Graph
neural
networks
(GNNs)
have
recently
been
applied
to
develop
useful
diagnostic
tools
for
psychiatric
disorders.
However,
due
the
lack
of
interpretability,
clinicians
are
hard
identify
quantifiable
and
personalizable
biomarkers
which
provide
biologically
clinically
relevance.
We
introduce
three
proposed
GNN-based
disorders
models,
namely
BrainIB,
Graph-PRI
CI-GNN,
from
an
information-theoretic
perspective.
These
models
able
discriminate
patients
healthy
controls
predictive
subgraph,
a.k.a.
biomarkers,
solely
observations.
demonstrate
their
improved
classification
accuracy
interpretability
on
ABIDE
database.
also
put
forward
proposals
future
research.
IEEE Access,
Год журнала:
2024,
Номер
12, С. 15145 - 15170
Опубликована: Янв. 1, 2024
Graph
neural
network
(GNN)
is
a
formidable
deep
learning
framework
that
enables
the
analysis
and
modeling
of
intricate
relationships
present
in
data
structured
as
graphs.
In
recent
years,
burgeoning
interest
has
arisen
exploiting
latent
capabilities
GNN
for
healthcare-based
applications,
capitalizing
on
their
aptitude
complex
unearthing
profound
insights
from
graph-structured
data.
However,
to
best
our
knowledge,
no
study
systemically
reviewed
studies
conducted
healthcare
domain.
This
furnished
an
all-encompassing
erudite
overview
prevailing
cutting-edge
research
healthcare.
Through
assimilation
studies,
current
trends,
recurrent
challenges,
promising
future
opportunities
applications
have
been
identified.
China
emerged
leading
country
conduct
GNN-based
domain,
followed
by
USA,
UK,
Turkey.
Among
various
aspects
healthcare,
disease
prediction
drug
discovery
emerge
most
prominent
areas
focus
application,
indicating
potential
advancing
diagnostic
therapeutic
approaches.
proposed
questions
regarding
diverse
domain
addressed
them
through
in-depth
analysis.
can
provide
practitioners
researchers
with
into
landscape
guide
institutes,
researchers,
governments
demonstrating
ways
which
contribute
development
effective
efficient
systems.
Diagnostics,
Год журнала:
2025,
Номер
15(2), С. 153 - 153
Опубликована: Янв. 10, 2025
Background:
Alzheimer’s
disease
is
a
progressive
neurological
condition
marked
by
decline
in
cognitive
abilities.
Early
diagnosis
crucial
but
challenging
due
to
overlapping
symptoms
among
impairment
stages,
necessitating
non-invasive,
reliable
diagnostic
tools.
Methods:
We
applied
information
geometry
and
manifold
learning
analyze
grayscale
MRI
scans
classified
into
No
Impairment,
Very
Mild,
Moderate
Impairment.
Preprocessed
images
were
reduced
via
Principal
Component
Analysis
(retaining
95%
variance)
converted
statistical
manifolds
using
estimated
mean
vectors
covariance
matrices.
Geodesic
distances,
computed
with
the
Fisher
Information
metric,
quantified
class
differences.
Graph
Neural
Networks,
including
Convolutional
Networks
(GCN),
Attention
(GAT),
GraphSAGE,
utilized
categorize
levels
graph-based
representations
of
data.
Results:
Significant
differences
structures
observed,
increased
variability
stronger
feature
correlations
at
higher
levels.
distances
between
Impairment
Mild
(58.68,
p<0.001)
(58.28,
are
statistically
significant.
GCN
GraphSAGE
achieve
perfect
classification
accuracy
(precision,
recall,
F1-Score:
1.0),
correctly
identifying
all
instances
across
classes.
GAT
attains
an
overall
59.61%,
variable
performance
Conclusions:
Integrating
geometry,
learning,
GNNs
effectively
differentiates
AD
stages
from
The
strong
indicates
their
potential
assist
clinicians
early
identification
tracking
progression.
Abstract
Deep
learning
models
have
shown
promise
in
diagnosing
neurodevelopmental
disorders
(NDD)
like
ASD
and
ADHD.
However,
many
either
use
graph
neural
networks
(GNN)
to
construct
single-level
brain
functional
(BFNs)
or
employ
spatial
convolution
filtering
for
local
information
extraction
from
rs-fMRI
data,
often
neglecting
high-order
features
crucial
NDD
classification.
We
introduce
a
Multi-view
High-order
Network
(MHNet)
capture
hierarchical
multi-view
BFNs
derived
data
prediction.
MHNet
has
two
branches:
the
Euclidean
Space
Features
Extraction
(ESFE)
module
Non-Euclidean
(Non-ESFE)
module,
followed
by
Feature
Fusion-based
Classification
(FFC)
identification.
ESFE
includes
Functional
Connectivity
Generation
(FCG)
Convolutional
Neural
(HCNN)
extract
space.
