Developmental Cognitive Neuroscience,
Год журнала:
2024,
Номер
69, С. 101433 - 101433
Опубликована: Авг. 10, 2024
Neurophysiological
signals,
comprised
of
both
periodic
(e.g.,
oscillatory)
and
aperiodic
non-oscillatory)
activity,
undergo
complex
developmental
changes
between
childhood
adulthood.
With
much
the
existing
literature
primarily
focused
on
features
brain
function,
our
understanding
signals
is
still
in
its
infancy.
Here,
we
are
first
to
examine
age-related
(peak
frequency
power)
(slope
offset)
activity
using
optically
pumped
magnetometers
(OPMs),
a
new,
wearable
magnetoencephalography
(MEG)
technology
that
particularly
well-suited
for
studying
development.
We
examined
these
spectral
sample
(N=65)
toddlers
(1-3
years),
children
(4-5
young
adults
(20-26
(27-38
years).
Consistent
with
extant
literature,
found
significant
decreases
slope
offset,
peak
power
were
frequency-specific;
show
effect
sizes
also
varied
across
regions.
This
work
not
only
adds
growing
body
highlighting
advantages
OPMs,
especially
development,
but
contributes
novel
information
regarding
variation
neurophysiological
age
brain.
Developmental Cognitive Neuroscience,
Год журнала:
2024,
Номер
67, С. 101404 - 101404
Опубликована: Июнь 1, 2024
The
theta
band
is
one
of
the
most
prominent
frequency
bands
in
electroencephalography
(EEG)
power
spectrum
and
presents
an
interesting
paradox:
while
elevated
during
resting
state
linked
to
lower
cognitive
abilities
children
adolescents,
increased
tasks
associated
with
higher
performance.
Why
does
power,
measured
versus
tasks,
show
differential
correlations
functioning?
This
review
provides
integrated
account
functional
correlates
across
different
contexts.
We
first
present
evidence
that
correlated
executive
functioning,
attentional
abilities,
language
skills,
IQ.
Next,
we
research
showing
increases
memory,
attention,
control,
these
processes
better
Finally,
discuss
potential
explanations
for
between
resting/task-related
offer
suggestions
future
this
area.
Nature Communications,
Год журнала:
2024,
Номер
15(1)
Опубликована: Июль 10, 2024
Abstract
The
development
of
neural
circuits
has
long-lasting
effects
on
brain
function,
yet
our
understanding
early
circuit
in
humans
remains
limited.
Here,
periodic
EEG
power
features
and
aperiodic
components
were
examined
from
longitudinal
EEGs
collected
592
healthy
2–44
month-old
infants,
revealing
age-dependent
nonlinear
changes
suggestive
distinct
milestones
maturation.
Developmental
peaks
include
(1)
the
presence
then
absence
a
9-10
Hz
alpha
peak
between
2-6
months,
(2)
high
beta
(20-30
Hz)
4-18
(3)
emergence
low
(12-20
some
infants
after
six
months
age.
We
hypothesized
that
may
reflect
maturation
thalamocortical
network
development.
Infant
anesthesia
studies
observe
GABA-modulating
anesthetics
do
not
induce
mediated
frontal
coherence
until
10-12
Using
small
cohort
(
n
=
23)
with
before
during
anesthesia,
we
provide
preliminary
evidence
have
higher
anesthesia-induced
compared
to
those
without
peak.
NeuroImage,
Год журнала:
2023,
Номер
277, С. 120264 - 120264
Опубликована: Июль 1, 2023
During
development,
the
brain
undergoes
radical
structural
and
functional
changes
following
a
posterior-to-anterior
gradient,
associated
with
profound
of
cortical
electrical
activity
during
both
wakefulness
sleep.
However,
systematic
assessment
developmental
effects
on
aperiodic
EEG
maturation
across
vigilance
states
is
lacking,
particularly
regarding
its
topographical
aspects.
Here,
in
population
160
healthy
infants,
children
teenagers
(from
2
to
17
years,
10
subjects
for
each
year),
we
investigated
development
Specifically,
parameterized
shape
background
Power
Spectral
Density
(PSD)
by
means
spectral
exponent
offset;
reflects
rate
exponential
decay
power
over
increasing
frequencies
offset
an
estimate
y-intercept
PSD.
