Long-Term Brain Disorders in Post Covid-19 Neurological Syndrome (PCNS) Patient

Brain Sciences, Год журнала: 2021, Номер 11(4), С. 454 - 454

Опубликована: Апрель 2, 2021

In the recent pandemic disease, called COVID-19, role of neurologists and neurobiologists represents a chance to study key features brain infection deepen neurological manifestations COVID-19 other coronavirus infections. fact, many studies suggest damage during persistent symptoms after infection. Reverse transcription PCR test, antibody tests, Computed Tomography (CT) lung, Magnetic Resonance (MR) patient were periodically performed this case report for eight months The aim article is describe prolonged clinical consequences related COVID-19. We believe it clinically clear that we can define post-acute syndrome. Therefore, in patients severe condition deepening signs necessary.

Язык: Английский

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Microbiota-derived short-chain fatty acids do not interfere with SARS-CoV-2 infection of human colonic samples

Gut Microbes, Год журнала: 2021, Номер 13(1), С. 1 - 9

Опубликована: Янв. 1, 2021

Microbiota-derived molecules called short-chain fatty acids (SCFAs) play a key role in the maintenance of intestinal barrier and regulation immune response during infectious conditions. Recent reports indicate that SARS-CoV-2 infection changes microbiota SCFAs production. However, relevance this effect is unknown. In study, we used human biopsies epithelial cells to investigate impact by SARS-CoV-2. did not change entry or replication cells. These metabolites had no on cells' permeability presented only minor effects production anti-viral inflammatory mediators. Together our findings composition patients with COVID-19 and, particularly, do interfere intestine.

Язык: Английский

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Pharmacological Significance of Hesperidin and Hesperetin, Two Citrus Flavonoids, as Promising Antiviral Compounds for Prophylaxis Against and Combating COVID-19

Natural Product Communications, Год журнала: 2021, Номер 16(10)

Опубликована: Окт. 1, 2021

Hesperidin and hesperetin are flavonoids that abundantly present as constituents of citrus fruits. These compounds have attracted attention several computational methods, mostly docking studies, shown hesperidin may bind to multiple regions severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) (spike protein, angiotensin-converting enzyme 2, proteases). has a low binding energy, both with the SARS-CoV-2 “spike” protein responsible for internalization, also “PL pro ” “M transforming early proteins virus into complex viral replication. This suggests these could act prophylactic agents by blocking mechanisms infection replication, thus helping host cell resist attack.

Язык: Английский

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SARS-CoV-2 Infects Primary Neurons from Human ACE2 Expressing Mice and Upregulates Genes Involved in the Inflammatory and Necroptotic Pathways

Pathogens, Год журнала: 2022, Номер 11(2), С. 257 - 257

Опубликована: Фев. 17, 2022

Transgenic mice expressing human angiotensin-converting enzyme 2 under the cytokeratin 18 promoter (K18-hACE2) have been extensively used to investigate pathogenesis and tissue tropism of severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) infection. Neuroinvasion replication SARS-CoV-2 within central nervous system (CNS) K18-hACE2 is associated with increased mortality; although, mechanisms by which this occurs remain unclear. In study, we generated primary neuronal cultures from effects a We also evaluated immunological response infection in CNS mouse cultures. Our data show that obtained are permissive support productive virus replication. Furthermore, upregulated expression genes involved innate immunity inflammation, including IFN-α, ISG-15, CXCL10, CCL2, IL-6 TNF-α, neurons brains. addition, found brains activates ZBP1/pMLKL-regulated necroptosis pathway. Together, our provide insights into neuropathogenesis mice.

Язык: Английский

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Ginkgo Biloba and Long COVID: In Vivo and In Vitro Models for the Evaluation of Nanotherapeutic Efficacy

Pharmaceutics, Год журнала: 2023, Номер 15(5), С. 1562 - 1562

Опубликована: Май 22, 2023

Coronavirus infections are neuroinvasive and can provoke injury to the central nervous system (CNS) long-term illness consequences. They may be associated with inflammatory processes due cellular oxidative stress an imbalanced antioxidant system. The ability of phytochemicals anti-inflammatory activities, such as Ginkgo biloba, alleviate neurological complications brain tissue damage has attracted strong ongoing interest in neurotherapeutic management long COVID. biloba leaf extract (EGb) contains several bioactive ingredients, e.g., bilobalide, quercetin, ginkgolides A–C, kaempferol, isorhamnetin, luteolin. have various pharmacological medicinal effects, including memory cognitive improvement. through its anti-apoptotic, antioxidant, impacts function other conditions like those While preclinical research on therapies for neuroprotection shown promising results, clinical translation remains slow challenges (e.g., low drug bioavailability, limited half-life, instability, restricted delivery target tissues, poor capacity). This review emphasizes advantages nanotherapies using nanoparticle approaches overcome these challenges. Various experimental techniques shed light molecular mechanisms underlying response help comprehend pathophysiology sequelae SARS-CoV-2 infection. To develop novel therapeutic agents systems, methods mimicking been used lipid peroxidation products, mitochondrial respiratory chain inhibitors, models ischemic damage). We hypothesize beneficial effects EGb COVID-19 symptoms, evaluated either vitro or vivo animal stress.

