Advancing neurological disorders therapies: Organic nanoparticles as a key to blood-brain barrier penetration

International Journal of Pharmaceutics, Год журнала: 2025, Номер 670, С. 125186 - 125186

Опубликована: Янв. 8, 2025

The blood-brain barrier (BBB) plays a vital role in protecting the central nervous system (CNS) by preventing entry of harmful pathogens from bloodstream. However, this also presents significant obstacle when it comes to delivering drugs for treatment neurodegenerative diseases and brain cancer. Recent breakthroughs nanotechnology have paved way creation wide range nanoparticles (NPs) that can serve as carriers diagnosis therapy. Regarding their promising properties, organic NPs potential be used effective drug delivery across BBB based on recent advancements. These remarkable ability penetrate using various mechanisms. This review offers comprehensive examination intricate structure distinct properties BBB, emphasizing its crucial function preserving balance regulating transport ions molecules. disruption conditions such stroke, Alzheimer's disease, Parkinson's disease highlights importance developing creative approaches drugs. Through encapsulation therapeutic molecules precise targeting processes vasculature, NP formulations present hopeful strategy improve BBB. We explore changes pathological investigate factors affect successful into brain. In addition, we most systems associated with shown positive results treating ischemic disorders. opens up new possibilities nanotechnology-based therapies cerebral diseases.

Язык: Английский

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The Role of Sirtuin 1 in Ageing and Neurodegenerative Disease: A Molecular Perspective

Ageing Research Reviews, Год журнала: 2024, Номер 102, С. 102545 - 102545

Опубликована: Окт. 17, 2024

Язык: Английский

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Therapeutic modulation of mitochondrial dynamics by agmatine in neurodegenerative disorders

Neuroscience, Год журнала: 2025, Номер unknown

Опубликована: Янв. 1, 2025

Язык: Английский

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Synaptic plasticity and neuroprotection: The molecular impact of flavonoids on neurodegenerative disease progression

Neuroscience, Год журнала: 2025, Номер 569, С. 161 - 183

Опубликована: Фев. 7, 2025

Язык: Английский

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Design and Implementation Evaluation of Personalized and Differentiated Teaching Strategies for Preschool Children Based on Fuzzy Decision Support Systems

International Journal of Computational Intelligence Systems, Год журнала: 2025, Номер 18(1)

Опубликована: Фев. 27, 2025

Язык: Английский

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Identification of depressing tweets using natural language processing and machine learning: Application of grey relational grades

Journal of Radiation Research and Applied Sciences, Год журнала: 2025, Номер 18(1), С. 101299 - 101299

Опубликована: Янв. 20, 2025

Язык: Английский

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Abnormal resting-state brain network dynamics in toddlers with autism spectrum disorder

European Child & Adolescent Psychiatry, Год журнала: 2025, Номер unknown

Опубликована: Янв. 24, 2025

Язык: Английский

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Targeted drug delivery in neurodegenerative diseases: the role of nanotechnology

Frontiers in Medicine, Год журнала: 2025, Номер 12

Опубликована: Янв. 29, 2025

Neurodegenerative diseases, characterized by progressive neuronal loss and cognitive impairments, pose a significant global health challenge. This study explores the potential of nanotherapeutics as promising approach to enhance drug delivery across physiological barriers, particularly blood–brain barrier (BBB) blood-cerebrospinal fluid (B-CSFB). By employing nanoparticles, this research aims address critical challenges in diagnosis treatment conditions such Alzheimer’s, Parkinson’s, Huntington’s diseases. The multifactorial nature these disorders necessitates innovative solutions that leverage nanomedicine improve solubility, circulation time, targeted while minimizing off-target effects. findings underscore importance advancing applications develop effective therapeutic strategies can alleviate burden neurodegenerative diseases on individuals healthcare systems.

Язык: Английский

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EEG electrode setup optimization using feature extraction techniques for neonatal sleep state classification

Frontiers in Computational Neuroscience, Год журнала: 2025, Номер 19

Опубликована: Янв. 31, 2025

An optimal arrangement of electrodes during data collection is essential for gaining a deeper understanding neonatal sleep and assessing cognitive health in order to reduce technical complexity skin irritation risks. Using electroencephalography (EEG) data, long-short-term memory (LSTM) classifier categorizes states. 16,803 30-second segment was collected from 64 infants between 36 43 weeks age at Fudan University Children's Hospital train test the proposed model. To enhance performance an LSTM-based classification model, 94 linear nonlinear features time frequency domains with three novel (Detrended Fluctuation Analysis (DFA), Lyapunov exponent, multiscale fluctuation entropy) are extracted. imbalance classes solved using SMOTE technique. In addition, most significant identified prioritized principal component analysis (PCA). comparison other single channels, C3 channel has accuracy value 80.75% ± 0.82%, kappa 0.76. Classification four left-side higher (82.71% 0.88%) than right-side (81.14% 0.77%), while values respectively 0.78 Study results suggest that specific EEG channels play important role determining stage classification, as well suggesting electrode configuration. Moreover, this research can be used improve care by monitoring sleep, which allow early detection disorders. As result, study captures information effectively channel, reducing computing load maintaining same time. With incorporation frequency-domain into staging, newborn dynamics irregularities better understood.

Язык: Английский

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Lights and shadows of clozapine on the immune system in schizophrenia: a narrative literature review

Metabolic Brain Disease, Год журнала: 2025, Номер 40(2)

Опубликована: Фев. 15, 2025

Язык: Английский

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