The effect of clozapine on immune-related biomarkers in schizophrenia patients DOI Creative Commons

Lu Shao,

Li Yu,

ZhiYao Yuan

et al.

Brain Research Bulletin, Journal Year: 2024, Volume and Issue: unknown, P. 111104 - 111104

Published: Oct. 1, 2024

Language: Английский

Advancing neurological disorders therapies: Organic nanoparticles as a key to blood-brain barrier penetration DOI Creative Commons
Zahra Razavi,

Seyed Sina Alizadeh,

F. S. Razavi

et al.

International Journal of Pharmaceutics, Journal Year: 2025, Volume and Issue: 670, P. 125186 - 125186

Published: Jan. 8, 2025

The blood-brain barrier (BBB) plays a vital role in protecting the central nervous system (CNS) by preventing entry of harmful pathogens from bloodstream. However, this also presents significant obstacle when it comes to delivering drugs for treatment neurodegenerative diseases and brain cancer. Recent breakthroughs nanotechnology have paved way creation wide range nanoparticles (NPs) that can serve as carriers diagnosis therapy. Regarding their promising properties, organic NPs potential be used effective drug delivery across BBB based on recent advancements. These remarkable ability penetrate using various mechanisms. This review offers comprehensive examination intricate structure distinct properties BBB, emphasizing its crucial function preserving balance regulating transport ions molecules. disruption conditions such stroke, Alzheimer's disease, Parkinson's disease highlights importance developing creative approaches drugs. Through encapsulation therapeutic molecules precise targeting processes vasculature, NP formulations present hopeful strategy improve BBB. We explore changes pathological investigate factors affect successful into brain. In addition, we most systems associated with shown positive results treating ischemic disorders. opens up new possibilities nanotechnology-based therapies cerebral diseases.

Language: Английский

Citations

8
The Role of Sirtuin 1 in Ageing and Neurodegenerative Disease: A Molecular Perspective DOI
Riya Thapa, Ehssan Moglad, Muhammad Afzal

et al.

Ageing Research Reviews, Journal Year: 2024, Volume and Issue: 102, P. 102545 - 102545

Published: Oct. 17, 2024

Language: Английский

Citations

10
Therapeutic modulation of mitochondrial dynamics by agmatine in neurodegenerative disorders DOI

Dhanshree Nibrad,

Amit Shiwal,

Manasi Tadas

et al.

Neuroscience, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 1, 2025

Language: Английский

Citations

1
Synaptic plasticity and neuroprotection: The molecular impact of flavonoids on neurodegenerative disease progression DOI

Spandana Rajendra Kopalli,

Tapan Behl,

Ashishkumar Kyada

et al.

Neuroscience, Journal Year: 2025, Volume and Issue: 569, P. 161 - 183

Published: Feb. 7, 2025

Language: Английский

Citations

1
Design and Implementation Evaluation of Personalized and Differentiated Teaching Strategies for Preschool Children Based on Fuzzy Decision Support Systems DOI Creative Commons

Yali Hou

International Journal of Computational Intelligence Systems, Journal Year: 2025, Volume and Issue: 18(1)

Published: Feb. 27, 2025

Language: Английский

Citations

1
Identification of depressing tweets using natural language processing and machine learning: Application of grey relational grades DOI
Wusat Ullah, Patrícia Oliveira‐Silva, Muhammad Nawaz

et al.

Journal of Radiation Research and Applied Sciences, Journal Year: 2025, Volume and Issue: 18(1), P. 101299 - 101299

Published: Jan. 20, 2025

Language: Английский

Citations

0
Abnormal resting-state brain network dynamics in toddlers with autism spectrum disorder DOI

Xiuxian Li,

Shengjuan Wu,

Wenzhong Yang

et al.

European Child & Adolescent Psychiatry, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 24, 2025

Language: Английский

Citations

0
Targeted drug delivery in neurodegenerative diseases: the role of nanotechnology DOI Creative Commons

Rupal Dhariwal,

Mukul Jain, Y. Mir

et al.

Frontiers in Medicine, Journal Year: 2025, Volume and Issue: 12

Published: Jan. 29, 2025

Neurodegenerative diseases, characterized by progressive neuronal loss and cognitive impairments, pose a significant global health challenge. This study explores the potential of nanotherapeutics as promising approach to enhance drug delivery across physiological barriers, particularly blood–brain barrier (BBB) blood-cerebrospinal fluid (B-CSFB). By employing nanoparticles, this research aims address critical challenges in diagnosis treatment conditions such Alzheimer’s, Parkinson’s, Huntington’s diseases. The multifactorial nature these disorders necessitates innovative solutions that leverage nanomedicine improve solubility, circulation time, targeted while minimizing off-target effects. findings underscore importance advancing applications develop effective therapeutic strategies can alleviate burden neurodegenerative diseases on individuals healthcare systems.

Language: Английский

Citations

0
EEG electrode setup optimization using feature extraction techniques for neonatal sleep state classification DOI Creative Commons
Hafza Ayesha Siddiqa, Muhammad Farrukh Qureshi, A.A. Khurshid

et al.

Frontiers in Computational Neuroscience, Journal Year: 2025, Volume and Issue: 19

Published: Jan. 31, 2025

An optimal arrangement of electrodes during data collection is essential for gaining a deeper understanding neonatal sleep and assessing cognitive health in order to reduce technical complexity skin irritation risks. Using electroencephalography (EEG) data, long-short-term memory (LSTM) classifier categorizes states. 16,803 30-second segment was collected from 64 infants between 36 43 weeks age at Fudan University Children's Hospital train test the proposed model. To enhance performance an LSTM-based classification model, 94 linear nonlinear features time frequency domains with three novel (Detrended Fluctuation Analysis (DFA), Lyapunov exponent, multiscale fluctuation entropy) are extracted. imbalance classes solved using SMOTE technique. In addition, most significant identified prioritized principal component analysis (PCA). comparison other single channels, C3 channel has accuracy value 80.75% ± 0.82%, kappa 0.76. Classification four left-side higher (82.71% 0.88%) than right-side (81.14% 0.77%), while values respectively 0.78 Study results suggest that specific EEG channels play important role determining stage classification, as well suggesting electrode configuration. Moreover, this research can be used improve care by monitoring sleep, which allow early detection disorders. As result, study captures information effectively channel, reducing computing load maintaining same time. With incorporation frequency-domain into staging, newborn dynamics irregularities better understood.

Language: Английский

Citations

0
Lights and shadows of clozapine on the immune system in schizophrenia: a narrative literature review DOI
Jian Li, Weimin Zhao, Yitong Wang

et al.

Metabolic Brain Disease, Journal Year: 2025, Volume and Issue: 40(2)

Published: Feb. 15, 2025

Language: Английский

Citations

0