Язык: Английский

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Neurological manifestations of COVID-19: a systematic review and detailed comprehension

International Journal of Neuroscience, Год журнала: 2021, Номер 133(7), С. 754 - 769

Опубликована: Авг. 26, 2021

The current pandemic caused by severe acute respiratory syndrome corona virus 2 (SARS-CoV-2) is accompanied with a rapid increase of reports and papers detailing its neurological effects symptoms. infection causes illness named the world health organization as 19 (COVID-19).This systematic review aims to study summarize different manifestations this virus. All articles published indexed via Pubmed, Medline Google Scholar databases between January 1st 2020 February 28th 2021 that reported symptoms SARS-CoV-2 are reviewed following Preferred Reporting Items for Systemic Meta-Analysis (PRISMA) guidelines.We included data from 113 articles: eight prospective studies, 25 retrospective studies rest were case reports/series. COVID-19 can present central nervous system manifestations, such headache, encephalitis encephalopathy, peripheral anosmia, ageusia Guillian Barre syndrome, skeletal muscle myalgia myasthenia gravis. Our showed be manifested wide spectrum either in early stage or within course disease. However, detailed comprehension these required more needed order improve our scientific knowledge develop preventive therapeutic measures control pandemic.

Язык: Английский

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New Neuroprotective Effect of Lemon IntegroPectin on Neuronal Cellular Model

Antioxidants, Год журнала: 2021, Номер 10(5), С. 669 - 669

Опубликована: Апрель 25, 2021

Lemon IntegroPectin obtained via hydrodynamic cavitation of organic lemon processing waste in water shows significant neuroprotective activity vitro, as first reported this study investigating the effects both and commercial citrus pectin on cell viability, morphology, reactive oxygen species (ROS) production, mitochondria perturbation induced by treatment neuronal SH-SY5Y human cells with H2O2. Mediated ROS, including H2O2 its derivatives, oxidative stress alters numerous cellular processes, such mitochondrial regulation signaling, propagating injury that leads to incurable neurodegenerative diseases. These results, absence toxicity new pectic substance rich adsorbed flavonoids terpenes, suggest further studies investigate preventing, retarding, or even curing neurological

Язык: Английский

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Antioxidant Genetic Profile Modifies Probability of Developing Neurological Sequelae in Long-COVID

Antioxidants, Год журнала: 2022, Номер 11(5), С. 954 - 954

Опубликована: Май 12, 2022

Understanding the sequelae of COVID-19 is utmost importance. Neuroinflammation and disturbed redox homeostasis are suggested as prevailing underlying mechanisms in neurological propagation long-COVID. We aimed to investigate whether variations antioxidant genetic profile might be associated with Neurological examination (SOD2, GPXs GSTs) determination, well as, genotype analysis Nrf2 ACE2, were conducted on 167 patients. Polymorphisms determined by appropriate PCR methods. Only polymorphisms GSTP1AB GSTO1 independently long-COVID manifestations. Indeed, individuals carrying GSTP1 Val or Asp allele exhibited lower odds myalgia development, both combination. Furthermore, combined presence Ile Ala alleles cumulative risk regarding carriers GPX1 LeuLeu/GPX3 CC genotype. Moreover, GSTM1-null/GPX1LeuLeu more prone developing "brain fog", while this probability further enlarged if A was also present. The fact that certain variants enzymes, combination, affect manifestations, emphasizes involvement susceptibility when SARS-CoV-2 infection initiated host cells, months after.

Язык: Английский

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Rutin: A Potential Antiviral for Repurposing as a SARS-CoV-2 Main Protease (M^pro) Inhibitor

Natural Product Communications, Год журнала: 2021, Номер 16(4)

Опубликована: Апрель 1, 2021

Various computational studies, including in silico ones, have identified several existing compounds that could serve as effective inhibitors of the SARS-CoV-2 main protease (M pro ), and thus preventing replication virus. Among these, rutin has been a potential hit, having prominent binding affinity to Moreover, its presence traditional antiviral medicines prescribed China infected patients with mild moderate symptoms COVID-19 justify promise repurposed bioactive secondary metabolite against SARS-CoV-2.

Язык: Английский

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Neurological Consequences, Mental Health, Physical Care, and Appropriate Nutrition in Long-COVID-19

Cellular and Molecular Neurobiology, Год журнала: 2022, Номер 43(5), С. 1685 - 1695

Опубликована: Сен. 14, 2022

SARS-CoV-2 pandemic has caused a collapse of the world health systems. Now, vaccines and more effective therapies have reversed this crisis but scenario is further aggravated by appearance new pathology, occurring as infection consequence: long-COVID-19. This term commonly used to describe signs symptoms that continue or develop after acute COVID-19 up several months. In review, consequences disease on mental neurological implications due long-COVID are described. Furthermore, appropriate nutritional approach some recommendations relieve pathology presented. Data collected indicated in next future will affect an increasing number individuals interdisciplinary action needed counteract it.

Язык: Английский

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