Neuroscience Research, Год журнала: 2024, Номер unknown
Опубликована: Ноя. 1, 2024
Neuroscience & Biobehavioral Reviews, Год журнала: 2025, Номер unknown, С. 106039 - 106039
Опубликована: Фев. 1, 2025
Social interactions are vital for various taxa and species. Prosocial affiliative dynamics within a group between individuals not only pleasurable rewarding, but also appear to actively contribute well-being, cognitive performance, disease prevention. Moreover, disturbances in acting or being prosocial can represent major burden an individual their affective partners. These disruptions evident across spectrum of neuropsychiatric conditions, including depression autism disorders. Importantly, interactive patterns behavior vary with sex. The fact that genders differentially affected by disorders associated social impairment underscores the high importance this research uncovering underlying neural correlates mechanisms. This review focuses on elucidating sex-related differences behaviors potential association sexually different correlates. Specifically, we aim shed light complex interplay sex, behavior, neurobiology interaction patterns.
Язык: Английский
Процитировано
1
Neuron, Год журнала: 2023, Номер 111(24), С. 3911 - 3925
Опубликована: Окт. 6, 2023
Understanding how individuals form and maintain strong social networks has emerged as a significant public health priority result of the increased focus on epidemic loneliness myriad protective benefits conferred by connection. In this review, we highlight psychological neural mechanisms that enable us to connect with others, which in turn help buffer against consequences stress isolation. Central process is experience rewards derived from positive interactions, encourage sharing perspectives preferences unite individuals. Sharing affective states others helps align our understanding world another's, thereby continuing reinforce bonds strengthen relationships. These processes depend systems supporting reward cognitive function. Lastly, also consider limitations associated pursuing healthy connections outline potential avenues future research.
Язык: Английский
Процитировано
19
Neuroscience & Biobehavioral Reviews, Год журнала: 2023, Номер 156, С. 105504 - 105504
Опубликована: Дек. 6, 2023
Animals respond to changes in the environment which affect their internal state by adapting behaviors. Social isolation is a form of passive environmental stressor that alters animal behaviors across kingdom, including humans, rodents, and fruit flies. known increase violence, disrupt sleep depression leading poor mental physical health. Recent evidence from several model organisms suggests social leads remodeling transcriptional epigenetic landscape behavioral outcomes. In this review, we explore how manipulating experience fly Drosophila melanogaster can shed light on molecular neuronal mechanisms underlying driven We discuss recent advances made using powerful genetic toolkit assays uncover role neuromodulators, sensory modalities, pheromones, circuits mediating isolation. The insights gained these studies could be crucial for developing effective therapeutic interventions future.
Язык: Английский
Процитировано
14
Biological Psychiatry, Год журнала: 2025, Номер unknown
Опубликована: Янв. 1, 2025
Язык: Английский
Процитировано
0
Deleted Journal, Год журнала: 2025, Номер 7(1), С. 12 - 12
Опубликована: Фев. 18, 2025
Background: Exposure to violent content through video games can shape perceptions of aggression as normative or acceptable, potentially desensitizing adolescents violence and increasing the likelihood that they will engage in aggressive behavior their real-world interactions. This narrative review examines relationship between (VVGs) youth aggression, addressing (i) VVG exposure lens Social Learning Theory General Aggression Model; (ii) biological determinants behavior, including neurophysiological correlates potential modulatory role gut microbiome; (iii) current evidence on influence adolescent aggression. Results: may promote moral disengagement reinforce rewarding actions, leading real-life VVGs increases by elevating cortisol levels, activating sympathetic nervous system, stimulating brain’s reward disrupting neurotransmitter balance. Alterations microbiome composition could occur a result engaging VVGs, mirroring physiological responses observed activities. The among has been widely explored, with studies generally indicating lead desensitization violence, reduced empathy, diminished prosocial behavior. have also linked both bullying perpetration victimization dynamics adolescents, contributing mental health issues, which turn exacerbate problematic gaming behaviors. Conclusions: While there is suggesting associated increased discrepancies literature highlight need for further research aimed at improving our understanding this phenomenon. topic reveal significant limitations, predominance cross-sectional designs, methodological shortcomings, small sample sizes, challenges generalizing results. Factors such developmental stages participants, exclusion females, unmeasured variables during long follow-up periods complicate interpretations. Moreover, parental responsibility effectiveness age ratings require closer examination.
Язык: Английский
Процитировано
0
Neurobiology of Stress, Год журнала: 2023, Номер 25, С. 100546 - 100546
Опубликована: Май 29, 2023
Adverse social experiences during childhood increase the risk of developing aggression-related psychopathologies. The prefrontal cortex (PFC) is a key regulator behavior, where experience-dependent network development tied to maturation parvalbumin-positive (PV+) interneurons. Maltreatment in could impact PFC and lead disturbances behavior later life. However, our knowledge regarding early-life stress on operation PV+ cell function still scarce. Here, we used post-weaning isolation (PWSI) model neglect mice study associated neuronal changes PFC, additionally distinguishing between two main subpopulations interneurons, i.e. those without or enwrapped by perineuronal nets (PNN). For first time such detailed extent mice, show that PWSI induced including abnormal aggression, excessive vigilance fragmented behavioral organization. showed altered resting-state fighting-induced co-activation patterns orbitofrontal medial (mPFC) subregions, with particularly highly elevated activity mPFC. Surprisingly, aggressive interaction was higher recruitment mPFC neurons were surrounded PNN seemed mediate emergence deficits. did not affect number density, but enhanced PV intensity as well cortical subcortical glutamatergic drive onto neurons. Our results suggest increased excitatory input cells emerge compensatory mechanism for neuron-mediated impaired inhibition layer 5 pyramidal neurons, since found lower numbers GABAergic puncta perisomatic region these cells. In conclusion, leads PV-PNN excitatory/inhibitory balance mPFC, which possibly contributes disruptions seen mice. data advances understanding how can maturing abnormalities adulthood.
