The Inflammatory Mechanism of Parkinson’s Disease: Gut Microbiota Metabolites Affect the Development of the Disease Through the Gut–Brain Axis
Brain Sciences,
Год журнала:
2025,
Номер
15(2), С. 159 - 159
Опубликована: Фев. 6, 2025
Parkinson's
disease
is
recognized
as
the
second
most
prevalent
neurodegenerative
disorder
globally,
with
its
incidence
rate
projected
to
increase
alongside
ongoing
population
growth.
However,
precise
etiology
of
remains
elusive.
This
article
explores
inflammatory
mechanisms
linking
gut
microbiota
disease,
emphasizing
alterations
in
and
their
metabolites
that
influence
disease's
progression
through
bidirectional
transmission
signals
along
gut-brain
axis.
Building
on
this
mechanistic
framework,
further
discusses
research
methodologies
treatment
strategies
focused
metabolites,
including
metabolomics
detection
techniques,
animal
model
investigations,
therapeutic
approaches
such
dietary
interventions,
probiotic
treatments,
fecal
transplantation.
Ultimately,
aims
elucidate
relationship
between
underlying
thereby
paving
way
for
novel
avenues
condition.
Язык: Английский
Transcutaneous vagus nerve stimulation: a bibliometric study on current research hotspots and status
Frontiers in Neuroscience,
Год журнала:
2024,
Номер
18
Опубликована: Авг. 16, 2024
Background
Transcutaneous
Vagal
Nerve
Stimulation
(tVNS)
has
been
used
as
a
promising
noninvasive
neuromodulation
technique
for
the
treatment
of
various
systems.The
aim
this
study
was
to
analyze
research
hotspots
and
future
directions
tVNS
in
21st
century
by
using
bibliometric
methods.
Methods
The
object
literature
related
from
Web
Science
database
2000
May
2024.
In
order
measure
number
issuance,
institutions,
authors,
countries,
keywords,
co-citations,
journals
publication,
we
VOSviewer,
Citespace,
Bibliometrix
R-package,
Scimago
Graphica
software.
A
narrative
review
current
content
conducted
gain
better
understanding
state
field.
Results
total
569
papers
were
included
study.
results
show
that
2024,
publications
shows
an
increasing
trend
year
year,
involving
326
institutions.
United
States,
China,
Germany
are
major
centers.
identified
399
which
roughly
formed
11
natural
clusters,
revealing
mainly
reflected
3
areas:
intervention
efficacy
on
nervous
system
diseases,
mechanism
action
tVNS,
stimulation
mode
tVNS.
top
10
most
cited
references
focus
into
Conclusion
safety
have
confirmed
previous
studies,
but
standardized
protocol
not
yet
developed,
clinical
studies
small
sample
sizes
lack
multicenter
multidisciplinary
collaboration.
Currently,
is
neurological
psychiatric
cardiovascular
some
autoimmune
diseases.
It
expected
field
will
continue
application
central
diseases
exploration
mechanisms,
at
same
time,
with
rise
non-invasive
technology,
other
also
great
potential
development.
Язык: Английский
Role of Antioxidants in Modulating the Microbiota–Gut–Brain Axis and Their Impact on Neurodegenerative Diseases
International Journal of Molecular Sciences,
Год журнала:
2025,
Номер
26(8), С. 3658 - 3658
Опубликована: Апрель 12, 2025
This
narrative
review
presents
the
role
of
antioxidants
in
regulating
gut
microbiota
and
impact
on
gut–brain
axis,
with
a
particular
focus
neurodegenerative
diseases,
such
as
Alzheimer’s
(AD)
Parkinson’s
disease
(PD).
These
diseases
are
characterised
by
cognitive
decline,
motor
dysfunction,
neuroinflammation,
all
which
significantly
exacerbated
oxidative
stress.
elucidates
contribution
damage
to
progression
explores
potential
mitigate
these
pathological
processes
through
modulation
associated
pathways.
Based
recent
studies
retrieved
from
reputable
databases,
including
PubMed,
Web
Science,
Scopus,
this
article
outlines
mechanisms
influence
health
exert
neuroprotective
effects.
