Cold Spring Harbor Perspectives in Biology,
Год журнала:
2012,
Номер
4(6), С. a005710 - a005710
Опубликована: Апрель 17, 2012
Long-term
potentiation
and
long-term
depression
(LTP/LTD)
can
be
elicited
by
activating
N-methyl-d-aspartate
(NMDA)-type
glutamate
receptors,
typically
the
coincident
activity
of
pre-
postsynaptic
neurons.
The
early
phases
expression
are
mediated
a
redistribution
AMPA-type
receptors:
More
receptors
added
to
potentiate
synapse
or
removed
weaken
synapses.
With
time,
structural
changes
become
apparent,
which
in
general
require
synthesis
new
proteins.
investigation
molecular
cellular
mechanisms
underlying
these
forms
synaptic
plasticity
has
received
much
attention,
because
NMDA
receptor-dependent
LTP
LTD
may
constitute
substrates
learning
memory.
Pharmacological Reviews,
Год журнала:
2010,
Номер
62(3), С. 405 - 496
Опубликована: Авг. 17, 2010
The
mammalian
ionotropic
glutamate
receptor
family
encodes
18
gene
products
that
coassemble
to
form
ligand-gated
ion
channels
containing
an
agonist
recognition
site,
a
transmembrane
permeation
pathway,
and
gating
elements
couple
agonist-induced
conformational
changes
the
opening
or
closing
of
pore.
Glutamate
receptors
mediate
fast
excitatory
synaptic
transmission
in
central
nervous
system
are
localized
on
neuronal
non-neuronal
cells.
These
regulate
broad
spectrum
processes
brain,
spinal
cord,
retina,
peripheral
system.
postulated
play
important
roles
numerous
neurological
diseases
have
attracted
intense
scrutiny.
description
structure,
including
its
elements,
reveals
complex
assembly
multiple
semiautonomous
extracellular
domains
linked
pore-forming
element
with
striking
resemblance
inverted
potassium
channel.
In
this
review
we
discuss
International
Union
Basic
Clinical
Pharmacology
nomenclature,
assembly,
accessory
subunits,
interacting
proteins,
expression
translation,
post-translational
modifications,
antagonist
pharmacology,
allosteric
modulation,
mechanisms
permeation,
normal
physiological
function,
as
well
potential
therapeutic
use
pharmacological
agents
acting
at
receptors.
Annual Review of Neuroscience,
Год журнала:
2006,
Номер
29(1), С. 565 - 598
Опубликована: Апрель 7, 2006
Addiction
is
a
state
of
compulsive
drug
use;
despite
treatment
and
other
attempts
to
control
taking,
addiction
tends
persist.
Clinical
laboratory
observations
have
converged
on
the
hypothesis
that
represents
pathological
usurpation
neural
processes
normally
serve
reward-related
learning.
The
major
substrates
persistent
use
are
hypothesized
be
molecular
cellular
mechanisms
underlie
long-term
associative
memories
in
several
forebrain
circuits
(involving
ventral
dorsal
striatum
prefrontal
cortex)
receive
input
from
midbrain
dopamine
neurons.
Here
we
review
progress
identifying
candidate
addiction.
Annual Review of Neuroscience,
Год журнала:
2008,
Номер
31(1), С. 25 - 46
Опубликована: Фев. 14, 2008
Spike
timing-dependent
plasticity
(STDP)
as
a
Hebbian
synaptic
learning
rule
has
been
demonstrated
in
various
neural
circuits
over
wide
spectrum
of
species,
from
insects
to
humans.
The
dependence
modification
on
the
order
pre-
and
postsynaptic
spiking
within
critical
window
tens
milliseconds
profound
functional
implications.
Over
past
decade,
significant
progress
made
understanding
cellular
mechanisms
STDP
at
both
excitatory
inhibitory
synapses
associated
changes
neuronal
excitability
integration.
Beyond
basic
asymmetric
window,
recent
studies
have
also
revealed
several
layers
complexity
STDP,
including
its
dendritic
location,
nonlinear
integration
induced
by
complex
spike
trains,
modulation
neuromodulatory
inputs.
Finally,
consequences
examined
directly
an
increasing
number
vivo.
