Theta activity and cognitive functioning: Integrating evidence from resting-state and task-related developmental electroencephalography (EEG) research

Developmental Cognitive Neuroscience, Год журнала: 2024, Номер 67, С. 101404 - 101404

Опубликована: Июнь 1, 2024

The theta band is one of the most prominent frequency bands in electroencephalography (EEG) power spectrum and presents an interesting paradox: while elevated during resting state linked to lower cognitive abilities children adolescents, increased tasks associated with higher performance. Why does power, measured versus tasks, show differential correlations functioning? This review provides integrated account functional correlates across different contexts. We first present evidence that correlated executive functioning, attentional abilities, language skills, IQ. Next, we research showing increases memory, attention, control, these processes better Finally, discuss potential explanations for between resting/task-related offer suggestions future this area.

Язык: Английский

---

Developmental trajectories of EEG aperiodic and periodic components in children 2–44 months of age

Nature Communications, Год журнала: 2024, Номер 15(1)

Опубликована: Июль 10, 2024

Abstract The development of neural circuits has long-lasting effects on brain function, yet our understanding early circuit in humans remains limited. Here, periodic EEG power features and aperiodic components were examined from longitudinal EEGs collected 592 healthy 2–44 month-old infants, revealing age-dependent nonlinear changes suggestive distinct milestones maturation. Developmental peaks include (1) the presence then absence a 9-10 Hz alpha peak between 2-6 months, (2) high beta (20-30 Hz) 4-18 (3) emergence low (12-20 some infants after six months age. We hypothesized that may reflect maturation thalamocortical network development. Infant anesthesia studies observe GABA-modulating anesthetics do not induce mediated frontal coherence until 10-12 Using small cohort ( n = 23) with before during anesthesia, we provide preliminary evidence have higher anesthesia-induced compared to those without peak.

Язык: Английский

---

The maturation of aperiodic EEG activity across development reveals a progressive differentiation of wakefulness from sleep

NeuroImage, Год журнала: 2023, Номер 277, С. 120264 - 120264

Опубликована: Июль 1, 2023

During development, the brain undergoes radical structural and functional changes following a posterior-to-anterior gradient, associated with profound of cortical electrical activity during both wakefulness sleep. However, systematic assessment developmental effects on aperiodic EEG maturation across vigilance states is lacking, particularly regarding its topographical aspects. Here, in population 160 healthy infants, children teenagers (from 2 to 17 years, 10 subjects for each year), we investigated development Specifically, parameterized shape background Power Spectral Density (PSD) by means spectral exponent offset; reflects rate exponential decay power over increasing frequencies offset an estimate y-intercept PSD. We found that sleep caused EEG-PSD rotate opposite directions: PSD showed flatter reduced while it steeper higher as becomes deeper. deep (N2, N3) only decreased age, indexing broad-band voltage reduction. As result, difference between values those light (N1) increased suggesting progressive differentiation from activity, most prominent frontal regions, latest complete maturation. Notably, stages were entirely separated values, consistently ages line previous findings adults. Concerning location showing steepest largest shifted posterior anterior regions age. This shift, evident sleep, paralleled migration slow wave was consistent neuroanatomical cognitive development. Overall, distinguishes regardless age; while, reveals postero-anterior Our study could help interpret due pathological conditions may elucidate neurophysiological processes underlying

Язык: Английский

---

Human neuronal excitation/inhibition balance explains and predicts neurostimulation induced learning benefits

PLoS Biology, Год журнала: 2023, Номер 21(8), С. e3002193 - e3002193

Опубликована: Авг. 31, 2023

Previous research has highlighted the role of excitation/inhibition (E/I) ratio for typical and atypical development, mental health, cognition, learning. Other benefits high-frequency transcranial random noise stimulation (tRNS)—an excitatory form neurostimulation—on We examined E/I as a potential mechanism studied whether tRNS effect on learning depends measured by aperiodic exponent its putative marker. In addition to manipulating using tRNS, we also manipulated level (learning/overlearning) that been shown influence E/I. Participants ( n = 102) received either sham or 20-minute over dorsolateral prefrontal cortex (DLPFC) during mathematical task. showed increased E/I, reflected exponent, lower predicted greater benefit from specifically contrast previous magnetic resonance spectroscopy (MRS)-based studies, found no A further analysis different data set suggest both measures (EEG versus MRS) may reflect, at least partly, biological mechanisms. Our results highlight marker neurostimulation efficacy This mechanistic understanding provides better opportunities augmented personalized interventions.

