Epigenetic Regulations of GABAergic Neurotransmission: Relevance for Neurological Disorders and Epigenetic Therapy

Medical Epigenetics, Год журнала: 2016, Номер 4(1), С. 1 - 19

Опубликована: Март 23, 2016

Reelin, a large glycoprotein secreted by telencephalic GABAergic neurons, plays an important role in neuronal guidance embryonically and synaptic plasticity postnatally. The reeler heterozygous mouse (+/rl) appears superficially normal but has been of interest as animal model for psychosis since the discovery that reelin is 50% down-regulated postmortem psychotic brain. Brain abnormalities +/rl are similar to brain include reduction glutamic acid de carboxylase 67 (GAD67), dendritic arbors spine density cortex hippocampus, function including long-term potentiation (LTP). In spite these abnormalities, behavioral subtle controversial. Recent findings indicate (RELN) GAD67 promoters hypermethylated neurons DNA methyltransferase 1 (DNMT1) up-regulated. Hypermethlyation RELN can be induced treating mice with methionine, display +/rl. Thus, combines genetic heterozygocity epigenesis holds promise understanding Reelin down-regulation psychosis.

Язык: Английский

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DNA Methylation and Its Basic Function

Neuropsychopharmacology, Год журнала: 2012, Номер 38(1), С. 23 - 38

Опубликована: Июль 11, 2012

Язык: Английский

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Neurotrophin regulation of neural circuit development and function

Nature reviews. Neuroscience, Год журнала: 2012, Номер 14(1), С. 7 - 23

Опубликована: Дек. 20, 2012

Язык: Английский

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MeCP2, a Key Contributor to Neurological Disease, Activates and Represses Transcription

Science, Год журнала: 2008, Номер 320(5880), С. 1224 - 1229

Опубликована: Май 29, 2008

Mutations in the gene encoding transcriptional repressor methyl-CpG binding protein 2 (MeCP2) cause neurodevelopmental disorder Rett syndrome. Loss of function as well increased dosage MECP2 a host neuropsychiatric disorders. To explore molecular mechanism(s) underlying these disorders, we examined expression patterns hypothalamus mice that either lack or overexpress MeCP2. In both models, MeCP2 dysfunction induced changes levels thousands genes, but unexpectedly majority genes (approximately 85%) appeared to be activated by We selected six and confirmed binds their promoters. Furthermore, showed associates with activator CREB1 at promoter an target not repressed target. These studies suggest regulates wide range it can transcription.

Язык: Английский

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Dendritic spine pathology in neuropsychiatric disorders

Nature Neuroscience, Год журнала: 2011, Номер 14(3), С. 285 - 293

Опубликована: Фев. 23, 2011

Язык: Английский

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Epigenetic regulation in psychiatric disorders

Nature reviews. Neuroscience, Год журнала: 2007, Номер 8(5), С. 355 - 367

Опубликована: Апрель 24, 2007

Язык: Английский

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A Model for Neural Development and Treatment of Rett Syndrome Using Human Induced Pluripotent Stem Cells

Cell, Год журнала: 2010, Номер 143(4), С. 527 - 539

Опубликована: Ноя. 1, 2010

Язык: Английский

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The Story of Rett Syndrome: From Clinic to Neurobiology

Neuron, Год журнала: 2007, Номер 56(3), С. 422 - 437

Опубликована: Ноя. 1, 2007

Язык: Английский

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Dynamic DNA methylation programs persistent adverse effects of early-life stress

Nature Neuroscience, Год журнала: 2009, Номер 12(12), С. 1559 - 1566

Опубликована: Ноя. 8, 2009

Язык: Английский

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Excitatory/Inhibitory Balance and Circuit Homeostasis in Autism Spectrum Disorders

Neuron, Год журнала: 2015, Номер 87(4), С. 684 - 698

Опубликована: Авг. 1, 2015

Язык: Английский

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