Advances and challenges in precision imaging

The Lancet Oncology, Год журнала: 2025, Номер 26(1), С. e34 - e45

Опубликована: Янв. 1, 2025

Язык: Английский

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Deuterium metabolic imaging of the human brain in vivo at 7 T

Magnetic Resonance in Medicine, Год журнала: 2022, Номер 89(1), С. 29 - 39

Опубликована: Сен. 5, 2022

Purpose To explore the potential of deuterium metabolic imaging (DMI) in human brain vivo at 7 T, using a multi‐element ( 2 H) RF coil for 3D volume coverage. Methods 1 H‐MR images and localized H MR spectra were acquired 3 healthy subjects to generate DMI maps H‐labeled water, glucose, glutamate/glutamine (Glx). In addition, non‐localized both vitro determine T relaxation times deuterated metabolites T. The performance was assessed through numeric simulations experimentally B + maps. Results covering entire obtained from well‐resolved metabolite resonances Glx. consistent with those reported adjacent field strengths. Experimental good agreement simulations, indicating efficient homogeneous transmission low power deposition H, similar array design 9.4 Conclusion Here, we have demonstrated successful implementation spatial temporal nominal resolutions achieved (i.e., 2.7 mL 28 min, respectively) close greatly outperformed lower magnetic fields. beyond has clear applications dealing small lesions.

Язык: Английский

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Metabolic imaging with deuterium labeled substrates

Progress in Nuclear Magnetic Resonance Spectroscopy, Год журнала: 2023, Номер 134-135, С. 39 - 51

Опубликована: Фев. 10, 2023

Deuterium metabolic imaging (DMI) is an emerging clinically-applicable technique for the non-invasive investigation of tissue metabolism. The generally short T1 values 2H-labeled metabolites in vivo can compensate relatively low sensitivity detection by allowing rapid signal acquisition absence significant saturation. Studies with deuterated substrates, including [6,6′-2H2]glucose, [2H3]acetate, [2H9]choline and [2,3-2H2]fumarate have demonstrated considerable potential DMI metabolism cell death vivo. evaluated here comparison established techniques, PET measurements 2-deoxy-2-[18F]fluoro-d-glucose (FDG) uptake 13C MR hyperpolarized 13C-labeled substrates.

Язык: Английский

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Current methods for hyperpolarized [1‐¹³C]pyruvate MRI human studies

Magnetic Resonance in Medicine, Год журнала: 2024, Номер 91(6), С. 2204 - 2228

Опубликована: Март 5, 2024

Abstract MRI with hyperpolarized (HP) 13 C agents, also known as HP MRI, can measure processes such localized metabolism that is altered in numerous cancers, liver, heart, kidney diseases, and more. It has been translated into human studies during the past 10 years, recent rapid growth largely based on increasing availability of agent preparation methods suitable for use humans. This paper aims to capture current successful practices [1‐ C]pyruvate—by far most commonly used agent, which sits at a key metabolic junction glycolysis. The divided four major topic areas: (1) C‐pyruvate preparation; (2) system setup calibrations; (3) data acquisition image reconstruction; (4) analysis quantification. In each area, we identified components study, summarized both published practices, discuss evidence gaps, strengths, limitations. output “HP Consensus Group” well ISMRM Hyperpolarized Media MR Methods Equipment study groups. further provide comprehensive reference future consensus, building field continues advance this imaging modality.

Язык: Английский

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Mapping of exogenous choline uptake and metabolism in rat glioblastoma using deuterium metabolic imaging (DMI)

Frontiers in Cellular Neuroscience, Год журнала: 2023, Номер 17

Опубликована: Апрель 28, 2023

Introduction There is a lack of robust metabolic imaging techniques that can be routinely applied to characterize lesions in patients with brain tumors. Here we explore an animal model glioblastoma the feasibility detect uptake and metabolism deuterated choline describe tumor-to-brain image contrast. Methods RG2 cells were incubated level intracellular its metabolites measured cell extracts using high resolution 1 H NMR. In rats orthotopically implanted tumors deuterium (DMI) was vivo during, as well day after, intravenous infusion 2 9 -choline. parallel experiments, RG2-bearing infused [1,1′,2,2′- 4 ]-choline tissue metabolite analyzed NMR identify molecule-specific H-labeling metabolites. Results vitro experiments indicated fast phosphorylation exogenous cells. DMI studies revealed signal from H-labeled pool + (total choline, H-tCho) tumor lesion but not normal brain. Quantitative DMI-based maps H-tCho showed contrast acquired both 24 h after infusion. High data during H-choline consists free phosphocholine, while later represent phosphocholine glycerophosphocholine. Discussion Uptake compared brain, resulting on maps. By varying timing acquisition relative start infusion, weighted toward detection or metabolism. These proof-of-principle highlight potential combined metabolically

Язык: Английский

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Deuterated Nanopolymers for Renal and Lymphatic Imaging via Quantitative Deuterium MRI

Nano Letters, Год журнала: 2025, Номер unknown

Опубликована: Янв. 22, 2025

Deuterium (2H) MRI is an emerging tool for noninvasive imaging. We explore the integration of 2H with deuterated multifunctional nanopolymers particle imaging (DPI). To this end, amine-terminated G5-polyamidoamine (PAMAM) dendrimers were labeled acetyl surface groups, leading to highly 2H-loaded bioparticles, making them ideal studies. The accumulation ∼5 nm PAMAM in kidneys could then be seen by high submillimeter resolution. natural abundance HDO signal provided internal concentration reference these measurements, quantitative dynamic maps showing distinct nanopolymer uptakes within renal compartments. Further, allowed us obtain vivo activity lymph nodes inflammatory rodent leg model, demonstrating nanopolymers' potential as a novel class contrast agents mapping physiological processes.

