Verbal semantic expertise is associated with reduced functional connectivity between left and right anterior temporal lobes

Cerebral Cortex, Год журнала: 2024, Номер 34(6)

Опубликована: Июнь 1, 2024

Abstract The left and right anterior temporal lobes (ATLs) encode semantic representations. They show graded hemispheric specialization in function, with the ATL contributing preferentially to verbal processing. We investigated cognitive correlates of this organization, using resting-state functional connectivity as a measure segregation between ATLs. analyzed two independent fMRI datasets (n = 86 n 642) which participants’ expertise was measured vocabulary tests. In both datasets, people more advanced knowledge showed weaker ventral This effect highly specific. It not observed for within-hemisphere connections regions (ventral inferior frontal gyrus (IFG), though it found left–right IFG one dataset). Effects were tasks probing control, nonsemantic cognition, or face recognition. Our results suggest that ATLs is an innate property but rather emerges develop detailed speculate consequence ATL’s greater left-lateralized written word recognition regions, causes represent meaning acquired primarily through reading.

Язык: Английский

Functional integration and segregation during semantic cognition: Evidence across age groups

Cortex, Год журнала: 2024, Номер 178, С. 157 - 173

Опубликована: Июль 9, 2024

Semantic cognition is underpinned by ventral anterior temporal lobe (vATL) which encodes knowledge representations and inferior frontal gyrus (IFG), controls activation of based on the needs current context. This core semantic network has been validated in substantial empirical findings past. However, it remains unclear how these areas dynamically communicate with each other, other neural networks, to achieve successful processing. Here, we investigated this question testing functional connectivity during tasks whether connections were affected cognitive ageing. Compared a non-semantic task, increased between left right IFGs, indicating bilateral control system. Strengthened was also found IFG vATL, effect stronger young group. At whole-brain scale, vATL their coupling multiple-demand regions tasks, even though deactivated relative tasks. suggests that domain-general executive contributes In contrast, decreased interaction default mode (DMN) positively activated task. DMN do not contribute all tasks: may sometimes reflect automatic retrieval task-irrelevant memories associations. Taken together, our study characterizes dynamic mechanism supporting within beyond regions.

Язык: Английский

Midlife Dynamics of White Matter Architecture in Lexical Production

Neurobiology of Aging, Год журнала: 2024, Номер 144, С. 138 - 152

Опубликована: Сен. 28, 2024

Язык: Английский