Gut–Brain Axis and Brain Microbiome Interactions from a Medical Perspective

Brain Sciences, Год журнала: 2025, Номер 15(2), С. 167 - 167

Опубликована: Фев. 8, 2025

Background: The gut microbiome directly impacts brain health and activity, meaning the two are closely associated. This relationship suggests a link between microbial imbalances diseases such as Alzheimer’s, although multiple other contributing factors, genetics, also play part. Additionally, recent studies discovered that cerebrospinal fluid has some deoxyribonucleic acid (DNA), which can be interpreted to mean exists in too. vagus nerve central nervous immune systems responsible for connection microbiome. Aims Objectives: main aim of this systematic review is analyze existing research on gut–brain axis fill current knowledge gap. Materials Methods: A search was conducted PubMed database based set predefined MeSH terms. Results: After search, 2716 articles meeting parameters were found PubMed. list then downloaded analyzed according inclusion/exclusion criteria, 63 relevant papers selected. Discussion: Bacteria produce substances considered neuroactive. These compounds or indirectly affect function through axis. However, various gaps mechanisms involved need addressed first.

Язык: Английский

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Morinda officinalis oligosaccharides alleviate chronic unpredictable mild stress-induced depression through the BDNF/TrkB/CREB pathway and symptoms of sexual dysfunction in mice

Frontiers in Neuroscience, Год журнала: 2025, Номер 18

Опубликована: Янв. 8, 2025

In recent years, depression has become a global public health concern, and one of the common concomitant symptoms are diminished sexual motivation impaired performance. The aim this study was to investigate potential effects Morinda officinalis oligosaccharides (MOO) on its symptom, dysfunction. Chronic unpredictable mild stress (CUMS)-induced model constructed, MOO abilities were evaluated. results revealed that able alleviate CUMS-induced depression-like behavior in mice, inhibit hippocampal neuron apoptosis, reverse monoamine neurotransmitter imbalance, increase Brain-derived neurotrophic factor (BDNF) expression levels hippocampus, modulate composition distribution gut microbiota, abundance probiotics after continuous gavage for 28 days. further confirmed dysfunction is closely related development by improving lack low performance depressed modulating disruption sex hormone secretion serum, alleviating sperm morphology functional defects epididymis. These findings provide basis exploring antidepressant mechanism, use improve hypogonadotropic symptoms, future new drug improves symptoms.

Язык: Английский

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Bifidobacterium adolescentis-derived nicotinic acid improves host skeletal muscle mitochondrial function to ameliorate sarcopenia

Cell Reports, Год журнала: 2025, Номер 44(2), С. 115265 - 115265

Опубликована: Фев. 1, 2025

Sarcopenia significantly diminishes quality of life and increases mortality risk in older adults. While the connection between gut microbiome muscle health is recognized, underlying mechanisms are poorly understood. In this study, shotgun metagenomics revealed that Bifidobacterium adolescentis notably depleted individuals with sarcopenia, correlating reduced mass function. This finding was validated aged mice. Metabolomics analysis identified nicotinic acid as a key metabolite produced by B. adolescentis, linked to improvements functionality sarcopenia. Mechanistically, restores nicotinamide adenine dinucleotide (NAD+) levels muscle, inhibits FoxO3/Atrogin-1/Murf-1 axis, promotes satellite cell proliferation, reducing atrophy. Additionally, NAD+ activation enhances silent-information-regulator 1 (SIRT1)/peroxisome-proliferator-activated-receptor-γ-coactivator 1-alpha (PGC-1α) stimulating mitochondrial biogenesis promoting oxidative metabolism slow-twitch fibers, ultimately improving Our findings suggest adolescentis-derived could be promising therapeutic strategy for

Язык: Английский

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Multi-omics analysis reveals mechanisms of FMT in Enhancing antidepressant effects of SSRIs

Brain Behavior and Immunity, Год журнала: 2025, Номер unknown

Опубликована: Фев. 1, 2025

Язык: Английский

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Ginkgo Biloba as a niche theme cognitive enhancer agent, 1420 dokumen of Scopus database. A bibliometric study from 1988 to 2024

F1000Research, Год журнала: 2025, Номер 14, С. 275 - 275

Опубликована: Март 7, 2025

1) Introduction Cognitive enhancers, also known as nootropics, aim to improve cognitive functions, such memory and attention. Despite their potential benefits, the challenges include scientific validation, ethical considerations, regulatory hurdles. This bibliometric study analyzes literature from Scopus identify key trends, influential authors, research gaps, providing guidance for future research. 2) Methods employs a review methodology gather data database on Neuroaid, analyzing it using Biblioshiny VOSviewer software. The focus was Ginkgo Biloba niche-theme enhancer agent based data, both quantitative qualitative analyses. 3) Results discussion biloba, 'maidenhair tree’ order Ginkgoales, appeared 290 million years ago. Chinese Japanese culture has been cultivated thousands of years. tree is valued its resilience therapeutic properties, often used in traditional medicine respiratory blood circulation issues. 4) Conclusions enhancers aims provide comprehensive systematic existing literature, highlighting gaps. findings this will contribute better understanding current state inform conducted December 2024.

Язык: Английский

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Gut microbiome characteristics in individuals across different stages of schizophrenia spectrum disorders: A systematic review and meta-analysis

Neuroscience & Biobehavioral Reviews, Год журнала: 2025, Номер unknown, С. 106167 - 106167

Опубликована: Апрель 1, 2025

Язык: Английский

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Antipsychotics and dietary interventions: pharmacodynamics, pharmacokinetics and synergisms in therapy

Pharmacological Reviews, Год журнала: 2025, Номер unknown, С. 100061 - 100061

Опубликована: Апрель 1, 2025

Язык: Английский

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