The Role of Sleep in Cardiovascular Disease

Current Atherosclerosis Reports, Год журнала: 2024, Номер 26(7), С. 249 - 262

Опубликована: Май 25, 2024

Sleep is an important component of cardiovascular (CV) health. This review summarizes the complex relationship between sleep and CV disease (CVD). Additionally, we describe data supporting treatment disturbances in preventing treating CVD.

Язык: Английский

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Social network site addiction, sleep quality, depression and adolescent difficulty describing feelings: a moderated mediation model

BMC Psychology, Год журнала: 2025, Номер 13(1)

Опубликована: Янв. 20, 2025

Язык: Английский

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Mechanisms, consequences and role of interventions for sleep deprivation: Focus on mild cognitive impairment and Alzheimer’s disease in elderly

Ageing Research Reviews, Год журнала: 2024, Номер 100, С. 102457 - 102457

Опубликована: Авг. 17, 2024

Язык: Английский

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Scn1a haploinsufficiency in the prefrontal cortex engages to cognitive impairment and depressive phenotype

Brain, Год журнала: 2024, Номер unknown

Опубликована: Май 21, 2024

Abstract Altered development and function of the prefrontal cortex (PFC) during adolescence is implicated in origin mental disorders. Deficits GABAergic system prominently contribute to these alterations. Nav1.1 a voltage-gated Na+ channel critical for normal activity. Here, we studied role PFC its potential relationship with aetiology Dysfunction activity medial (mPFC) adolescent mice enhanced local excitation/inhibition ratio, resulting epileptic activity, cognitive deficits depressive-like behaviour adulthood, along gene expression profile linked major depressive disorder (MDD). Additionally, it reduced extracellular serotonin concentration dorsal raphe nucleus brain-derived neurotrophic factor hippocampus, two MDD-related brain areas beyond PFC. We also observed alterations oscillatory impaired hippocampal-mPFC coherence sleep. Finally, found levels SCN1A, encoding Nav1.1, post-mortem samples from human MDD subjects. Collectively, our results provide novel mechanistic framework linking adolescence-specific pathogenesis epilepsy comorbidities such as impairment

Язык: Английский

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Smart home-assisted anomaly detection system for older adults: a deep learning approach with a comprehensive set of daily activities

Medical & Biological Engineering & Computing, Год журнала: 2025, Номер unknown

Опубликована: Янв. 31, 2025

Язык: Английский

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Melanin-concentrating hormone: A promising target for antidepressant treatment

Pharmacology Biochemistry and Behavior, Год журнала: 2025, Номер 250, С. 173999 - 173999

Опубликована: Март 11, 2025

Язык: Английский

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Hypersomnia as a predictor of response to intravenous ketamine/intranasal esketamine in treatment resistant depression

Journal of Affective Disorders, Год журнала: 2024, Номер 349, С. 272 - 276

Опубликована: Янв. 8, 2024

Язык: Английский

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Associations of exposure to volatile organic compounds with sleep health and potential mediators: analysis of NHANES data

Frontiers in Public Health, Год журнала: 2024, Номер 12

Опубликована: Июль 15, 2024

Objective The effect of environmental pollution on sleep has been widely studied, yet the relationship between exposure to volatile organic compounds (VOCs) and health requires further exploration. We aimed investigate single mixed urinary VOC metabolites identify potential mediators. Methods Data for this cross-sectional study was collected from National Health Nutrition Examination Surveys (NHANES) (2005–2006, 2011–2014). A weighted multivariate logistic regression established explore associations 16 VOCs with four outcomes. Following selection important through least absolute shrinkage operator (LASSO) regression, principal component analyses (PCA), weight quantile sum (WQS), Bayesian kernel machine (BKMR) were conducted outcomes, as well most contributing components. mediation analysis performed depression scores. Results Of 3,473 participants included in study, a total 618 diagnosed poor patterns. In analyses, 7, 10, 1, 5 significantly positively correlated patterns, abnormal duration, trouble sleeping, disorders, respectively. PCA showed that PC1 substantially linked higher risk patterns its WQS model revealed positive association mixture increased concentrations [OR (95% CI): 1.285 (1.107, 1.493)], duration 1.154 (1.030, 1.295)], sleeping 1.236 (1.090, 1.403)] disorders 1.378 (1.118, 1.705)]. BKMR found overall disorders. PCA, WQS, models all confirmed significant role N -acetyl- S -( -methylcarbamoyl)- l -cysteine (AMCC) score mediator index Conclusion Exposure negatively affected American population, AMCC playing role. shown mediate mixtures

Язык: Английский

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An in vitro analysis of an innovative standardized phospholipid carrier-based Melissa officinalis L. extract as a potential neuromodulator for emotional distress and related conditions

Frontiers in Molecular Biosciences, Год журнала: 2024, Номер 11

Опубликована: Март 13, 2024

Background: Melissa officinalis L. (MO), commonly known as lemon balm, a member of the mint family, is considered calming herb. In various traditional medicines, it has been utilized to reduce stress and anxiety promote sleep. A growing body clinical evidence suggests that MO leaf extract supplementation possesses considerable neuropharmacological properties. However, its possible mechanism action largely remains unknown. Objective: present in vitro studies, we comparatively investigated central nervous system (CNS)-calming antioxidative properties an innovative standardized phospholipid carrier-based (Phytosome™) (Relissa™) vs. unformulated dry extract. Methods: The effect was studied anti-depressant enzymes γ-aminobutyrate transaminase (GABA-T) monoamine oxidase (MAO-A) assays SH-SY5Y cells brain-derived neurotrophic factor (BDNF) expression assay. neuroprotective against oxidative assessed cell-based (H 2 O -exposed) Total Antioxidant Status (TAS) Reactive Oxygen Species (ROS) assays. cytotoxic evaluated using MTT LDH antioxidant also cell-free chemical tests, including TEAC-ABTS, DPPH, Ferric Reducing Power (FRAP), Radical Capacity (ORAC), Hydroxyl (HORAC) Results: Relissa™ exhibited high GABA-T inhibitory activity, IC 50 (mg/mL) = 0.064 extract, 0.27. Similar effects were observed for MAO-A. demonstrated improved on H -induced stress. Compared exerted protective -exposed cells, leading higher BDNF levels. Moreover, DPPH radical scavenging, FRAP, ORAC, HORAC assays, validated Conclusion: results study support neuromodulating Relissa™, may help amelioration emotional distress related conditions.

Язык: Английский

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Internalized HIV Stigma, Sleep Problems, and Depressive Symptoms in People with HIV in Botswana

Behavioral Medicine, Год журнала: 2025, Номер unknown, С. 1 - 5

Опубликована: Янв. 20, 2025

This study investigates the impact of internalized HIV stigma on sleep problems and depression in people living with (PLWH) Botswana. It also explores whether mediate relationship between depressive symptoms, given that disturbance is a symptom often predates episode. Secondary analysis was conducted using baseline data from pilot randomized controlled trial 58 virally unsuppressed PLWH Gaborone, Internalized stigma, daytime impairment, symptoms were assessed validated scales. Multiple linear regression simple mediation models bootstrap procedures employed. Covariates for adjusted age sex assigned at birth. One five participants reported experiencing moderate to extreme problems. associated greater nighttime disturbance, but not impairments or symptoms. An indirect effect via identified; however, this path no longer significant after adjusting covariates. No effects found impairments. The findings extend existing literature by exploring interplay disturbances, among Africa. While contributes its role affecting less clear, potentially due small sample size. suggests need targeted interventions addressing disturbances mitigate psychological impacts stigma.

Язык: Английский

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