Measuring Human Auditory Evoked Fields with a Flexible Multi-Channel OPM-Based MEG System

Journal of Integrative Neuroscience, Год журнала: 2024, Номер 23(5)

Опубликована: Апрель 30, 2024

Background: Magnetoencephalography (MEG) is a non-invasive imaging technique for directly measuring the external magnetic field generated from synchronously activated pyramidal neurons in brain. The optically pumped magnetometer (OPM) known its less expensive, non-cryogenic, movable and user-friendly custom-design provides potential change functional neuroimaging based on MEG. Methods: An array of OPMs covering opposite sides subject’s head placed inside magnetically shielded room (MSR) responses evoked auditory cortices are measured. Results: High signal-to-noise ratio response fields (AEFs) were detected by wearable OPM-MEG system MSR, which flexible helmet was specially designed to minimize sensor-to-head distance, along with set bi-planar coils developed background gradient nulling. Neuronal current sources AEF experiments localized showed highest activities. Performance hybrid magnetometer-magnetoencephalography/electroencephalography (OPM-MEG/EEG) also assessed. Conclusions: multi-channel performs well custom built MSR equipped detects human AEFs helmet. Moreover, similarities differences potentials (AEPs) discussed, while operation sensors conjunction EEG electrodes an encouraging combination exploration OPM-MEG/EEG systems.

Язык: Английский

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Simultaneous whole-head electrophysiological recordings using EEG and OPM-MEG

medRxiv (Cold Spring Harbor Laboratory), Год журнала: 2023, Номер unknown

Опубликована: Окт. 23, 2023

ABSTRACT Electroencephalography (EEG) and magnetoencephalography (MEG) non-invasively measure human brain electrophysiology. They differ in nature; MEG offers better performance (higher spatial precision) whilst EEG (a wearable platform) is more practical. are also complementary, with studies showing that concurrent MEG/EEG provides advantages over either modality alone, consequently clinical guidelines for epilepsy recommend simultaneous acquisition of EEG. In recent years, new instrumentation – optically pumped magnetometers (OPMs) has had a significant impact on MEG, offering improved performance, lifespan compliance, sensors. Nevertheless, the ability to carry out EEG/OPM-MEG remains critical. Here, we investigated whether simultaneous, wearable, whole-head OPM-MEG measurably degrades signal quality modality. We employed two tasks: motor task known modulate beta oscillations, an eyes-open/eyes-closed alpha oscillations. both, characterised EEG/OPM-MEG. Our results show SNR response was very similar, regardless modalities were used individually or concurrently. Likewise, our band recordings demonstrated contrast stable, recording. These combined suggest there no fundamental barriers EEG/OPM-MEG, this technique ripe neuroscientific adoption. This will be particularly important sphere where direct comparison between facilitate interpretation data patients.

Язык: Английский

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Improved non-invasive detection of ictal and interictal epileptiform activity using Optically Pumped Magnetometers

medRxiv (Cold Spring Harbor Laboratory), Год журнала: 2022, Номер unknown

Опубликована: Ноя. 5, 2022

Abstract Magneto- and Electroencephalography (MEG/EEG) are important techniques for the diagnosis pre-surgical evaluation of epilepsy. Yet, in current cryogen-based MEG systems sensors offset from scalp, which limits signal-to-noise ratio (SNR) thereby sensitivity to activity deep structures such as hippocampus. This effect is amplified children, whom adult-sized fixed-helmet typically too big. Moreover, ictal recordings with problematic because limited movement tolerance. Optically Pumped Magnetometers (OPMs) can be placed directly on improving SNR consequently to, localisation accuracy of, epileptiform activity. In addition, recording during seizures becomes feasible these wearable sensors. We aimed demonstrate advantages OPMs a clinical population. Three adults known weak sources interictal discharges (IEDs), along three children focal epilepsy one adult frequent underwent using 12-channel OPM-system 306-channel whole-head system. Performance two was compared terms IED-rate SNR. patient detected IEDs that were not found SQUID-system. spike yield higher OPM data (9.00 versus 6.76), negligible difference SQUID (3.85 3.93; U = -2.86, d -0.14). also case comparable (after accounting unilateral coverage OPMs; 4.47 4.57; -3.81, For (11.03 24.50) (4.39 4.05; 9.53, -0.36) both lower OPMs. patients no either Importantly, wearability enabled seizure hyperkinetic movements seizure. The observed onset semiology agreement previous video- stereo-EEG recordings. Overall, very much those obtained cryogenic system: outperformed SQUIDs four IEDs, yield, or an ability detect observable data. SNRs (slightly) than data, but sizes patients. relatively cheap technology, combination reduced running maintenance costs, means OPM-based could used more widely systems, may become affordable alternative scalp EEG, potential benefits increased spatial accuracy, volume conduction/field spread, sources. Wearable thus provides unprecedented opportunity epilepsy, given its patient-friendliness, we envisage it will only presurgical patients, after first

Язык: Английский

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Students’ view of Quantum Information Technologies, part 3

International Journal of Electronics and Telecommunications, Год журнала: 2024, Номер unknown, С. 509 - 518

Опубликована: Июнь 25, 2024

The article is part of a course on Quantum Information Technologies QIT conducted at the Faculty Electronics and Technology Warsaw University Technology. subject includes publishing workshop exercised by engineering students. How do ICT engineers see from their point view? can they implement quantum technologies in future work? M.Sc. students usually have strictly declared topics for master’s theses. implementation some works an advanced stage. potential areas application are defined narrow if to intellectually expand area completed This idea incorporating components or interfaces into classic solutions software hardware level. It possible propose solution form functional hybrid system. systems should be functionally incorporated existing environment, generating measurable added value. Such task quite demanding, but practice shows that it interests Solutions don’t mature even feasible. They dreams young engineers. exercise publication related fast development QIT. continuation exercises with previous groups participating lectures.

Язык: Английский

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Miniaturized Brain Imaging Apparatus Employing Light, Sound, and Magnetic Fields

Опубликована: Янв. 1, 2024

Язык: Английский

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