We
found
that
sleep
caused
EEG-PSD
rotate
opposite
directions:
PSD
showed
flatter
reduced
while
it
steeper
higher
as
becomes
deeper.
deep
(N2,
N3)
only
decreased
age,
indexing
broad-band
voltage
reduction.
As
result,
difference
between
values
those
light
(N1)
increased
suggesting
progressive
differentiation
from
activity,
most
prominent
frontal
regions,
latest
complete
maturation.
Notably,
stages
were
entirely
separated
values,
consistently
ages
line
previous
findings
adults.
Concerning
location
showing
steepest
largest
shifted
posterior
anterior
regions
age.
This
shift,
evident
sleep,
paralleled
migration
slow
wave
was
consistent
neuroanatomical
cognitive
development.
Overall,
distinguishes
regardless
age;
while,
reveals
postero-anterior
Our
study
could
help
interpret
due
pathological
conditions
may
elucidate
neurophysiological
processes
underlying
PLoS Biology,
Год журнала:
2023,
Номер
21(8), С. e3002193 - e3002193
Опубликована: Авг. 31, 2023
Previous
research
has
highlighted
the
role
of
excitation/inhibition
(E/I)
ratio
for
typical
and
atypical
development,
mental
health,
cognition,
learning.
Other
benefits
high-frequency
transcranial
random
noise
stimulation
(tRNS)—an
excitatory
form
neurostimulation—on
We
examined
E/I
as
a
potential
mechanism
studied
whether
tRNS
effect
on
learning
depends
measured
by
aperiodic
exponent
its
putative
marker.
In
addition
to
manipulating
using
tRNS,
we
also
manipulated
level
(learning/overlearning)
that
been
shown
influence
E/I.
Participants
(
n
=
102)
received
either
sham
or
20-minute
over
dorsolateral
prefrontal
cortex
(DLPFC)
during
mathematical
task.
showed
increased
E/I,
reflected
exponent,
lower
predicted
greater
benefit
from
specifically
contrast
previous
magnetic
resonance
spectroscopy
(MRS)-based
studies,
found
no
A
further
analysis
different
data
set
suggest
both
measures
(EEG
versus
MRS)
may
reflect,
at
least
partly,
biological
mechanisms.
Our
results
highlight
marker
neurostimulation
efficacy
This
mechanistic
understanding
provides
better
opportunities
augmented
personalized
interventions.
Developmental Cognitive Neuroscience,
Год журнала:
2024,
Номер
68, С. 101402 - 101402
Опубликована: Июнь 7, 2024
In
electroencephalographic
(EEG)
data,
power-frequency
slope
exponents
(1/f_β)
can
provide
non-invasive
markers
of
in
vivo
neural
activity
excitation-inhibition
(E:I)
balance.
E:I
balance
may
be
altered
neurodevelopmental
conditions;
hence,
understanding
how
1/f
β
evolves
across
infancy/childhood
has
implications
for
developing
early
assessments/interventions.
This
systematic
review
(PROSPERO-ID:
CRD42023363294)
explored
the
maturation
(0-26
yrs)
resting-state
EEG
measures
(aperiodic
[AE],
power
law
[PLE]
and
Hurst
[HE]
exponents),
including
studies
containing
≥1
≥10
typically
participants.
Five
databases
(including
Embase
Scopus)
were
searched
during
March
2023.
Forty-two
identified
(Nparticipants=3478).
Risk
bias
was
assessed
using
Quality
Assessment
with
Diverse
Studies
tool.
Narrative
synthesis
HE
data
suggests
non-stationary
occurs
throughout
development.
Age-related
trends
complex,
rapid
decreases
AEs
infancy
heterogenous
changes
thereafter.
Regionally,
AE
maxima
shifted
developmentally,
potentially
reflecting
spatial
maturing
brain
connectivity.
work
highlights
importance
further
characterising
development
to
better
understand
shapes
cognitive
Brain Research,
Год журнала:
2024,
Номер
1840, С. 149052 - 149052
Опубликована: Июнь 5, 2024
Abnormalities
in
brain
oscillatory
patterns
have
long
been
observed
schizophrenia
and
psychotic
disorders
more
broadly.
