The
role
of
striatal
pathways
in
cognitive
processing
is
unclear.
We
studied
dorsomedial
during
interval
timing,
an
elementary
task
that
requires
mice
to
estimate
intervals
several
seconds
and
involves
working
memory
for
temporal
rules
as
well
attention
the
passage
time.
harnessed
optogenetic
tagging
record
from
D2-
dopamine
receptor-expressing
medium
spiny
neurons
(D2-MSNs)
indirect
pathway
D1-dopamine
MSNs
(D1-MSNs)
direct
pathway.
found
D2-MSNs
D1-MSNs
exhibited
distinct
dynamics
over
quantified
by
principal
component
analyses
trial-by-trial
generalized
linear
models.
MSN
recordings
helped
construct
constrain
a
four-parameter
drift-diffusion
computational
model
which
ensemble
activity
represented
accumulation
evidence.
This
predicted
disrupting
either
or
would
increase
timing
response
times
alter
firing.
In
line
with
this
prediction,
we
inhibition
pharmacological
disruption
increased
times.
Pharmacologically
also
changed
degraded
decoding.
Together,
our
findings
demonstrate
had
opposing
yet
played
complementary
roles,
implying
work
together
shape
control
action.
These
data
provide
novel
insight
into
basal
ganglia
operations
beyond
movement
have
implications
human
diseases
therapies
targeting
pathways.
eNeuro,
Год журнала:
2024,
Номер
11(9), С. ENEURO.0013 - 24.2024
Опубликована: Сен. 1, 2024
Contemporary
research
has
begun
to
show
a
strong
relationship
between
movements
and
the
perception
of
time.
More
specifically,
concurrent
serve
both
bias
enhance
time
estimates.
To
explain
these
effects,
we
recently
proposed
mechanism
by
which
provide
secondary
channel
for
estimating
duration
that
is
combined
optimally
with
sensory
However,
critical
test
this
framework
introducing
"noise"
into
movements,
estimates
should
similarly
become
noisier.
accomplish
this,
had
human
participants
move
robotic
arm
while
intervals
in
either
auditory
or
visual
modalities
(
bioRxiv (Cold Spring Harbor Laboratory),
Год журнала:
2024,
Номер
unknown
Опубликована: Ноя. 7, 2024
Summary
Humans
conceptualize
time
in
terms
of
space,
allowing
flexible
construals
from
various
perspectives.
We
can
travel
internally
through
a
timeline
to
remember
the
past
and
imagine
future
(i.e.,
mental
travel)
or
watch
an
external
standpoint
have
panoramic
view
history
watching).
However,
neural
mechanisms
that
support
these
temporal
remain
unclear.
To
investigate
this,
we
asked
participants
learn
fictional
religious
ritual
15
events.
During
fMRI
scanning,
they
were
guided
consider
event
series
either
internal
perspective
different
tasks.
Behavioral
results
confirmed
success
our
manipulation,
showing
expected
symbolic
distance
effect
internal-perspective
task
reverse
external-perspective
task.
found
activation
level
posterior
partial
cortex
correlated
positively
with
sequential
but
negatively
In
contrast,
anterior
hippocampus
regardless
observer’s
These
suggest
stores
memory
sequences
allocentrically
perspective-agnostic
manner.
Conversely,
parietal
retrieves
egocentrically
optimal
for
current
context.
Such
complementary
allocentric
egocentric
representations
both
stability
storage
flexibility
construals.
bioRxiv (Cold Spring Harbor Laboratory),
Год журнала:
2024,
Номер
unknown
Опубликована: Ноя. 11, 2024
ABSTRACT
Information
processing
for
interval
timing
is
supported
by
several
brain
regions,
including
the
hippocampus,
basal
ganglia,
and
frontal
cortical
areas.
However,
little
known
about
mechanism
which
temporal
information
processed
cooperatively
in
distributed
network.
Here,
we
investigated
neuronal
of
hippocampal
CA1,
dorsal
striatum,
orbitofrontal
cortex
simultaneously
recording
activity
during
a
bisection
task.
We
found
time
cells
representing
elapsed
period
across
all
three
regions.
Seeking
potential
correlative
representation
time,
that
theta
oscillations
were
dominant
these
areas
modulated
cells.
Moreover,
synchronization
cell
pairs
was
also
regulated
oscillations.
Taken
together,
results
demonstrated
presence
synchronous
on
fine
scale,
In
addition,
decoding
analysis
revealed
correlated
with
rats’
decisions
based
their
internal
estimation,
decoded
showing
correlations
Thus,
cooperative
time-cell
assemblies
regions
reflected
recognition
rats.
conclusion,
demonstrate
pivotal
role
supporting
The
role
of
striatal
pathways
in
cognitive
processing
is
unclear.
We
studied
dorsomedial
during
interval
timing,
an
elementary
task
that
requires
mice
to
estimate
intervals
several
seconds
and
involves
working
memory
for
temporal
rules
as
well
attention
the
passage
time.
harnessed
optogenetic
tagging
record
from
D2-
dopamine
receptor-expressing
medium
spiny
neurons
(D2-MSNs)
indirect
pathway
D1-dopamine
MSNs
(D1-MSNs)
direct
pathway.
found
D2-MSNs
D1-MSNs
exhibited
distinct
dynamics
over
quantified
by
principal
component
analyses
trial-by-trial
generalized
linear
models.
MSN
recordings
helped
construct
constrain
a
four-parameter
drift-diffusion
computational
model
which
ensemble
activity
represented
accumulation
evidence.
This
predicted
disrupting
either
or
would
increase
timing
response
times
alter
firing.
In
line
with
this
prediction,
we
inhibition
pharmacological
disruption
increased
times.
Pharmacologically
also
changed
degraded
decoding.
Together,
our
findings
demonstrate
had
opposing
yet
played
complementary
roles,
implying
work
together
shape
control
action.
These
data
provide
novel
insight
into
basal
ganglia
operations
beyond
movement
have
implications
human
diseases
therapies
targeting
pathways.
