Space-time interference: The asymmetry we get out is the asymmetry we put in

Neuroscience & Biobehavioral Reviews, Journal Year: 2024, Volume and Issue: 167, P. 105941 - 105941

Published: Nov. 14, 2024

Temporal judgments are more affected by space than vice versa. This asymmetry has often been interpreted as primacy of spatial representations over temporal ones. interpretation is in line with conceptual metaphor theory that humans conceptualize time metaphors, but inconsistent the assumption a common neuronal magnitude system. Here we review accumulating evidence for genuinely symmetric interference between and discuss potential explanations to why asymmetric can arise, both respect interaction size duration, traveled distance travel time. Contrary view hierarchical space, our suggests be explained on basis working memory processes aspect speed inherent dynamic stimuli. We conclude get out (space affects versa) consequence put (by using biased paradigms stimuli facilitating processing).

Language: Английский

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Complementary cognitive roles for D2-MSNs and D1-MSNs during interval timing

bioRxiv (Cold Spring Harbor Laboratory), Journal Year: 2023, Volume and Issue: unknown

Published: July 28, 2023

The role of striatal pathways in cognitive processing is unclear. We studied dorsomedial during interval timing, an elementary task that requires mice to estimate intervals several seconds and involves working memory for temporal rules as well attention the passage time. harnessed optogenetic tagging record from D2-dopamine receptor-expressing medium spiny neurons (D2-MSNs) indirect pathway D1-dopamine MSNs (D1-MSNs) direct pathway. found D2-MSNs D1-MSNs exhibited distinct dynamics over quantified by principal component analyses trial-by-trial generalized linear models. MSN recordings helped construct constrain a four-parameter drift-diffusion computational model. This model predicted disrupting either or would increase timing response times alter firing. In line with this prediction, we inhibition pharmacological disruption increased times. Pharmacologically also changed degraded decoding. Together, our findings demonstrate make complementary contributions despite opposing dynamics, implying work together shape control action. These data provide novel insight into basal ganglia operations beyond movement have implications human diseases therapies targeting pathways.

Language: Английский

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Memory capacity as the core mechanism of the development of space–time interferences in children

Scientific Reports, Journal Year: 2024, Volume and Issue: 14(1)

Published: May 6, 2024

This study investigated the development of spatiotemporal perceptual interactions in 5-to-7 years old children. Participants reproduced temporal and spatial interval between sequentially presented visual stimuli. The time spacing stimuli were experimentally manipulated. In addition, cognitive capacities assessed using neuropsychological tests. Results revealed that starting at 5 old, children exhibited biases their estimations estimations, pointing space-time interference. line with developmental improvement abilities, these decreased age. Importantly, short-term memory capacity was a predictor interference to shared mechanisms space processing. Our results support symmetrical hypothesis proposes common neurocognitive mechanism for processing space.

Language: Английский

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Direct and Inverse Problems of Time Encoding by Neuron-Like Agents

Published: Jan. 1, 2024

Language: Английский

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Complementary cognitive roles for D2-MSNs and D1-MSNs during interval timing

Published: Nov. 19, 2024

The role of striatal pathways in cognitive processing is unclear. We studied dorsomedial during interval timing, an elementary task that requires mice to estimate intervals several seconds and involves working memory for temporal rules as well attention the passage time. harnessed optogenetic tagging record from D2- dopamine receptor-expressing medium spiny neurons (D2-MSNs) indirect pathway D1-dopamine MSNs (D1-MSNs) direct pathway. found D2-MSNs D1-MSNs exhibited distinct dynamics over quantified by principal component analyses trial-by-trial generalized linear models. MSN recordings helped construct constrain a four-parameter drift-diffusion computational model which ensemble activity represented accumulation evidence. This predicted disrupting either or would increase timing response times alter firing. In line with this prediction, we inhibition pharmacological disruption increased times. Pharmacologically also changed degraded decoding. Together, our findings demonstrate had opposing yet played complementary roles, implying work together shape control action. These data provide novel insight into basal ganglia operations beyond movement have implications human diseases therapies targeting pathways.

Language: Английский

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