Язык: Английский

---

Aperiodic and Hurst EEG exponents across early human brain development: A systematic review

Developmental Cognitive Neuroscience, Год журнала: 2024, Номер 68, С. 101402 - 101402

Опубликована: Июнь 7, 2024

In electroencephalographic (EEG) data, power-frequency slope exponents (1/f_β) can provide non-invasive markers of in vivo neural activity excitation-inhibition (E:I) balance. E:I balance may be altered neurodevelopmental conditions; hence, understanding how 1/f β evolves across infancy/childhood has implications for developing early assessments/interventions. This systematic review (PROSPERO-ID: CRD42023363294) explored the maturation (0-26 yrs) resting-state EEG measures (aperiodic [AE], power law [PLE] and Hurst [HE] exponents), including studies containing ≥1 ≥10 typically participants. Five databases (including Embase Scopus) were searched during March 2023. Forty-two identified (Nparticipants=3478). Risk bias was assessed using Quality Assessment with Diverse Studies tool. Narrative synthesis HE data suggests non-stationary occurs throughout development. Age-related trends complex, rapid decreases AEs infancy heterogenous changes thereafter. Regionally, AE maxima shifted developmentally, potentially reflecting spatial maturing brain connectivity. work highlights importance further characterising development to better understand shapes cognitive

Язык: Английский

---

Aperiodic components and aperiodic-adjusted alpha-band oscillations in children with ADHD

Journal of Psychiatric Research, Год журнала: 2024, Номер 173, С. 225 - 231

Опубликована: Март 26, 2024

Язык: Английский

---

Exploring aperiodic activity in first episode schizophrenia spectrum psychosis: A resting-state EEG analysis

Brain Research, Год журнала: 2024, Номер 1840, С. 149052 - 149052

Опубликована: Июнь 5, 2024

Abnormalities in brain oscillatory patterns have long been observed schizophrenia and psychotic disorders more broadly. However, far less is known about aperiodic neural activity these disorders, which has linked to excitation/inhibition balance neuronal population spiking within the brain. Here, we analysed resting-state electroencephalographic (EEG) recordings from 43 first episode spectrum psychosis (FESSP) patients 28 healthy controls examine whether disrupted FESSP. We further assessed potential associations between FESSP clinical symptom severity using Brief Psychiatric Rating Scale (BPRS), for Assessment of Negative Symptoms (SANS), Positive (SAPS). found no significant differences either 1/f-like exponent or broadband offset control groups when analysing global signal averaged across all EEG electrodes. Bayesian analyses supported non-significant findings. additional non-parametric cluster-based permutation did identify reduced group, relative broad central, temporal, parietal select frontal regions. No were examining participants, irrespective antipsychotic medication status. was shown predict BPRS SANS scores naive patients. In sum, this research presents an initial analysis FESSP, offering preliminary evidence altered disorder. This contributes a broader understanding dynamics early psychosis.

Язык: Английский

---

Examining the impact of prenatal maternal internalizing symptoms and socioeconomic status on children's frontal alpha asymmetry and psychopathology

Developmental Psychobiology, Год журнала: 2024, Номер 66(3)

Опубликована: Март 3, 2024

Abstract Prenatal maternal internalizing psychopathology (depression and anxiety) socioeconomic status (SES) have been independently associated with higher risk for externalizing problems in children. However, the pathways behind these associations are not well understood. Numerous studies linked greater right frontal alpha asymmetry to problems; however, findings mixed. Several also children's asymmetry. Additionally, emerging SES To date, only a limited number of examined within longitudinal design, majority utilized relatively small samples. The current preregistered study utilizes data from large prospective young children ( N = 415; Mean age 7.27 years; Range 5–11 years) examine association between prenatal symptoms, asymmetry, behavior problems. symptoms did predict there was no mothers’ during pregnancy predicted outcomes. Non‐preregistered analyses showed that lower child Additional non‐preregistered find evidence as moderator relation Future research should impact on high‐risk

Язык: Английский

---

ComBat models for harmonization of resting-state EEG features in multisite studies

Clinical Neurophysiology, Год журнала: 2024, Номер 167, С. 241 - 253

Опубликована: Сен. 24, 2024

Язык: Английский

---

A systematic review of aperiodic neural activity in clinical investigations

medRxiv (Cold Spring Harbor Laboratory), Год журнала: 2024, Номер unknown

Опубликована: Окт. 15, 2024

Abstract In the study of neuro-electrophysiological recordings, aperiodic neural activity – with no characteristic frequency has increasingly become a common feature study. This interest rapidly extended to clinical work, many reports investigating from patients broad range disorders. work typically seeks evaluate as putative biomarker relating diagnosis or treatment response, and/or potential marker underlying physiological activity. There is thus far clear consensus on if and how relates disorders, nor best practices for it in research. To address this, this systematic literature review, following PRISMA guidelines, examines electrophysiological recordings human psychiatric neurological finding 143 across 35 distinct Reports within disorders are summarized current findings examine what can be learned pertains analysis, interpretations, overall utility investigations. Aperiodic commonly reported relate diagnoses, 31 reporting significant effect diagnostic related studies. However, there variation consistency results heterogeneity patient groups, disease etiologies, status arising themes different Overall, variability results, potentially confounding covariates, limitations understanding suggests further needed before established pathological physiology. Finally, series recommendations proposed, based findings, limitations, key discussion topics assist guiding productive future studying Project Repository The project repository contains code & data project: https://github.com/TomDonoghue/AperiodicClinical

Язык: Английский

---