The Role of Sleep in Cardiovascular Disease

Current Atherosclerosis Reports, Journal Year: 2024, Volume and Issue: 26(7), P. 249 - 262

Published: May 25, 2024

Sleep is an important component of cardiovascular (CV) health. This review summarizes the complex relationship between sleep and CV disease (CVD). Additionally, we describe data supporting treatment disturbances in preventing treating CVD.

Language: Английский

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Social network site addiction, sleep quality, depression and adolescent difficulty describing feelings: a moderated mediation model

BMC Psychology, Journal Year: 2025, Volume and Issue: 13(1)

Published: Jan. 20, 2025

Language: Английский

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Mechanisms, consequences and role of interventions for sleep deprivation: Focus on mild cognitive impairment and Alzheimer’s disease in elderly

Ageing Research Reviews, Journal Year: 2024, Volume and Issue: 100, P. 102457 - 102457

Published: Aug. 17, 2024

Language: Английский

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Melanin-concentrating hormone: A promising target for antidepressant treatment

Pharmacology Biochemistry and Behavior, Journal Year: 2025, Volume and Issue: 250, P. 173999 - 173999

Published: March 11, 2025

Language: Английский

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Scn1a haploinsufficiency in the prefrontal cortex engages to cognitive impairment and depressive phenotype

Brain, Journal Year: 2024, Volume and Issue: unknown

Published: May 21, 2024

Abstract Altered development and function of the prefrontal cortex (PFC) during adolescence is implicated in origin mental disorders. Deficits GABAergic system prominently contribute to these alterations. Nav1.1 a voltage-gated Na+ channel critical for normal activity. Here, we studied role PFC its potential relationship with aetiology Dysfunction activity medial (mPFC) adolescent mice enhanced local excitation/inhibition ratio, resulting epileptic activity, cognitive deficits depressive-like behaviour adulthood, along gene expression profile linked major depressive disorder (MDD). Additionally, it reduced extracellular serotonin concentration dorsal raphe nucleus brain-derived neurotrophic factor hippocampus, two MDD-related brain areas beyond PFC. We also observed alterations oscillatory impaired hippocampal-mPFC coherence sleep. Finally, found levels SCN1A, encoding Nav1.1, post-mortem samples from human MDD subjects. Collectively, our results provide novel mechanistic framework linking adolescence-specific pathogenesis epilepsy comorbidities such as impairment

Language: Английский

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Hypersomnia as a predictor of response to intravenous ketamine/intranasal esketamine in treatment resistant depression

Journal of Affective Disorders, Journal Year: 2024, Volume and Issue: 349, P. 272 - 276

Published: Jan. 8, 2024

Language: Английский

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Internalized HIV Stigma, Sleep Problems, and Depressive Symptoms in People with HIV in Botswana

Behavioral Medicine, Journal Year: 2025, Volume and Issue: unknown, P. 1 - 5

Published: Jan. 20, 2025

This study investigates the impact of internalized HIV stigma on sleep problems and depression in people living with (PLWH) Botswana. It also explores whether mediate relationship between depressive symptoms, given that disturbance is a symptom often predates episode. Secondary analysis was conducted using baseline data from pilot randomized controlled trial 58 virally unsuppressed PLWH Gaborone, Internalized stigma, daytime impairment, symptoms were assessed validated scales. Multiple linear regression simple mediation models bootstrap procedures employed. Covariates for adjusted age sex assigned at birth. One five participants reported experiencing moderate to extreme problems. associated greater nighttime disturbance, but not impairments or symptoms. An indirect effect via identified; however, this path no longer significant after adjusting covariates. No effects found impairments. The findings extend existing literature by exploring interplay disturbances, among Africa. While contributes its role affecting less clear, potentially due small sample size. suggests need targeted interventions addressing disturbances mitigate psychological impacts stigma.

Language: Английский

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Smart home-assisted anomaly detection system for older adults: a deep learning approach with a comprehensive set of daily activities

Medical & Biological Engineering & Computing, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 31, 2025

Language: Английский

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Association between sleep duration and depression in adolescents and young adults: a system review of observational studies and a genetic research of Mendelian randomization analysis

Postgraduate Medical Journal, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 26, 2025

This study aimed to explore the causal association between sleep duration and depression in adolescents young adults. We conducted a systematic review Mendelian randomization (MR) research relationship short adolescent risk from an observational genetic perspective. In review, we searched studies PubMed, Embase, Cochrane Library databases. MR analysis part, screened Single Nucleotide Polymorphism (SNP) significantly relative conforming concept investigate causality. All evidence shows that who <6 h have highest rates of depression. According result, affected (odds ratio, 1.034; 95% confidence interval, 1.012-1.058, P = .003). Sleep 7-8 has lowest incidence. Insufficient (≤6 h) excessive (≥8 also elevates risk. Genetic (<6 significant effects on was causally associated with or >8 daily increases

Language: Английский

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Mental Health and Lifestyle Factors Among Higher Education Students: A Cross-Sectional Study

Behavioral Sciences, Journal Year: 2025, Volume and Issue: 15(3), P. 253 - 253

Published: Feb. 23, 2025

This study aimed to describe the lifestyle factors and mental health levels among higher education students identify their predictors. A cross-sectional with a sample of 745 was conducted from Polytechnic Porto using Depression Anxiety Stress Scales (DASS-21), Clinical Outcomes in Routine Evaluation (CORE)-18, FANTASTICO Lifestyle Questionnaire. The findings indicate that while generally exhibited positive lifestyle, they also experienced mild depression, anxiety, stress, nearing moderate threshold. DASS-21 subscale significant predictor both CORE-18 scores, underscoring strong relationship between depression overall well-being. stress were predictors reflecting negative impact on students’ psychological Perceived status male sex associated better outcomes CORE-18, female predicted healthier as measured by FANTASTICO. These highlight importance targeted interventions address promote healthy choices educational settings.

Language: Английский

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