Sleep, neuronal hyperexcitability, inflammation and neurodegeneration: Does early chronic short sleep trigger and is it the key to overcoming Alzheimer’s disease? DOI
A. Ahnaou, Wilhelmus Drinkenburg

Neuroscience & Biobehavioral Reviews, Journal Year: 2021, Volume and Issue: 129, P. 157 - 179

Published: June 29, 2021

Language: Английский

Chronic sleep deprivation exacerbates cognitive and synaptic plasticity impairments in APP/PS1 transgenic mice DOI
Chun Wang,

Wen-Rui Gao,

Jing Yin

et al.

Behavioural Brain Research, Journal Year: 2021, Volume and Issue: 412, P. 113400 - 113400

Published: June 7, 2021

Language: Английский

Citations

22
The role of orexin in Alzheimer disease: From sleep-wake disturbance to therapeutic target DOI
Fan Gao, Tao Liu,

Miao Tuo

et al.

Neuroscience Letters, Journal Year: 2021, Volume and Issue: 765, P. 136247 - 136247

Published: Sept. 14, 2021

Language: Английский

Citations

22
Electroacupuncture Enhances Neuroplasticity by Regulating the Orexin A-Mediated cAMP/PKA/CREB Signaling Pathway in Senescence-Accelerated Mouse Prone 8 (SAMP8) Mice DOI Creative Commons
Zhitao Hou, Xinyu Yang, Yang Li

et al.

Oxidative Medicine and Cellular Longevity, Journal Year: 2022, Volume and Issue: 2022, P. 1 - 15

Published: Feb. 4, 2022

Learning and memory disorders decreased neuroplasticity are the main clinical manifestations of age-induced cognitive dysfunction. Orexin A (OxA) has been reported to show abnormally elevated expression in cerebrospinal fluid (CSF) patients with Alzheimer's disease (AD) be associated impairment. Here, we further assessed whether excitatory neurotransmitter OxA is involved function senescence-accelerated mouse prone 8 (SAMP8) mice. In this study, investigated mechanism by using behavioral tests, CSF microdialysis, immunofluorescence, toluidine blue staining, gene silencing, transmission electron microscopy, Western blotting. The results showed that 10 Hz electroacupuncture (EA) effectively alleviated learning impairment 7-month-old SAMP8 mice, reduced levels CSF, increased level glutamate, pathological damage hippocampal tissue, improved synaptic structure, enhanced transmission, regulated cAMP/PKA/CREB signaling pathway-related proteins. These suggest EA enhances mice regulating OxA-mediated pathway, thus improving function. findings may beneficial for prevention treatment

Language: Английский

Citations

16
Orexin-A aggravates cognitive deficits in 3xTg-AD mice by exacerbating synaptic plasticity impairment and affecting amyloid β metabolism DOI
Yiying Li,

Kai-Yue Yu,

Yujia Cui

et al.

Neurobiology of Aging, Journal Year: 2023, Volume and Issue: 124, P. 71 - 84

Published: Jan. 18, 2023

Language: Английский

Citations

8
Sleep, neuronal hyperexcitability, inflammation and neurodegeneration: Does early chronic short sleep trigger and is it the key to overcoming Alzheimer’s disease? DOI
A. Ahnaou, Wilhelmus Drinkenburg

Neuroscience & Biobehavioral Reviews, Journal Year: 2021, Volume and Issue: 129, P. 157 - 179

Published: June 29, 2021

Language: Английский

Citations

18