In vivo whole-cortex marker of excitation-inhibition ratio indexes cortical maturation and cognitive ability in youth

Proceedings of the National Academy of Sciences, Год журнала: 2024, Номер 121(23)

Опубликована: Май 30, 2024

A balanced excitation-inhibition ratio (E/I ratio) is critical for healthy brain function. Normative development of cortex-wide E/I remains unknown. Here, we noninvasively estimate a putative marker whole-cortex by fitting large-scale biophysically plausible circuit model to resting-state functional MRI (fMRI) data. We first confirm that our generates realistic dynamics in the Human Connectome Project. Next, show estimated sensitive gamma-aminobutyric acid (GABA) agonist benzodiazepine alprazolam during fMRI. Alprazolam-induced changes are spatially consistent with positron emission tomography measurement receptor density. then investigate relationship between and neurodevelopment. find declines heterogeneously across cerebral cortex youth, greatest reduction occurring sensorimotor systems relative association systems. Importantly, among children same chronological age, lower (especially cortex) linked better cognitive performance. This result replicated North American (8.2 23.0 y old) Asian (7.2 7.9 cohorts, suggesting more mature indexes improved cognition normative development. Overall, findings open door studying how disrupted trajectories may lead dysfunction psychopathology emerges youth.

Язык: Английский

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Long-range inhibitory neurons mediate cortical neurovascular coupling

Cell Reports, Год журнала: 2024, Номер 43(4), С. 113970 - 113970

Опубликована: Март 19, 2024

To meet the high energy demands of brain function, cerebral blood flow (CBF) parallels changes in neuronal activity by a mechanism known as neurovascular coupling (NVC). However, which neurons play role mediating NVC is not well understood. Here, we identify mice and humans specific population cortical GABAergic that co-express nitric oxide synthase tachykinin receptor 1 (Tacr1). Through whole-tissue clearing, demonstrate Tacr1 extend local long-range projections across functionally connected areas. We show whisker stimulation elicited neuron barrel cortex through feedforward excitatory pathways. Additionally, optogenetic experiments, are instrumental CBF relaxation mural cells similar fashion to stimulation. Finally, electron microscopy, observe processes contact astrocytic endfeet. These findings suggest integrate mediate NVC.

Язык: Английский

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The regional variation of laminar thickness in the human isocortex is related to cortical hierarchy and interregional connectivity

PLoS Biology, Год журнала: 2023, Номер 21(11), С. e3002365 - e3002365

Опубликована: Ноя. 9, 2023

The human isocortex consists of tangentially organized layers with unique cytoarchitectural properties. These show spatial variations in thickness and cytoarchitecture across the neocortex, which is thought to support function through enabling targeted corticocortical connections. Here, leveraging maps 6 cortical based on 3D brain histology, we aimed quantitatively characterize systematic covariation laminar structure cortex its functional consequences. After correcting for effect curvature, identified a pattern changes covariance from lateral frontal posterior occipital regions, differentiated dominance infra- versus supragranular layer thickness. Corresponding regularities connections along hierarchy, infragranular-dominant was associated higher hierarchical positions mapped resting-state effective connectivity humans tract-tracing structural macaques. Moreover, that regions similar patterns have likelihood strength In sum, here organization association cortico-cortical connectivity, illustrating how may provide foundational principle function.

Язык: Английский

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Whole-brain structural connectome asymmetry in autism

NeuroImage, Год журнала: 2024, Номер 288, С. 120534 - 120534

Опубликована: Фев. 8, 2024

Autism spectrum disorder is a common neurodevelopmental condition that manifests as disruption in sensory and social skills. Although it has been shown the brain morphology of individuals with autism asymmetric, how this differentially affects structural connectome organization each hemisphere remains under-investigated. We studied whole-brain connectivity-based asymmetry using diffusion magnetic resonance imaging obtained from Brain Imaging Data Exchange initiative. By leveraging dimensionality reduction techniques, we constructed low-dimensional representations connectivity calculated their index. Comparing index between neurotypical controls, found atypical default-mode regions, particularly showing weaker towards right autism. Network communication provided topological underpinnings by demonstrating inferior temporal cortex limbic frontoparietal regions showed reduced global network efficiency decreased send-receive navigation lateral visual cortices Finally, supervised machine learning revealed could be used measure for predicting communication-related autistic symptoms nonverbal intelligence. Our findings provide insights into macroscale alterations underpinnings.

Язык: Английский

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Low-dimensional controllability of brain networks

PLoS Computational Biology, Год журнала: 2025, Номер 21(1), С. e1012691 - e1012691

Опубликована: Янв. 7, 2025

Identifying the driver nodes of a network has crucial implications in biological systems from unveiling causal interactions to informing effective intervention strategies. Despite recent advances control theory, results remain inaccurate as number drivers becomes too small compared size, thus limiting concrete usability many real-life applications. To overcome this issue, we introduced framework that integrates principles spectral graph theory and output controllability project state into smaller topological space formed by Laplacian structure. Through extensive simulations on synthetic real networks, showed relatively low projected components can significantly improve accuracy. By introducing new low-dimensional metric experimentally validated our method N = 6134 human connectomes obtained UK-biobank cohort. Results revealed previously unappreciated influential brain regions, enabled draw directed maps between differently specialized cerebral systems, yielded insights hemispheric lateralization. Taken together, offered theoretically grounded solution deal with provided brain.

