Cortex,
Journal Year:
2024,
Volume and Issue:
178, P. 157 - 173
Published: July 9, 2024
Semantic
cognition
is
underpinned
by
ventral
anterior
temporal
lobe
(vATL)
which
encodes
knowledge
representations
and
inferior
frontal
gyrus
(IFG),
controls
activation
of
based
on
the
needs
current
context.
This
core
semantic
network
has
been
validated
in
substantial
empirical
findings
past.
However,
it
remains
unclear
how
these
areas
dynamically
communicate
with
each
other,
other
neural
networks,
to
achieve
successful
processing.
Here,
we
investigated
this
question
testing
functional
connectivity
during
tasks
whether
connections
were
affected
cognitive
ageing.
Compared
a
non-semantic
task,
increased
between
left
right
IFGs,
indicating
bilateral
control
system.
Strengthened
was
also
found
IFG
vATL,
effect
stronger
young
group.
At
whole-brain
scale,
vATL
their
coupling
multiple-demand
regions
tasks,
even
though
deactivated
relative
tasks.
suggests
that
domain-general
executive
contributes
In
contrast,
decreased
interaction
default
mode
(DMN)
positively
activated
task.
DMN
do
not
contribute
all
tasks:
may
sometimes
reflect
automatic
retrieval
task-irrelevant
memories
associations.
Taken
together,
our
study
characterizes
dynamic
mechanism
supporting
within
beyond
regions.
bioRxiv (Cold Spring Harbor Laboratory),
Journal Year:
2023,
Volume and Issue:
unknown
Published: Oct. 17, 2023
Abstract
Semantic
knowledge
includes
understanding
of
objects
and
their
features
also
the
characteristics
events.
The
hub-and-spoke
theory
holds
that
these
conceptual
representations
rely
on
multiple
information
sources
are
integrated
in
a
central
hub
ventral
anterior
temporal
lobes
(vATL).
Dual-hub
expands
this
framework
with
claim
vATL
is
specialized
for
object
representation,
while
second
angular
gyrus
(AG)
event
representation.
To
test
ideas,
we
used
RSA,
univariate
PPI
analyses
fMRI
data
collected
participants
processed
concepts
(e.g.,
‘an
apple’,
‘a
wedding’)
presented
as
images
written
words.
RSA
showed
AG
encoded
concept
similarity
more
than
similarity,
although
left
similarity.
Bilateral
vATLs
both
structure,
exhibited
stronger
coding
analysis
revealed
greater
connectivity
between
right
pMTG,
bilateral
ITG
middle
occipital
gyrus,
compared
to
concepts.
These
findings
support
specialization
semantics,
though
some
involvement
coding,
but
do
not
Cerebral Cortex,
Journal Year:
2024,
Volume and Issue:
34(6)
Published: June 1, 2024
Abstract
The
left
and
right
anterior
temporal
lobes
(ATLs)
encode
semantic
representations.
They
show
graded
hemispheric
specialization
in
function,
with
the
ATL
contributing
preferentially
to
verbal
processing.
We
investigated
cognitive
correlates
of
this
organization,
using
resting-state
functional
connectivity
as
a
measure
segregation
between
ATLs.
analyzed
two
independent
fMRI
datasets
(n
=
86
n
642)
which
participants’
expertise
was
measured
vocabulary
tests.
In
both
datasets,
people
more
advanced
knowledge
showed
weaker
ventral
This
effect
highly
specific.
It
not
observed
for
within-hemisphere
connections
regions
(ventral
inferior
frontal
gyrus
(IFG),
though
it
found
left–right
IFG
one
dataset).
Effects
were
tasks
probing
control,
nonsemantic
cognition,
or
face
recognition.
Our
results
suggest
that
ATLs
is
an
innate
property
but
rather
emerges
develop
detailed
speculate
consequence
ATL’s
greater
left-lateralized
written
word
recognition
regions,
causes
represent
meaning
acquired
primarily
through
reading.
Cortex,
Journal Year:
2024,
Volume and Issue:
178, P. 157 - 173
Published: July 9, 2024
Semantic
cognition
is
underpinned
by
ventral
anterior
temporal
lobe
(vATL)
which
encodes
knowledge
representations
and
inferior
frontal
gyrus
(IFG),
controls
activation
of
based
on
the
needs
current
context.
This
core
semantic
network
has
been
validated
in
substantial
empirical
findings
past.
However,
it
remains
unclear
how
these
areas
dynamically
communicate
with
each
other,
other
neural
networks,
to
achieve
successful
processing.
Here,
we
investigated
this
question
testing
functional
connectivity
during
tasks
whether
connections
were
affected
cognitive
ageing.
Compared
a
non-semantic
task,
increased
between
left
right
IFGs,
indicating
bilateral
control
system.
Strengthened
was
also
found
IFG
vATL,
effect
stronger
young
group.
At
whole-brain
scale,
vATL
their
coupling
multiple-demand
regions
tasks,
even
though
deactivated
relative
tasks.
suggests
that
domain-general
executive
contributes
In
contrast,
decreased
interaction
default
mode
(DMN)
positively
activated
task.
DMN
do
not
contribute
all
tasks:
may
sometimes
reflect
automatic
retrieval
task-irrelevant
memories
associations.
Taken
together,
our
study
characterizes
dynamic
mechanism
supporting
within
beyond
regions.