Specifically,
it
discusses
how
antioxidants,
polyphenols,
vitamins,
flavonoids,
contribute
reduction
reactive
oxygen
species
(ROS)
production
thereby
promoting
neuronal
survival
minimising
brain.
In
addition,
modulating
key
molecular
pathways
involved
stress
NF-κB,
Nrf2,
MAPK,
PI3K/AKT
pathways,
regulate
ROS
generation,
inflammatory
cytokine
expression,
antioxidant
responses
essential
for
maintaining
cellular
homeostasis
both
central
nervous
system.
complex
relationship
between
gut-derived
metabolites,
stress,
highlighting
dysbiosis—an
imbalance
microbiota—can
exacerbate
accelerating
AD
PD.
The
also
examines
short-chain
fatty
acids
(SCFAs)
produced
beneficial
bacteria
attenuate
neuroinflammation
damage.
Furthermore,
therapeutic
microbiota-targeted
interventions,
delivery
probiotics
prebiotics,
innovative
strategies
restore
microbial
support
brain
health.
By
synthesising
current
knowledge
interplay
underlying
neurodegeneration,
highlights
promise
antioxidant-based
interventions
mitigating
progression.
It
need
further
research
into
antioxidant-rich
dietary
microbiota-focused
therapies
promising
avenues
prevention
treatment
diseases.
Язык: Английский
How leaky is the gut in Parkinson’s disease?
EBioMedicine,
Год журнала:
2025,
Номер
117, С. 105796 - 105796
Опубликована: Июнь 3, 2025
Язык: Английский
The Vagus Nerve and the Brain-Gut Axis: Implications for Neuropsychiatric Disorders
Journal of Neuropsychiatry,
Год журнала:
2024,
Номер
36(4), С. 278 - 282
Опубликована: Окт. 1, 2024
Язык: Английский
Enteric neuropathy and the vagus nerve: Therapeutic implications
Neurogastroenterology & Motility,
Год журнала:
2024,
Номер
unknown
Опубликована: Июнь 14, 2024
Abstract
Enteric
neuropathies
are
characterized
by
abnormalities
of
gut
innervation,
which
includes
the
enteric
nervous
system,
inducing
severe
dysmotility
among
other
dysfunctions.
Most
gastrointestinal
tract
is
innervated
vagus
nerve,
efferent
branches
have
close
interconnections
with
system
and
whose
afferents
distributed
throughout
different
layers
digestive
wall.
The
nerve
a
key
element
autonomic
involved
in
stress
response,
at
interface
microbiota‐gut‐brain
axis,
has
anti‐inflammatory
prokinetic
properties,
modulates
intestinal
permeability,
significant
capacity
plasticity
regeneration.
Targeting
these
properties
stimulation
(or
non‐stimulation/
pharmacological
methods),
could
be
interest
therapeutic
management
neuropathies.
Язык: Английский
Probiotic Supplementation in the Neonatal Age Group and the Risk of Hospitalisation in the First Two Years: A Data Linkage Study from Western Australia
Nutrients,
Год журнала:
2024,
Номер
16(13), С. 2094 - 2094
Опубликована: Июнь 30, 2024
Background:
Probiotic
supplementation
in
preterm
neonates
is
standard
practice
many
centres
across
the
globe.
The
impact
of
probiotic
neonatal
age
group
on
risk
hospitalisation
infancy
has
not
been
reported
previously.
Methods:
Infants
born
<
32
+
6
weeks
gestation
Western
Australia
were
eligible
for
inclusion.
We
conducted
a
retrospective
cohort
study
comparing
data
from
before
(Epoch
1:
1
December
2008–30
November
2010,
n
=
1238)
versus
after
2:
June
2012–30
May
2014,
1422)
risks
respiratory-
and
gastrointestinal
infection–related
hospitalisation.
A
subgroup
analysis
infants
28
was
analysed
separately
similar
outcomes.
Results:
Compared
to
Epoch
1,
an
8%
reduction
incidence
up
2
years
birth
observed
(adjusted
rate
ratio
(IRR)
0.92;
95%
confidence
interval
(CI);
0.87–0.98),
adjusted
gestational
age,
smoking,
socioeconomic
status,
maternal
age.
comparable
epochs
2.
Conclusion:
exposed
period
experience
reduced
first
two
discharge
unit.
Язык: Английский