Pflügers Archiv - European Journal of Physiology, Год журнала: 2009, Номер 459(3), С. 441 - 449
Опубликована: Сен. 30, 2009
Язык: Английский
Pflügers Archiv - European Journal of Physiology, Год журнала: 2009, Номер 459(3), С. 441 - 449
Опубликована: Сен. 30, 2009
Язык: Английский
Physiological Reviews, Год журнала: 2019, Номер 99(4), С. 1877 - 2013
Опубликована: Авг. 28, 2019
The importance of the gut-brain axis in maintaining homeostasis has long been appreciated. However, past 15 yr have seen emergence microbiota (the trillions microorganisms within and on our bodies) as one key regulators function led to appreciation a distinct microbiota-gut-brain axis. This is gaining ever more traction fields investigating biological physiological basis psychiatric, neurodevelopmental, age-related, neurodegenerative disorders. brain communicate with each other via various routes including immune system, tryptophan metabolism, vagus nerve enteric nervous involving microbial metabolites such short-chain fatty acids, branched chain amino peptidoglycans. Many factors can influence composition early life, infection, mode birth delivery, use antibiotic medications, nature nutritional provision, environmental stressors, host genetics. At extreme diversity diminishes aging. Stress, particular, significantly impact at all stages life. Much recent work implicated gut many conditions autism, anxiety, obesity, schizophrenia, Parkinson’s disease, Alzheimer’s disease. Animal models paramount linking regulation fundamental neural processes, neurogenesis myelination, microbiome activation microglia. Moreover, translational human studies are ongoing will greatly enhance field. Future focus understanding mechanisms underlying attempt elucidate microbial-based intervention therapeutic strategies for neuropsychiatric
Язык: Английский
Процитировано
3512Pharmacological Reviews, Год журнала: 2010, Номер 62(3), С. 405 - 496
Опубликована: Авг. 17, 2010
The mammalian ionotropic glutamate receptor family encodes 18 gene products that coassemble to form ligand-gated ion channels containing an agonist recognition site, a transmembrane permeation pathway, and gating elements couple agonist-induced conformational changes the opening or closing of pore. Glutamate receptors mediate fast excitatory synaptic transmission in central nervous system are localized on neuronal non-neuronal cells. These regulate broad spectrum processes brain, spinal cord, retina, peripheral system. postulated play important roles numerous neurological diseases have attracted intense scrutiny. description structure, including its elements, reveals complex assembly multiple semiautonomous extracellular domains linked pore-forming element with striking resemblance inverted potassium channel. In this review we discuss International Union Basic Clinical Pharmacology nomenclature, assembly, accessory subunits, interacting proteins, expression translation, post-translational modifications, antagonist pharmacology, allosteric modulation, mechanisms permeation, normal physiological function, as well potential therapeutic use pharmacological agents acting at receptors.
Язык: Английский
Процитировано
3288Neuropsychopharmacology, Год журнала: 2009, Номер 35(1), С. 147 - 168
Опубликована: Сен. 30, 2009
Язык: Английский
Процитировано
1223Nature reviews. Neuroscience, Год журнала: 2009, Номер 10(12), С. 850 - 860
Опубликована: Ноя. 20, 2009
Язык: Английский
Процитировано
981Neuropharmacology, Год журнала: 2011, Номер 62(1), С. 63 - 77
Опубликована: Авг. 6, 2011
Язык: Английский
Процитировано
954Molecular Psychiatry, Год журнала: 2018, Номер 23(4), С. 801 - 811
Опубликована: Март 13, 2018
Язык: Английский
Процитировано
915Sleep Medicine Reviews, Год журнала: 2018, Номер 43, С. 96 - 105
Опубликована: Ноя. 15, 2018
Язык: Английский
Процитировано
890Neuron, Год журнала: 2009, Номер 62(6), С. 788 - 801
Опубликована: Июнь 1, 2009
Язык: Английский
Процитировано
889Nature Medicine, Год журнала: 2016, Номер 22(4), С. 345 - 361
Опубликована: Апрель 1, 2016
Язык: Английский
Процитировано
780Advanced Materials, Год журнала: 2019, Номер 31(49)
Опубликована: Сен. 24, 2019
As the research on artificial intelligence booms, there is broad interest in brain-inspired computing using novel neuromorphic devices. The potential of various emerging materials and devices for has attracted extensive efforts, leading to a large number publications. Going forward, order better emulate brain's functions, its relevant fundamentals, working mechanisms, resultant behaviors need be re-visited, understood, connected electronics. A systematic overview biological neural systems given, along with their related critical mechanisms. Recent progress reviewed and, more importantly, existing challenges are highlighted hopefully shed light future directions.
Язык: Английский
Процитировано
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