However,
far
less
is
known
about
aperiodic
neural
activity
these
disorders,
which
has
linked
to
excitation/inhibition
balance
neuronal
population
spiking
within
the
brain.
Here,
we
analysed
resting-state
electroencephalographic
(EEG)
recordings
from
43
first
episode
spectrum
psychosis
(FESSP)
patients
28
healthy
controls
examine
whether
disrupted
FESSP.
We
further
assessed
potential
associations
between
FESSP
clinical
symptom
severity
using
Brief
Psychiatric
Rating
Scale
(BPRS),
for
Assessment
of
Negative
Symptoms
(SANS),
Positive
(SAPS).
found
no
significant
differences
either
1/f-like
exponent
or
broadband
offset
control
groups
when
analysing
global
signal
averaged
across
all
EEG
electrodes.
Bayesian
analyses
supported
non-significant
findings.
additional
non-parametric
cluster-based
permutation
did
identify
reduced
group,
relative
broad
central,
temporal,
parietal
select
frontal
regions.
No
were
examining
participants,
irrespective
antipsychotic
medication
status.
was
shown
predict
BPRS
SANS
scores
naive
patients.
In
sum,
this
research
presents
an
initial
analysis
FESSP,
offering
preliminary
evidence
altered
disorder.
This
contributes
a
broader
understanding
dynamics
early
psychosis.
Developmental Psychobiology,
Год журнала:
2024,
Номер
66(3)
Опубликована: Март 3, 2024
Abstract
Prenatal
maternal
internalizing
psychopathology
(depression
and
anxiety)
socioeconomic
status
(SES)
have
been
independently
associated
with
higher
risk
for
externalizing
problems
in
children.
However,
the
pathways
behind
these
associations
are
not
well
understood.
Numerous
studies
linked
greater
right
frontal
alpha
asymmetry
to
problems;
however,
findings
mixed.
Several
also
children's
asymmetry.
Additionally,
emerging
SES
To
date,
only
a
limited
number
of
examined
within
longitudinal
design,
majority
utilized
relatively
small
samples.
The
current
preregistered
study
utilizes
data
from
large
prospective
young
children
(
N
=
415;
Mean
age
7.27
years;
Range
5–11
years)
examine
association
between
prenatal
symptoms,
asymmetry,
behavior
problems.
symptoms
did
predict
there
was
no
mothers’
during
pregnancy
predicted
outcomes.
Non‐preregistered
analyses
showed
that
lower
child
Additional
non‐preregistered
find
evidence
as
moderator
relation
Future
research
should
impact
on
high‐risk
medRxiv (Cold Spring Harbor Laboratory),
Год журнала:
2024,
Номер
unknown
Опубликована: Окт. 15, 2024
Abstract
In
the
study
of
neuro-electrophysiological
recordings,
aperiodic
neural
activity
–
with
no
characteristic
frequency
has
increasingly
become
a
common
feature
study.
This
interest
rapidly
extended
to
clinical
work,
many
reports
investigating
from
patients
broad
range
disorders.
work
typically
seeks
evaluate
as
putative
biomarker
relating
diagnosis
or
treatment
response,
and/or
potential
marker
underlying
physiological
activity.
There
is
thus
far
clear
consensus
on
if
and
how
relates
disorders,
nor
best
practices
for
it
in
research.
To
address
this,
this
systematic
literature
review,
following
PRISMA
guidelines,
examines
electrophysiological
recordings
human
psychiatric
neurological
finding
143
across
35
distinct
Reports
within
disorders
are
summarized
current
findings
examine
what
can
be
learned
pertains
analysis,
interpretations,
overall
utility
investigations.
Aperiodic
commonly
reported
relate
diagnoses,
31
reporting
significant
effect
diagnostic
related
studies.
However,
there
variation
consistency
results
heterogeneity
patient
groups,
disease
etiologies,
status
arising
themes
different
Overall,
variability
results,
potentially
confounding
covariates,
limitations
understanding
suggests
further
needed
before
established
pathological
physiology.
Finally,
series
recommendations
proposed,
based
findings,
limitations,
key
discussion
topics
assist
guiding
productive
future
studying
Project
Repository
The
project
repository
contains
code
&
data
project:
https://github.com/TomDonoghue/AperiodicClinical