Язык: Английский
Процитировано
7
Veterinary World, Год журнала: 2023, Номер unknown
Опубликована: Авг. 1, 2023
Background and Aim: Social isolation stress (SIS) individual housing have been shown to cause abnormal cognitive insufficiencies, altered anxiety levels, signs of psychiatric diseases. Acorus calamus (AC), commonly known as Sweet Flag, has widely used in India treat neurological, metabolic, respiratory disorders, indicating its potential therapeutic value. This study aimed determine the antidepressant antioxidative effects AC on rats subjected long-term, social-isolation-induced stress. Materials Methods: involved 2-month-old male (24) weighing approximately 180200 g bred in-house. The were divided into four groups (n = 6): Group-1 received saline, Group-2 SIS, Group-3 only 50mg/kg AC, Group-4 SIS for 6 weeks. After this, behavioral, biochemical, neuronal assay was conducted. Results: Behavioral experiments showed significantly higher activity levels (p < 0.001) AC-treated than group. In addition, with treatment exhibited enhanced total antioxidants, superoxide dismutase, assays compared alone. Conclusion: improved antioxidant against rat brain tissue. Moreover, we proved that can effectively reverse neurotoxicity induced by animal models. As battle coronavirus disease 2019 pandemic social isolation, could be considered a supplementary alleviate depressive-like symptoms our present-day lifestyle. Keywords: antidepressant, effects, tissue, pandemic.
Язык: Английский
Процитировано
7
Neuroscience Research, Год журнала: 2023, Номер 202, С. 39 - 51
Опубликована: Ноя. 24, 2023
Anger transition is often abrupt. In this study, we investigated the mechanisms responsible for switching and modulating aggression levels. The cerebellum considered a center motor coordination learning; however, its connection to social behavior has long been observed. Here, used resident-intruder paradigm in male mice examined local field potential (LFP) changes, glial cytosolic ion fluctuations, vascular dynamics cerebellar vermis throughout various phases of combat sequence. Notably, observed emergence theta-band oscillations LFP sustained elevations Ca2+ levels during breakups. When astrocytes, including Bergmann cells, were photoactivated using channelrhodopsin-2, emerged an early breakup occurred. Within single sequence, rapid alteration offensive (fight) passive (flight) responses observed, which roughly correlated with decreases increases Ca2+, respectively. Neuron-glial interactions may play role adjusting Purkinje cell excitability setting tone aggression. Future anger management strategies clinical control excessive violent be realized by developing therapeutic strategy that adjusts activity cerebellum.
Язык: Английский
Процитировано
5
Frontiers in Nutrition, Год журнала: 2024, Номер 11
Опубликована: Май 3, 2024
Introduction Monosodium glutamate (MSG), an umami substance, stimulates the gut-brain axis communication via gut receptors and subsequent vagus nerves. However, brain mechanism underlying effect of MSG ingestion during developmental period on aggression has not yet been clarified. We first tried to establish new experimental conditions be more appropriate for detailed analysis brain, then investigated effects aggressive behavior stage ADHD rat model. Methods Long-Evans, WKY/Izm, SHR/Izm, SHR-SP/Ezo were individually housed from postnatal day 25 5 weeks. Post-weaning social isolation (PWSI) was given escalate behavior. The resident-intruder test, that is conducted subjective night, used a aggression, including frequency, duration, latency anogenital sniffing, grooming, attack Immunohistochemistry c-Fos expression in all strains predict potential aggression-related areas. Finally, most strain, known model attention-deficit hyperactivity disorder (ADHD), investigate (60 mM solution) followed by immunostaining Bilateral subdiaphragmatic vagotomy performed verify importance interactions MSG. Results resident intruder test revealed SHR/Izm rats among four parameters tested. also showed highest number + cells areas, central amygdala (CeA). significantly decreased frequency duration grooming increased Furthermore, administration successfully positive cell intermediate nucleus solitary tract (iNTS), terminal gastrointestinal sensory afferent fiber nerve, modulated CeA. Interestingly, diminished iNTS Conclusion PWSI-induced which mediated nerve related stimulation modulation CeA activity.
Язык: Английский
Процитировано
1
Biomedical & Pharmacology Journal, Год журнала: 2024, Номер 17(2), С. 687 - 697
Опубликована: Июнь 25, 2024
The leaves of Centella asiatica L. Urban (C. asiatica) and their bioactive compounds, triterpenoids asiaticoside (AS) madecassoside (MA), are effective in reducing psychological stress associated behavioral disorders the conducted vivo research. present study evaluated AS+MA-based standardized C. extract (INDCA) on SIS-induced suicidal behavior-related traits laboratory rats. Male rats (n=6) were randomized, grouped, individually caged for seven days induction. For next (D7 to D14), orally administered vehicle (stress control), positive control (fluoxetine, 30 mg/kg), or INDCA (3, 10, mg/kg) once a day. A separate group without isolation (normal rats) was maintained. scores traits, such as aggression, impulsivity, irritability, learned helplessness, plasma cortisol, measured after 14-day treatment. showed significant increase irritability (total score), helplessness (escape latency, escape failure, recovery attempts), cortisol levels, which confirmed traits. INDCA-treated dose-dependent reduction stress-induced elevated levels. In conclusion, subacute administration amelioration behavior social-isolation-induced suggested promising natural safe option management disorders, including behavior.
Язык: Английский
Процитировано
1