Non-ESFE
comprises
Generic
Internet-like
Brain
Hierarchical
(G-IBHN-G)
Graph
(HGNN)
topological
non-Euclidean
Experiments
on
three
public
datasets
show
that
outperforms
state-of-the-art
methods
using
both
AAL1
Brainnetome
Atlas
templates.
Extensive
ablation
studies
confirm
superiority
of
effectiveness
fMRI
features.
Our
study
also
offers
atlas
options
constructing
more
sophisticated
explains
association
between
key
regions
NDD.
leverages
feature
spaces,
incorporating
enhance
classification
performance.
Frontiers in Psychiatry,
Год журнала:
2025,
Номер
16
Опубликована: Фев. 20, 2025
Introduction
Autism
Spectrum
Disorder
(ASD)
identification
poses
significant
challenges
due
to
its
multifaceted
and
diverse
nature,
necessitating
early
discovery
for
operative
involvement.
In
a
recent
study,
there
has
been
lot
of
talk
about
how
deep
learning
algorithms
might
improve
the
diagnosis
ASD
by
analyzing
neuroimaging
data.
Method
To
overrule
negatives
current
techniques,
this
research
proposed
revolutionary
strategic
model
called
Unified
Transformer
Block
Multi-View
Graph
Attention
Networks
(MVUT_GAT).
For
purpose
extracting
delicate
outlines
from
physical
efficient
functional
MRI
data,
MVUT_GAT
combines
advantages
multi-view
with
attention
processes.
Result
With
use
ABIDE
dataset,
thorough
analysis
shows
that
performs
better
than
Mutli-view
Site
Convolution
Network
(MVS_GCN),
outperforming
it
in
accuracy
+3.40%.
This
enhancement
reinforces
our
suggested
model’s
effectiveness
identifying
ASD.
The
result
implications
over
higher
metrics.
Through
improving
consistency
diagnosis,
will
help
interference
assistance
patients.
Discussion
Moreover,
MVUT_GAT’s
which
patches
distance
between
models
medical
visions
helping
identify
biomarkers
linked
end,
effort
advances
knowledge
recognizing
autism
spectrum
disorder
along
powerful
ability
enhance
results
value
people
who
are
undergone.
Abstract
In
this
paper,
we
develop
a
generic
framework
for
systemically
encoding
causal
knowledge
manifested
in
the
form
of
hierarchical
causality
structure
and
qualitative
(or
quantitative)
relationships
into
neural
networks
to
facilitate
sound
risk
analytics
decision
support
via
causally‐aware
intervention
reasoning.
The
proposed
methodology
establishing
causality‐informed
network
(CINN)
follows
four‐step
procedure.
first
step,
explicate
how
directed
acyclic
graph
(DAG)
can
be
discovered
from
observation
data
or
elicited
domain
experts.
Next,
categorize
nodes
constructed
DAG
representing
among
observed
variables
several
groups
(e.g.,
root
nodes,
intermediate
leaf
nodes),
align
architecture
CINN
with
specified
while
preserving
orientation
each
existing
relationship.
addition
dedicated
design,
also
gets
embodied
design
loss
function,
where
both
are
treated
as
target
outputs
predicted
by
CINN.
third
propose
incorporate
on
stable
CINN,
injected
constraints
act
guardrails
prevent
unexpected
behaviors
Finally,
trained
is
exploited
perform
reasoning
emphasis
estimating
effect
that
policies
actions
have
system
behavior,
thus
facilitating
risk‐informed
making
through
comprehensive
“what‐if”
analysis.
Two
case
studies
used
demonstrate
substantial
benefits
enabled
support.
Patterns,
Год журнала:
2024,
Номер
5(12), С. 101081 - 101081
Опубликована: Ноя. 4, 2024
This
study
developed
an
artificial
intelligence
(AI)
system
using
a
local-global
multimodal
fusion
graph
neural
network
(LGMF-GNN)
to
address
the
challenge
of
diagnosing
major
depressive
disorder
(MDD),
complex
disease
influenced
by
social,
psychological,
and
biological
factors.
Utilizing
functional
MRI,
structural
electronic
health
records,
offers
objective
diagnostic
method
integrating
individual
brain
regions
population
data.
Tested
across
cohorts
from
China,
Japan,
Russia
with
1,182
healthy
controls
1,260
MDD
patients
24
institutions,
it
achieved
classification
accuracy
78.75%,
area
under
receiver
operating
characteristic
curve
(AUROC)
80.64%,
correctly
identified
subtypes.
The
further
discovered
distinct
connectivity
patterns
in
MDD,
including
reduced
between
left
gyrus
rectus
right
cerebellar
lobule
VIIB,
increased
Rolandic
operculum
hippocampus.
Anatomically,
is
associated
thickness
changes
gray
white
matter
interface,
indicating
potential
neuropathological
conditions
or
injuries.