Post-COVID Syndrome: An Insight on Its Pathogenesis

Vaccines, Год журнала: 2021, Номер 9(5), С. 497 - 497

Опубликована: Май 12, 2021

Post-COVID syndrome is increasingly recognized as a new clinical entity in the context of SARS-CoV-2 infection. Symptoms persisting for more than three weeks after diagnosis COVID-19 characterize post-COVID syndrome. Its incidence ranges from 10% to 35%, however, rates high 85% have been reported among patients with history hospitalization. Currently, there no consensus on classification We reviewed published information syndrome, putting emphasis its pathogenesis. The pathogenesis multi-factorial and one mechanism may be implicated several manifestations. Prolonged inflammation has key role account some neurological complications, cognitive dysfunction, other symptoms. A multisystem inflammatory adults (MIS-A) all ages also described recently, similarly children (MIS-C). post-infectious pathogenetic MIS-A supported by fact that established through serology up third cases. Other mechanisms are include immune-mediated vascular thromboembolism, nervous system dysfunction. Although current data indicating overwhelming majority good prognosis, registries actively follow them needed order define full spectrum long-term outcome. consensus-based essential guide clinical, diagnostic, therapeutic management. Further research imperative elucidate

Язык: Английский

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The Impact of COVID-19 Traumatic Stressors on Mental Health: Is COVID-19 a New Trauma Type

International Journal of Mental Health and Addiction, Год журнала: 2021, Номер 21(1), С. 51 - 70

Опубликована: Июль 6, 2021

COVID-19 is a new type of trauma that has never been conceptually or empirically analyzed in our discipline. This study aimed to investigate the impact as traumatic stress on mental health after controlling for individuals' previous stressors and traumas. We utilized sample (N = 1374) adults from seven Arab countries. used an anonymous online questionnaire included measures stress, posttraumatic disorder, anxiety, depression, cumulative conducted hierarchical multiple regression, with anxiety dependent variables. In first step, each analysis, we entered country, gender, age, religion, education, income independent variables (Kira, Traumatology 7(2):73–86, 2001; Kira, Torture, 14:38–44, 2004; Traumatology, 2021, https://doi.org/10.1037/trm0000305). second traumas variable. third either one its subtypes (fears infection, economic, lockdown) Finally, structural equation modeling PTSD, predictors latent variable Results indicated stressors, three subtypes, were unique depression. Thus, serious effects.

Язык: Английский

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Persistent neurological manifestations in long COVID-19 syndrome: A systematic review and meta-analysis

Journal of Infection and Public Health, Год журнала: 2022, Номер 15(8), С. 856 - 869

Опубликована: Июнь 23, 2022

Several studies have reported prolonged symptoms especially neurological following acute infection in patients with COVID-19, known as long COVID-19. There are only few investigating this population and relatively less known, including nervous system involvement. A systematic review meta-analysis of these required to understanding the prevalence persistent manifestations after

Язык: Английский

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Long-COVID diagnosis: From diagnostic to advanced AI-driven models

European Journal of Radiology, Год журнала: 2022, Номер 148, С. 110164 - 110164

Опубликована: Янв. 19, 2022

Язык: Английский

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Brain Imaging Changes in Patients Recovered From COVID-19: A Narrative Review

Frontiers in Neuroscience, Год журнала: 2022, Номер 16

Опубликована: Апрель 22, 2022

The severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) has caused several outbreaks of highly contagious diseases worldwide. symptoms Coronavirus Disease-19 (COVID-19) have been closely monitored and studied, while the central nervous system (CNS) peripheral (PNS) lesions induced by COVID-19 not received much attention. Currently, patients with COVID-19-associated encephalopathy present dizziness, headache, anxiety depression, stroke, epileptic seizures, Guillain-Barre (GBS), demyelinating disease. exact pathologic basis for these neurological is currently known. Rapid mutation SARS-CoV-2 genome leads to appearance variants concern (VOCs), which higher infectivity virulence. Therefore, this narrative review will focus on imaging assessment its VOC. There an increase in technologies, such as [18F]fluorodeoxyglucose positron emission tomography (18F-FDG-PET) functional magnetic resonance (fMRI), that used observe changes brain microstructure over time recovery. Medical pathological approaches aimed at exploring associations between VOC, cranial nerve abnormal discharge shed light rehabilitation process microstructural related SARS-CoV-2, aid future research our understanding treatment prognosis encephalopathy.