Язык: Английский

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Individual variability in functional connectivity of human auditory cortex

Cerebral Cortex, Год журнала: 2024, Номер 34(2)

Опубликована: Янв. 26, 2024

Abstract Individual variability in functional connectivity underlies individual differences cognition and behaviors, yet its association with specialization the auditory cortex remains elusive. Using resting-state magnetic resonance imaging data from Human Connectome Project, this study was designed to investigate spatial distribution of whole-brain network architecture. An inherent hierarchical axis discerned, which radiates medial lateral orientation, left demonstrating more pronounced variations than right. This exhibited a significant correlation structural metrics cortex. Four subregions, were identified clustering analysis based on variability, unique connectional fingerprints cognitive maps, certain subregions showing specificity speech perception activation. Moreover, lateralization fingerprint U-shaped trajectory across subregions. These findings emphasize role understanding cortical organization, as well revealing activation, connectome, perspectives.

Язык: Английский

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Can hubs of the human connectome be identified consistently with diffusion MRI?

Network Neuroscience, Год журнала: 2023, Номер 7(4), С. 1326 - 1350

Опубликована: Янв. 1, 2023

Recent years have seen a surge in the use of diffusion MRI to map connectomes humans, paralleled by similar increase processing and analysis choices. Yet these different steps their effects are rarely compared systematically. Here, healthy young adult population (n = 294), we characterized impact range pipelines on one widely studied property human connectome: its degree distribution. We evaluated 40 (comparing common choices parcellation, streamline seeding, tractography algorithm, propagation constraint) 44 group-representative connectome reconstruction schemes highly connected hub regions. found that location is variable between pipelines. The choice parcellation has major influence architecture, connectivity correlated with regional surface area most assessed (ρ > 0.70 69% pipelines), particularly when using weighted networks. Overall, our results demonstrate need for prudent decision-making data, carefully considering how can organization.

Язык: Английский

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Altered asymmetry of functional connectome gradients in major depressive disorder

Frontiers in Neuroscience, Год журнала: 2024, Номер 18

Опубликована: Апрель 30, 2024

Introduction Major depressive disorder (MDD) is a debilitating disease involving sensory and higher-order cognitive dysfunction. Previous work has shown altered asymmetry in MDD, including abnormal lateralized activation disrupted hemispheric connectivity. However, it remains unclear whether how MDD affects functional asymmetries the context of intrinsic hierarchical organization. Methods Here, we evaluate intra- inter-hemispheric first three gradients, characterizing unimodal-transmodal, visual-somatosensory, somatomotor/default mode-multiple demand hierarchies, to study MDD-related alterations overarching system-level architecture. Results We find that, relative healthy controls, patients exhibit both primary regions (e.g., visual areas) transmodal association default mode areas). further these abnormalities are woven heterogeneous along multiple associated with terms mind, memory, processing. Moreover, through an elastic net model, observe that inter-asymmetric features predictive traits measured by BDI-II scores. Discussion Altogether, findings highlight broad mixed effect on gradient asymmetry, contributing richer understanding neurobiological underpinnings MDD.

Язык: Английский

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Inter- and intra-hemispheric lateralization alterations in auditory verbal hallucinations of Schizophrenia: insights from resting-state functional connectivity

European Archives of Psychiatry and Clinical Neuroscience, Год журнала: 2025, Номер unknown

Опубликована: Янв. 3, 2025

Язык: Английский

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Local effective connectivity changes after transcranial direct current stimulation in obsessive-compulsive disorder patients

Journal of Affective Disorders, Год журнала: 2025, Номер 374, С. 116 - 127

Опубликована: Янв. 11, 2025

This study investigates the effects of transcranial direct current stimulation (tDCS) on brain network connectivity in individuals with obsessive-compulsive disorder (OCD). In a randomized, double-blind, sham-controlled experimental design anodal tDCS (vs. sham) was applied total 43 right-handed patients OCD, targeting right pre-supplementary motor area (pre-SMA). Cathodal reference electrode put left pre-SMA. The set as 2 mA, duration either 30 s (sham) or 1200 s. Concurrent resting-state functional MRI data were collected following (or stimulation. We employed regression dynamic causal modelling (rDCM) to extract whole effective (EC) matrices subsequently analyzing these through graph theory approaches examine changes activity across different scales. found that compared sham caused significant local connectivity. Increased recruitment level detectable sensorimotor (SMN), indicating enhanced intra-network after active tDCS. Clustering coefficient and efficiency also be increased same area. No regard global Current findings indicate single-session can effectively alter connectivities within SMN OCD patients. Given relevance connected regions for pathophysiology we believe areas might constitute an intervention normalize altered OCD. used single session, which may not reflect long-term effects.

Язык: Английский

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