2024

Time and space are two intertwined contexts that frame our cognition of the world have shared mechanisms. A well-known theory on this case is "A Theory Magnitude (ATOM)" which states perception these domains shares common However, evidence regarding computations time intermixed. To investigate issue, we asked human subjects to reproduce distance intervals with saccadic eye movements in similarly designed tasks. We applied an observer model both modalities found underlying differences processing space. While probabilistic, adding priors minimally improved performance, as opposed was consistently better explained by Bayesian computations. also showed while measurement motor variability were smaller than reproduction, only correlated between them, tasks used for response. Our results suggest abide same algorithm but different computational properties.

Language: Английский

Citations

1
Estimating Time and Rhythm by Predicting External Stimuli DOI

Mildred Salgado-Ménez,

Marisol Espinoza-Monroy,

Ana M. Malagón

et al.

Advances in experimental medicine and biology, Journal Year: 2024, Volume and Issue: unknown, P. 159 - 169

Published: Jan. 1, 2024

Language: Английский

Citations

1
The Motor of Time: Coupling Action to Temporally Predictable Events Heightens Perception DOI
Jennifer T. Coull, Inga Korolczuk, Benjamin Morillon

et al.

Advances in experimental medicine and biology, Journal Year: 2024, Volume and Issue: unknown, P. 199 - 213

Published: Jan. 1, 2024

Language: Английский

Citations

1
Subjective Time in Ordinary and Non-ordinary States of Consciousness: How Interoceptive Feelings Inform Us About the Passage of Time DOI
Marc Wittmann, Sylvie Droit‐Volet

Current topics in behavioral neurosciences, Journal Year: 2024, Volume and Issue: unknown

Published: Jan. 1, 2024

Language: Английский

Citations

1
Complementary opposing D2-MSNs and D1-MSNs dynamics during interval timing DOI Creative Commons

Robert A. Bruce,

Matthew A. Weber, Alexandra Bova

et al.

eLife, Journal Year: 2024, Volume and Issue: 13

Published: March 27, 2024

The role of striatal pathways in cognitive processing is unclear. We studied dorsomedial during interval timing, an elementary task that requires mice to estimate intervals several seconds and involves working memory for temporal rules as well attention the passage time. harnessed optogenetic tagging record from D2-dopamine receptor-expressing medium spiny neurons (D2-MSNs) indirect pathway D1-dopamine MSNs (D1-MSNs) direct pathway. found D2-MSNs D1-MSNs exhibited distinct dynamics over quantified by principal component analyses trial-by-trial generalized linear models. MSN recordings helped construct constrain a four-parameter drift-diffusion computational model which ensemble activity represented accumulation evidence. This predicted disrupting either or would increase timing response times alter firing. In line with this prediction, we inhibition pharmacological disruption increased times. Pharmacologically also changed degraded decoding. Together, our findings demonstrate had opposing yet played complementary roles, implying work together shape control action. These data provide novel insight into basal ganglia operations beyond movement have implications human diseases therapies targeting pathways.

Language: Английский

Citations

0
Complementary opposing D2-MSNs and D1-MSNs dynamics during interval timing DOI Open Access

Robert A. Bruce,

Matthew A. Weber, Alexandra Bova

et al.

Published: Aug. 19, 2024

The role of striatal pathways in cognitive processing is unclear. We studied dorsomedial during interval timing, an elementary task that requires mice to estimate intervals several seconds and involves working memory for temporal rules as well attention the passage time. harnessed optogenetic tagging record from D2-dopamine receptor-expressing medium spiny neurons (D2-MSNs) indirect pathway D1-dopamine MSNs (D1-MSNs) direct pathway. found D2-MSNs D1-MSNs exhibited distinct dynamics over quantified by principal component analyses trial-by-trial generalized linear models. MSN recordings helped construct constrain a four-parameter drift-diffusion computational model. This model predicted disrupting either or would increase timing response times alter firing. In line with this prediction, we inhibition pharmacological disruption increased times. Pharmacologically also changed degraded decoding. Together, our findings demonstrate make complementary contributions despite opposing dynamics, implying work together shape control action. These data provide novel insight into basal ganglia operations beyond movement have implications human diseases therapies targeting pathways.

Language: Английский

Citations

0
Mechanically Induced Motor Tremors Disrupt the Perception of Time DOI Creative Commons
Keri Anne Gladhill, Rose De Kock, Weiwei Zhou

et al.

eNeuro, Journal Year: 2024, Volume and Issue: 11(9), P. ENEURO.0013 - 24.2024

Published: Sept. 1, 2024

Contemporary research has begun to show a strong relationship between movements and the perception of time. More specifically, concurrent serve both bias enhance time estimates. To explain these effects, we recently proposed mechanism by which provide secondary channel for estimating duration that is combined optimally with sensory However, critical test this framework introducing "noise" into movements, estimates should similarly become noisier. accomplish this, had human participants move robotic arm while intervals in either auditory or visual modalities (

Language: Английский

Citations

0
Neural Representation of Time across Complementary Reference Frames DOI Creative Commons
Yangwen Xu, Nicola Sartorato, Léo Dutriaux

et al.

bioRxiv (Cold Spring Harbor Laboratory), Journal Year: 2024, Volume and Issue: unknown

Published: Nov. 7, 2024

Summary Humans conceptualize time in terms of space, allowing flexible construals from various perspectives. We can travel internally through a timeline to remember the past and imagine future (i.e., mental travel) or watch an external standpoint have panoramic view history watching). However, neural mechanisms that support these temporal remain unclear. To investigate this, we asked participants learn fictional religious ritual 15 events. During fMRI scanning, they were guided consider event series either internal perspective different tasks. Behavioral results confirmed success our manipulation, showing expected symbolic distance effect internal-perspective task reverse external-perspective task. found activation level posterior partial cortex correlated positively with sequential but negatively In contrast, anterior hippocampus regardless observer’s These suggest stores memory sequences allocentrically perspective-agnostic manner. Conversely, parietal retrieves egocentrically optimal for current context. Such complementary allocentric egocentric representations both stability storage flexibility construals.

Language: Английский

Citations

0
Synchronous processing of temporal information across the hippocampus, striatum, and orbitofrontal cortex DOI Open Access
Akihiro Shimbo,

Y. Sekine,

Saori Kashiwagi

et al.

bioRxiv (Cold Spring Harbor Laboratory), Journal Year: 2024, Volume and Issue: unknown

Published: Nov. 11, 2024

ABSTRACT Information processing for interval timing is supported by several brain regions, including the hippocampus, basal ganglia, and frontal cortical areas. However, little known about mechanism which temporal information processed cooperatively in distributed network. Here, we investigated neuronal of hippocampal CA1, dorsal striatum, orbitofrontal cortex simultaneously recording activity during a bisection task. We found time cells representing elapsed period across all three regions. Seeking potential correlative representation time, that theta oscillations were dominant these areas modulated cells. Moreover, synchronization cell pairs was also regulated oscillations. Taken together, results demonstrated presence synchronous on fine scale, In addition, decoding analysis revealed correlated with rats’ decisions based their internal estimation, decoded showing correlations Thus, cooperative time-cell assemblies regions reflected recognition rats. conclusion, demonstrate pivotal role supporting

Language: Английский

Citations

0