Anesteziologie a intenzivní medicína,
Год журнала:
2024,
Номер
35(5), С. 301 - 304
Опубликована: Дек. 19, 2024
Článek
přináší
výběr
zajímavých
událostí,
jakým
byl
Světový
den
bolesti,
zejména
v
návaznosti
Evropský
který
následuje
vždy
třetí
středu
říjnu.
Vliv
Evropské
unie
na
léčbu
bolesti
aktuálně
vydaném
dokumentu
zmiňuje
léky
proti
nicméně
je
zájem
EU
o
problematiku
chronické
zatím
spíše
okrajový.
IASP
mezinárodní
společnost
pro
vyhlásila
rok
2024
globálním
rokem
genderových
rozdílů
bolesti.
se
snažilo
osvětlit
toto
důležité
téma
průběhu
celosvětového
roku
a
dosáhnout
změny
přístupu
chápání
jak
u
lékařů,
tak
pacientů.
Jak
mohou
genderové
rozdíly
interagovat
s
mechanismy
způsobujícími
nebo
udržujícími
bolest,
posledních
letech
oblastí
rostoucího
zájmu.
Nové
poznatky
byly
publikovány
kanabidiolu,
bude
nutná
regulace
nejen
výroby,
ale
také
prodeje
reklamy.
Aktuálně
roce
vydán
první
pokyn
klinickou
praxi
Americké
akademie
pediatrů
(AAP),
přístupy
založené
důkazech
k
bezpečnému
předepisování
opioidů
akutní
bolest
pediatrické
populace
ambulantních
zařízeních.
Hlavním
cílem
pomoci
lékařům
pochopit,
kdy
být
opioidy
indikovány
léčbě
dětí
dospívajících
minimalizovat
rizika
užíváním
opioidů.
Acta Materia Medica,
Год журнала:
2025,
Номер
4(3)
Опубликована: Янв. 1, 2025
Neurologic
disorders
are
the
leading
cause
of
illness
and
disability
as
a
result
increased
life
expectancy
global
population
aging,
highlighting
urgent
need
great
challenge
for
discovering
neuroprotective
agents
with
better
efficacy
minimal
side-effects.
Catalpol,
an
iridoid
glycoside
derived
from
Rehmanniae
Radix,
has
therapeutic
potential
in
neurologic
diseases
due
to
its
diverse
biological
activities.
This
review
summarizes
research
advances
catalpol
wide
range
disorders,
including
depression,
cognitive
impairment,
stroke,
Parkinson’s
disease,
multiple
sclerosis.
A
comprehensive
discussion
experimental
models
used,
dosages,
duration
treatment,
mechanisms
involved
is
provided.
The
common
underlying
effects
on
these
closely
related
antioxidant,
anti-neuroinflammatory,
anti-apoptotic
properties,
well
capacity
promote
neuroplasticity
neurogenesis.
Despite
promising
results
studies,
there
still
challenges
be
addressed,
such
identifying
direct
binding
targets,
assessing
toxicologic
effects,
understanding
pharmacokinetics.
Furthermore,
well-designed
controlled
clinical
trials
should
conducted
validate
safety
treating
various
conditions.
provides
compelling
evidence
supporting
natural
agent.
British Journal of Anaesthesia,
Год журнала:
2025,
Номер
unknown
Опубликована: Май 1, 2025
Chronic
pain
disproportionately
affects
women,
but
the
reasons
for
this
disparity
are
unclear.
We
investigated
from
a
genetic
perspective
using
data
UK
Biobank,
focusing
on
multi-site
chronic
pain,
which
is
highly
heritable
and
manifests
sex
bias.
Genome-wide
association
studies
(GWAS)
revealed
that
women
have
approximately
4500
sex-specific
causal
loci
overlapping
pains-four
times
more
than
men-accounting
their
higher
heritability.
Heritability
partitioning
indicated
pain-related
primarily
enriched
in
brain
regions,
only
women.