Язык: Английский

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Neurological manifestations of SARS-CoV-2: complexity, mechanism and associated disorders

European journal of medical research, Год журнала: 2023, Номер 28(1)

Опубликована: Авг. 30, 2023

Abstract Background Coronaviruses such as Severe Acute Respiratory Syndrome coronavirus (SARS), Middle Eastern (MERS) and Coronavirus 2 (SARS-CoV-2) are associated with critical illnesses, including severe respiratory disorders. SARS-CoV-2 is the causative agent of deadly COVID-19 illness, which has spread globally a pandemic. may enter human body through olfactory lobes interact angiotensin-converting enzyme2 (ACE2) receptor, further facilitating cell binding entry into cells. Reports have shown that virus can pass blood–brain barrier (BBB) central nervous system (CNS), resulting in various Cell by largely relies on TMPRSS2 cathepsin L, activate S protein. found surface respiratory, gastrointestinal urogenital epithelium, while cathepsin-L part endosomes. Aim The current review aims to provide information how infection affects brain function.. Furthermore, CNS disorders infection, ischemic stroke, cerebral venous thrombosis, Guillain–Barré syndrome, multiple sclerosis, meningitis, encephalitis, discussed. many probable mechanisms paths involved developing cerebrovascular problems COVID patients thoroughly detailed. Main There been reports cross where it could cause illnesses. Patients suffering from experience range neurological complications, sleep disorders, viral headaches, dysgeusia, cognitive impairment. presence cerebrospinal fluid (CSF) reported. Health experts also reported its cortical neurons organoids. possible mechanism infiltration be neurotropic, direct cytokine storm-based pathways. primary pathway for entrance brain. Conclusions lead manifestations, motor movement decline. result symptoms diseases, strokes thrombosis. affect neural system, disrupt function To combat epidemic, crucial repurpose drugs currently use quickly develop novel therapeutics.

Язык: Английский

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Post-Acute COVID-19 Neurological Syndrome: A New Medical Challenge

Journal of Clinical Medicine, Год журнала: 2021, Номер 10(9), С. 1947 - 1947

Опубликована: Май 1, 2021

In December 2019, in Wuhan (China), a highly pathogenic coronavirus, named SARS-CoV-2, dramatically emerged. This new virus, which causes severe pneumonia, is rapidly spreading around the world, hence it provoked COVID-19 pandemic. emergency launched by SARS-CoV-2 also had, and still has, devastating socio-economic aspects. Assessing impact of on vulnerable groups people crucial for adaptation governments' responses. Growing scientific evidence suggests that essential to keep attention after acute infection; indeed, some clinical manifestations are frequently present even recovery. There consensus need define symptoms persist infection disabilities may arise COVID-19. Recent reviews, case reports, original contributions suggest various organs be affected, neurological about one third patients with Neurological complications might include delirium, brain inflammation, stroke, nerve damage. recent pandemic, neurologists neurobiologists have chance study key features neurology. Furthermore, psychological pandemic should not underestimated, although there currently no definition this condition.

Язык: Английский

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Depressive and Neurocognitive Disorders in the Context of the Inflammatory Background of COVID-19

Life, Год журнала: 2021, Номер 11(10), С. 1056 - 1056

Опубликована: Окт. 8, 2021

The dysfunctional effects of the coronavirus disease 2019 (COVID-19) infection on nervous system are established. manifestation neuropsychiatric symptoms during and after is influenced by neuroinvasive neurotrophic properties SARS-CoV-2 as well strong inflammation characterised a specific “cytokine storm”. Research suggests that immune response to psychological stressors related pandemic may cause chronic inflammatory processes in body with elevated levels markers contributing intensification neurodegenerative processes. It suggested neuroinflammation associated central changes significantly contribute etiopathogenesis depressive disorders. In addition, COVID-19 persist for up several weeks an acute post-COVID-19 syndrome. Moreover, previous knowledge indicates among SSRI (selective serotonin reuptake inhibitor) group antidepressants, fluoxetine promising drug against COVID-19. conclusion, further research, observation broadening pathomechanism impact potential complications necessary. essential continue research order assess long-term patients find new therapeutic strategies.

Язык: Английский

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Imaging and neuropathological findings in patients with Post COVID-19 Neurological Syndrome—A review

Frontiers in Neurology, Год журнала: 2023, Номер 14

Опубликована: Фев. 9, 2023

Post COVID-19 syndrome is determined as signs and symptoms that appear during or after an infection consistent with SARS-CoV-2 disease, persist for more than 12 weeks are not explained by alternative diagnosis. This review presents the neuropathological findings imaging in Neurological Syndrome: focal point on manifestations of involvement evident brain spine imaging.

Язык: Английский

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The Role of Endothelium in COVID-19

International Journal of Molecular Sciences, Год журнала: 2021, Номер 22(21), С. 11920 - 11920

Опубликована: Ноя. 3, 2021

The 2019 novel coronavirus, known as severe acute respiratory syndrome-coronavirus 2 (SARS-CoV-2) or coronavirus disease (COVID-19), is causing a global pandemic. virus primarily affects the upper and lower tracts raises risk of variety non-pulmonary consequences, most possibly fatal which are cardiovascular problems. Data show that almost one-third patients with moderate form COVID-19 had preexisting comorbidities such diabetes mellitus, obesity, hypertension, heart failure, coronary artery disease. SARS-CoV2 causes hyper inflammation, hypoxia, apoptosis, renin-angiotensin system imbalance in cell types, endothelial cells. Profound dysfunction associated can be cause impaired organ perfusion may generate myocardial injury, renal procoagulant state resulting thromboembolic events. We discuss recent results on involvement pathogenesis cardiometabolic diseases this review. also provide insights treatments reduce severity viral infection.

Язык: Английский

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