Biological Psychiatry Cognitive Neuroscience and Neuroimaging, Год журнала: 2022, Номер 7(9), С. 849 - 851
Опубликована: Сен. 1, 2022
Язык: Английский
Cephalalgia, Год журнала: 2023, Номер 43(10)
Опубликована: Окт. 1, 2023
It is unclear whether cortical hyperexcitability in chronic migraine with medication overuse headache (CM-MOH) due to increased thalamocortical drive or aberrant inhibitory mechanisms.Somatosensory evoked potentials (SSEP) were performed by electrical stimulation of the median nerve (M), ulnar (U) and simultaneous both nerves (MU) 27 patients CM-MOH and, for comparison, 23 healthy volunteers (HVs) a comparable age distribution. We calculated degree lateral inhibition using formula: 100 - [MU/(M + U) × 100] level activation analyzing high frequency oscillations (HFOs) embedded parietal N20 SSEPs.Compared HV, showed higher (CM-MOH 52.2% ± 15.4 vs. HV 40.4% 13.3; p = 0.005), which positively correlated monthly days, greater amplitude pre-synaptic HFOs (p 0.010) but normal post-synaptic 0.122).Our findings suggest that central neuronal circuits are highly sensitized patients, at levels. The observed changes could be combination dysfunctional pain control mechanisms, hypersensitivity hyperresponsiveness directly linked intake acute drugs.
Язык: Английский
Процитировано
8
Journal of Psychopharmacology, Год журнала: 2023, Номер 38(1), С. 49 - 55
Опубликована: Ноя. 10, 2023
Cannabis and classic psychedelics are controlled substances with emerging evidence of efficacy in the treatment a variety psychiatric illnesses. has largely not been regarded as having psychedelic effects contemporary literature, despite many examples historical use along to attain altered states consciousness. Research into “psychedelic” cannabis, delta-9-tetrahydrocannabinol (THC) particular, could prove helpful for assessing potential therapeutic indications elucidating mechanism action both cannabis psychedelics. This review aggregates evaluates literature capacity yield perceptual changes, aversiveness, mystical experiences more typically associated such psilocybin. also provides brief contrast neuroimaging findings acute The available suggests that high-THC may be able elicit effects, but these have observed recent research studies due doses, set, settings commonly used. is needed investigate high doses THC context utilized aimed occasion and/or experiences. If can reliably generate under conditions, dose treatments should explored adjunctive disorders considered an active comparator clinical trials involving traditional medications.
Язык: Английский
Процитировано
8
American Journal of Neuroradiology, Год журнала: 2024, Номер 45(7), С. 833 - 840
Опубликована: Фев. 15, 2024
The neurobiological mechanisms underpinning psychiatric disorders such as treatment-resistant major depression, post-traumatic stress disorder, and substance use disorders, remain unknown. Psychedelic compounds, psilocybin, lysergic acid diethylamide, N,N-dimethyltryptamine, have emerged potential therapies for these because of their hypothesized ability to induce neuroplastic effects alter functional networks in the brain. Yet, treatment response obscure. Quantitative neuroimaging is uniquely positioned provide insight into emerging quantify patient response. This review aims synthesize our current state-of-the-art understanding changes occurring brain following or N,N-dimethyltryptamine administration human participants with fMRI PET. We further aim disseminate psychedelic compounds they relate goal improved diagnostics neuropsychiatric illness.
Язык: Английский
Процитировано
1
European Neuropsychopharmacology, Год журнала: 2024, Номер 85, С. 10 - 20
Опубликована: Апрель 21, 2024
Psychedelics like LSD (Lysergic acid diethylamide) and psilocybin are known to modulate perceptual modalities due the activation of mostly serotonin receptors in specific cortical (e.g., visual cortex) subcortical thalamus) regions brain. In domain, these psychedelic modulations often result peculiar disturbances viewed objects light sometimes even hallucinations non-existent environments, objects, creatures. Although underlying processes poorly understood, research conducted over past twenty years on subjective experience psychedelics details theories that attempt explain alterations a disruption communication between regions. However, rare medical conditions system Charles Bonnet syndrome cause distortions may shed new additional importance retinofugal pathway experiences. Interneurons retina called amacrine cells could be first site modulation aid disrupting hierarchical structure how humans perceive information. This paper presents an understanding communicates modulates information clinical conditions. Therefore, we elucidate theory pathway.
Язык: Английский
Процитировано
1
Psychedelic Medicine, Год журнала: 2024, Номер 2(2), С. 109 - 115
Опубликована: Фев. 28, 2024
Psilocybin is a psychedelic drug with potential therapeutic effects in patients mood and substance use disorders. Little known about its impact on the immune system. Multiplex immunoassay pro-inflammatory cytokine panels (Meso-Scale Discovery, Rockville, MD) were used to examine serum from participants three separate randomized controlled clinical trials (randomized [RCTs]) wherein range of doses psilocybin administered (methods reported previously). Participants represented histories including those no-known health problems/long-term meditation practice (n = 35), depression 25), anxiety, cancer (various types; n 31). Linear mixed models random for each participant fit determine relative levels both immediately before at various time points after administration, adjusted multiple comparisons. Serum extracted during waitlist, where applicable, was not included. Sera 91 included our prior RCTs. In linear pooled data, sera collected ≤1-week postpsilocybin revealed increased interleukin (IL)-8 (β 0.164, 95% confidence interval [0.10 0.23]; p 0.042). At ≥4-week compared baseline, there no changes levels. individual studies, point observed. This preliminary study suggests that transient increase production may be found, although consistently across patient populations. More broadly, peripheral possibly altered by administration. ClinicalTrials.gov Identifier: NCT01988311.