Additionally,
200
imaging-derived
phenotypes
were
significantly
associated
with
compared
six
men.
GWAS
of
these
showed
stronger
correlations
particularly
regarding
cortical
thickness
striatal
volume.
When
disentangling
pleiotropy
causation
genetically
correlated
pairs
brain-
traits,
we
found
genetics
often
causally
implicated
presence
Our
findings
suggest
play
crucial
role
increased
risk
observed
Journal of Clinical Investigation,
Год журнала:
2025,
Номер
135(11)
Опубликована: Июнь 1, 2025
Chronic
pain
affects
more
than
50
million
Americans,
with
women
disproportionately
affected
by
severe
pain,
interference,
and
overall
disability.
The
development
of
chronic
is
multifactorial
often
begins
an
incident
acute
associated
injury
or
a
surgical
procedure
that
transitions
to
persistent
lasting
for
months
years.
Despite
this,
there
are
limited
clinical
studies
investigating
sex
differences
in
predictors
biomarkers
the
transition
pain.
Several
preclinical
animal
models
have
been
developed
gain
better
understanding
mechanisms
several
sex-specific
identified
across
multiple
systems.
These
generally
involve
multiple-insult
approach,
which
priming
insult
enhances
sensitivity
subsequent
induction
stimulus.
There
emerging
evidence
from
research
male-specific
female-specific
mechanisms,
as
well
showing
shared
mechanisms.
Here,
we
review
literature
covering
periphery
immune
system,
central
nervous
endocrine
system
related
We
further
highlight
gaps
provide
recommendations
future
understand
Scientific Reports,
Год журнала:
2024,
Номер
14(1)
Опубликована: Дек. 30, 2024
Bone
cancer
pain
(BCP)
is
a
common
clinical
problem
in
patients.
The
plasticity
of
excitatory
neurons
within
the
spinal
dorsal
horn
plays
significant
role
development
BCP.
This
study
explored
roles
absent
melanoma
2
(AIM2)
and
stimulator
interferon
gene
(STING)
BCP
using
male
C57BL/6J
mice.
Cancers
cells
were
cultured
implanted
into
tibia
to
induce
pain-like
behavior.
AIM2-RNAi
lentivirus
was
injected
or
STING
agonist
intraperitoneally.
protein
expressions
localization
evaluated
by
qRT-PCR
WB
IF,
respectively.
mechanical
threshold
measured
von
Frey
test.
Immunofluorescence
showed
that
AIM2
co-localized
cord
neurons,
expressed
presynaptic
membrane.
western
blotting
expression
increased,
decreased
Inhibition
enhanced
reduced
GluN1,
attenuated
allodynia.
After
injecting
agonist,
increased
GluN1
decreased.
These
results
emphasizes
involvement
downregulating
increasing
expression.
bioRxiv (Cold Spring Harbor Laboratory),
Год журнала:
2024,
Номер
unknown
Опубликована: Авг. 8, 2024
Abstract
Hyperalgesic
priming
is
a
model
system
that
has
been
widely
used
to
understand
plasticity
in
painful
stimulus-detecting
sensory
neurons,
called
nociceptors.
A
key
feature
of
this
following
priming,
stimuli
do
not
normally
cause
hyperalgesia
now
readily
provoke
state.
We
hypothesized
hyperalgesic
occurs
due
reorganization
translation
mRNA
To
test
hypothesis,
we
paclitaxel
treatment
as
the
stimulus
and
translating
ribosome
affinity
purification
(TRAP)
measure
persistent
changes
Nav1.8+
TRAP
sequencing
revealed
161
genes
with
persistently
altered
primed
identified
Gpr88
upregulated
Metrn
downregulated.
confirmed
functional
role
for
these
genes,
wherein
GPR88
agonist
causes
pain
only
mice
established
reversed
by
Meteorin.
Our
work
demonstrates
nociceptor
translatomes
are
causative
producing
priming.