Язык: Английский

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Deuterium Metabolic Imaging of the Human Abdomen at Clinical Field Strength

Investigative Radiology, Год журнала: 2025, Номер unknown

Опубликована: Март 14, 2025

Objectives The aim of the study was to translate abdominal deuterium metabolic imaging (DMI) clinical field strength by optimizing radiofrequency coil setup, administered dose ( 2 H)-labeled glucose, and data processing pipeline for quantitative characterization DMI signals over time. This assessed in kidney liver establish a basis routine studies future. Materials Methods 5 healthy volunteers were recruited imaged on or 3 separate occasions, with varying doses H-glucose: 0.75 g/kg (high dose), 0.50 (medium 0.25 (low resulting total 13 scan sessions. performed at T using flexible 20 × 30 cm H-tuned transmit-receive surface coil. For comparisons across scans, H-glucose signal normalized against sum H-water (GGW ratio). To quantify time course GGW, novel metrics metabolism defined compared between organs: maximum value max ), whole AUC average plateau mean ). H-lipid overlaps H-lactate; hence, measured as combined H-lipid+lactate signal. Results careful positioning dedicated minimized unwanted gastric while maintaining excellent hepatic renal measurements. courses derived from reproducible comparable different doses, showing potential reduction. plateaued approximately minutes, that 40 minutes. exhibited higher values uptake kidney, trend consistent all example, highest dose: GGW = 31 ± 3; 27 P 0.05. A toward lower measurements decreasing observed: this significant high low parameters medium , but not any parameters. increased 70–90 minutes 12/13 cases (mean: 39 24%), lipid+lactate only 8/13 17%). 18 10%), 10/13 10 13%). Conclusions human abdomen is feasible magnetic resonance system changes can serve reference future studies. be reduced minimize without substantially affecting reliability organ quantification. increase could direct indirect measures metabolism, respectively.

Язык: Английский

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Deuterium metabolic imaging for 3D mapping of glucose metabolism in humans with central nervous system lesions at 3T

Magnetic Resonance in Medicine, Год журнала: 2023, Номер 91(1), С. 39 - 50

Опубликована: Окт. 5, 2023

Abstract Purpose To explore the potential of 3T deuterium metabolic imaging (DMI) using a birdcage 2 H radiofrequency (RF) coil in both healthy volunteers and patients with central nervous system (CNS) lesions. Methods A modified gradient filter, home‐built volume RF coil, spherical k‐space sampling were employed three‐dimensional chemical shift acquisition to obtain high‐quality whole‐brain images H‐labeled water glucose products. These acquired volunteer three subjects CNS lesions varying pathologies. Hardware pulse sequence experiments also conducted improve signal‐to‐noise ratio DMI at 3T. Results The ability quantify local metabolism correspondence anatomical landmarks across is demonstrated, increased lactate observed one patient most active disease. Conclusion offers examine activity human 3T, promising for future clinical translation this technique.

Язык: Английский

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New Horizons in Hyperpolarized 13C MRI

Molecular Imaging and Biology, Год журнала: 2023, Номер 26(2), С. 222 - 232

Опубликована: Дек. 26, 2023

Abstract Hyperpolarization techniques significantly enhance the sensitivity of magnetic resonance (MR) and thus present fascinating new directions for research applications with in vivo MR imaging spectroscopy (MRI/S). Hyperpolarized 13 C MRI/S, particular, enables real-time non-invasive assessment metabolic processes holds great promise a diverse range clinical spanning fields like oncology, neurology, cardiology, potential improving early diagnosis disease, patient stratification, therapy response assessment. Despite its potential, technical challenges remain achieving translation. This paper provides an overview discussions that took place at international workshop “New Horizons MRI,” March 2023 Bavarian Academy Sciences Humanities, Munich, Germany. The covered developments, as well future directions, topics including polarization (particularly focusing on parahydrogen-based methods), novel probes, considerations related to data acquisition analysis, emerging oncology other fields.

Язык: Английский

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Imaging cancer metabolism using magnetic resonance

npj Imaging, Год журнала: 2024, Номер 2(1)

Опубликована: Янв. 11, 2024

Abstract The challenge in clinical oncology is to select the most appropriate treatment for an individual patient. Transcriptome and metabolite profiling have revealed that tumours can display metabolic subtypes with different therapeutic vulnerabilities 1–4 . Metabolic imaging has potential distinguish these therefore those treatment(s) should be effective. Moreover, since changes tumour metabolism occur early during treatment, also used subsequently detect evidence of response. In this Perspective I briefly review discuss relative advantages disadvantages magnetic resonance using hyperpolarized 13 C- 2 H-labelled substrates.

Язык: Английский

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