Язык: Английский
Процитировано
0
Опубликована: Май 28, 2024
Serotonergic psychedelic drugs have shown promising benefits in trials for various neuropsychiatric disorders. While the acute effects of these psychedelics last only a few hours, positive therapeutic can persist long after single administration. produce their by activating serotonin 2A receptors, but they differ other pharmacological aspects. To guide safest and most effective treatment specific disorders, it is crucial to gain better understanding distinct long-term on living brain. Here we demonstrate how three different serotonergic psychedelics; psilocybin, LSD 2C-B, induce patterns rat brain metabolic activity connectivity. The doses administered were chosen reflect humans. We found that, psilocybin induced pattern effects, particularly focusing changes connectivity between cortical regions such as orbitofrontal, medial prefrontal, insula cortex, well with dorsal striatum, thalamus, hippocampus. In contrast, 2C-B showed more similar impacts centered inhibition anterior cingulate cortex. This was accompanied increased amygdala hypothalamus, along heightened dopamine cell-rich ventral tegmental area substantia nigra. Our findings within networks provide new insights into shared drug-selective mechanisms underlying substances These could offer guidance which might be beneficial certain psychiatric diseases.
Язык: Английский
Процитировано
0
Опубликована: Окт. 2, 2024
The pulvinar, the largest nucleus in human thalamus, is a complex, highly interconnected structure. Through dense, organized network of cortical and subcortical areas, it provides adequate cooperation between neural systems, which crucial for multiple high-order functions such as perception, visuospatial attention, emotional processing. Such central role made possible by precise internal topographical organization, mirrored anatomical connections well expression neurochemical markers. While being traditionally subdivided into sub-nuclei, each characterized distinct connectional morphological features, recent studies both primate brains have highlighted that this organization only marginally aligns with conventional histological subdivision. Instead, has been delineated context continuous gradients along dorsoventral mediolateral axes. multi-gradient extensively documented models, remains relatively underexplored brain. present work combines high-quality, multi-modal structural functional imaging data recently published whole-brain, large-scale, positron emission tomography (PET) atlas detailing 19 neurotransmitters receptors distributed across By applying diffusion embedding analysis to tractography, connectivity, receptor coexpression data, we identify characterize topographically connections, coactivation, molecular binding patterns. We demonstrate converge on shared representation axes pulvinar. This transitions spanning from lower-level higher-order regions. Moreover, paralleled gradual changes markers associated key neuromodulator including serotoninergic, noradrenergic, dopaminergic, opioid systems. contend our findings mark significant stride towards more comprehensive understanding pulvinar anatomy function, providing nuanced characterization its health disease.
Язык: Английский
Процитировано
0
Опубликована: Окт. 2, 2024
The pulvinar, the largest nucleus in human thalamus, is a complex, highly interconnected structure. Through dense, organized network of cortical and subcortical areas, it provides adequate cooperation between neural systems, which crucial for multiple high-order functions such as perception, visuospatial attention, emotional processing. Such central role made possible by precise internal topographical organization, mirrored anatomical connections well expression neurochemical markers. While being traditionally subdivided into sub-nuclei, each characterized distinct connectional morphological features, recent studies both primate brains have highlighted that this organization only marginally aligns with conventional histological subdivision. Instead, has been delineated context continuous gradients along dorsoventral mediolateral axes. multi-gradient extensively documented models, remains relatively underexplored brain. present work combines high-quality, multi-modal structural functional imaging data recently published whole-brain, large-scale, positron emission tomography (PET) atlas detailing 19 neurotransmitters receptors distributed across By applying diffusion embedding analysis to tractography, connectivity, receptor coexpression data, we identify characterize topographically connections, coactivation, molecular binding patterns. We demonstrate converge on shared representation axes pulvinar. This transitions spanning from lower-level higher-order regions. Moreover, paralleled gradual changes markers associated key neuromodulator including serotoninergic, noradrenergic, dopaminergic, opioid systems. contend our findings mark significant stride towards more comprehensive understanding pulvinar anatomy function, providing nuanced characterization its health disease.
Язык: Английский
Процитировано
0
Brain Imaging and Behavior, Год журнала: 2024, Номер 19(1), С. 23 - 31
Опубликована: Окт. 17, 2024
Язык: Английский
Процитировано
0
bioRxiv (Cold Spring Harbor Laboratory), Год журнала: 2024, Номер unknown
Опубликована: Дек. 15, 2024
Abstract Lysergic acid diethylamide (LSD) is a classic serotonergic psychedelic that induces profoundly altered conscious state. In conjunction with psychological support, it currently being explored as treatment for generalized anxiety disorder and depression. The dorsolateral prefrontal cortex (DLPFC) brain region known to be involved in mood regulation disorders; hypofunction the left DLPFC associated This study investigated role of psycho-emotional effects LSD functional magnetic resonance imaging (fMRI) magnetoencephalography (MEG) data healthy human participants during acute experience. fMRI data, we measured correlation between changes resting-state connectivity (RSFC) post-scan subjective ratings positive mood, emotional arousal, ego dissolution. We found significant, correlations dissolution & right DLPFC, thalamus, higher-order visual area, fusiform face area (FFA). Additionally, arousal was significantly increased intraparietal sulcus (IPS), salience network (SN). A confirmational “reverse” analysis, which outputs original RSFC analysis were used input seeds, substantiated aforementioned regions both arousal. Subsequently, on directed MEG source-localized output reverse analyses. Granger causality (GC) revealed information flow two nodes ‘ego network’, thalamus theta band, substantiating hypothesis disruptions thalamic gating underlie experience Overall, this multimodal elucidates LSD-induced states consciousness sheds more light basis
Язык: Английский
Процитировано
0