Chronic sleep deprivation exacerbates cognitive and synaptic plasticity impairments in APP/PS1 transgenic mice

Behavioural Brain Research, Год журнала: 2021, Номер 412, С. 113400 - 113400

Опубликована: Июнь 7, 2021

Язык: Английский

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The role of orexin in Alzheimer disease: From sleep-wake disturbance to therapeutic target

Neuroscience Letters, Год журнала: 2021, Номер 765, С. 136247 - 136247

Опубликована: Сен. 14, 2021

Язык: Английский

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Electroacupuncture Enhances Neuroplasticity by Regulating the Orexin A-Mediated cAMP/PKA/CREB Signaling Pathway in Senescence-Accelerated Mouse Prone 8 (SAMP8) Mice

Oxidative Medicine and Cellular Longevity, Год журнала: 2022, Номер 2022, С. 1 - 15

Опубликована: Фев. 4, 2022

Learning and memory disorders decreased neuroplasticity are the main clinical manifestations of age-induced cognitive dysfunction. Orexin A (OxA) has been reported to show abnormally elevated expression in cerebrospinal fluid (CSF) patients with Alzheimer's disease (AD) be associated impairment. Here, we further assessed whether excitatory neurotransmitter OxA is involved function senescence-accelerated mouse prone 8 (SAMP8) mice. In this study, investigated mechanism by using behavioral tests, CSF microdialysis, immunofluorescence, toluidine blue staining, gene silencing, transmission electron microscopy, Western blotting. The results showed that 10 Hz electroacupuncture (EA) effectively alleviated learning impairment 7-month-old SAMP8 mice, reduced levels CSF, increased level glutamate, pathological damage hippocampal tissue, improved synaptic structure, enhanced transmission, regulated cAMP/PKA/CREB signaling pathway-related proteins. These suggest EA enhances mice regulating OxA-mediated pathway, thus improving function. findings may beneficial for prevention treatment

Язык: Английский

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Orexin-A aggravates cognitive deficits in 3xTg-AD mice by exacerbating synaptic plasticity impairment and affecting amyloid β metabolism

Neurobiology of Aging, Год журнала: 2023, Номер 124, С. 71 - 84

Опубликована: Янв. 18, 2023

Язык: Английский

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Sleep, neuronal hyperexcitability, inflammation and neurodegeneration: Does early chronic short sleep trigger and is it the key to overcoming Alzheimer’s disease?

Neuroscience & Biobehavioral Reviews, Год журнала: 2021, Номер 129, С. 157 - 179

Опубликована: Июнь 29, 2021

Язык: Английский

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