Brain,
Год журнала:
2016,
Номер
139(3), С. 662 - 673
Опубликована: Фев. 11, 2016
Physical
exercise
can
convey
a
protective
effect
against
cognitive
decline
in
ageing
and
Alzheimer's
disease.
While
the
long-term
health-promoting
effects
of
are
encouraging,
it's
potential
to
induce
neuronal
vascular
plasticity
brain
is
still
poorly
understood.
It
remains
unclear
whether
slows
trajectory
normal
by
modifying
metabolic
risk
factors
and/or
consistently
boosts
function
inducing
structural
neurochemical
changes
hippocampus
related
medial
temporal
lobe
circuitry—brain
areas
that
important
for
learning
memory.
Hence,
it
be
established
what
extent
interventions
old
age
improve
above
beyond
preservation
function.
Existing
data
suggest
trials
aiming
improvement
may
require
different
outcome
measures
balance
between
two
depend
on
intensity
duration,
presence
preclinical
disease
pathology,
genetic
variability.
activity
offer
protection
neurodegenerative
diseases,
but
or
unclear.
Duzel
et
al.
examine
evidence
improves
hippocampal
discuss
avenues
future
research.
Cellular and Molecular Neurobiology,
Год журнала:
2017,
Номер
38(3), С. 579 - 593
Опубликована: Июнь 16, 2017
Brain-derived
neurotrophic
factor
(BDNF)
is
one
of
the
most
widely
distributed
and
extensively
studied
neurotrophins
in
mammalian
brain.
Among
its
prominent
functions,
can
mention
control
neuronal
glial
development,
neuroprotection,
modulation
both
short-
long-lasting
synaptic
interactions,
which
are
critical
for
cognition
memory.
A
wide
spectrum
processes
controlled
by
BDNF,
sometimes
contradictory
effects
action
be
explained
based
on
specific
pattern
synthesis,
comprising
several
intermediate
biologically
active
isoforms
that
bind
to
different
types
receptor,
triggering
signaling
pathways.
The
functions
BDNF
must
discussed
close
relation
stage
brain
cellular
components
nervous
tissue,
as
well
molecular
mechanisms
signal
transduction
activated
under
physiological
pathological
conditions.
In
this
review,
we
briefly
summarize
current
state
knowledge
regarding
impact
regulation
neurophysiological
processes.
importance
future
studies
aimed
at
disclosing
activation
pathways,
neuro-
gliogenesis,
plasticity
highlighted.
Chemical Reviews,
Год журнала:
2016,
Номер
116(17), С. 9683 - 9747
Опубликована: Апрель 27, 2016
The
use
of
photochemical
transformations
is
a
powerful
strategy
that
allows
for
the
formation
high
degree
molecular
complexity
from
relatively
simple
building
blocks
in
single
step.
A
central
feature
all
light-promoted
involvement
electronically
excited
states,
generated
upon
absorption
photons.
This
produces
transient
reactive
intermediates
and
significantly
alters
reactivity
chemical
compound.
input
energy
provided
by
light
thus
offers
means
to
produce
strained
unique
target
compounds
cannot
be
assembled
using
thermal
protocols.
review
aims
at
highlighting
as
tool
rapidly
accessing
structurally
stereochemically
diverse
scaffolds.
Synthetic
designs
based
on
have
potential
afford
complex
polycyclic
carbon
skeletons
with
impressive
efficiency,
which
are
value
total
synthesis.
International Journal of Molecular Sciences,
Год журнала:
2020,
Номер
21(20), С. 7777 - 7777
Опубликована: Окт. 21, 2020
Brain-derived
neurotrophic
factor
(BDNF)
is
one
of
the
most
distributed
and
extensively
studied
neurotrophins
in
mammalian
brain.
BDNF
signals
through
tropomycin
receptor
kinase
B
(TrkB)
low
affinity
p75
neurotrophin
(p75NTR).
plays
an
important
role
proper
growth,
development,
plasticity
glutamatergic
GABAergic
synapses
modulation
neuronal
differentiation,
it
influences
serotonergic
dopaminergic
neurotransmission.
acts
as
paracrine
autocrine
factor,
on
both
pre-synaptic
post-synaptic
target
sites.
It
crucial
transformation
synaptic
activity
into
long-term
memories.
considered
instructive
mediator
functional
structural
central
nervous
system
(CNS),
influencing
dendritic
spines
and,
at
least
hippocampus,
adult
neurogenesis.
Changes
rate
neurogenesis
spine
density
can
influence
several
forms
learning
memory
contribute
to
depression-like
behaviors.
The
possible
roles
highlighted
this
review
focus
effect
antidepressant
therapies
BDNF-mediated
plasticity.
Moreover,
we
will
data
that
illustrate
a
potent
protective
able
confer
protection
against
neurodegeneration,
particular
Alzheimer’s
disease.
Finally,
give
evidence
how
involvement
pathogenesis
brain
glioblastoma
has
emerged,
thus
opening
new
avenues
for
treatment
deadly
cancer.
Molecular Neurobiology,
Год журнала:
2018,
Номер
56(5), С. 3295 - 3312
Опубликована: Авг. 17, 2018
Brain-derived
neurotrophic
factor
(BDNF)
is
one
of
the
most
studied
neurotrophins
in
healthy
and
diseased
brain.
As
a
result,
there
large
body
evidence
that
associates
BDNF
with
neuronal
maintenance,
survival,
plasticity,
neurotransmitter
regulation.
Patients
psychiatric
neurodegenerative
disorders
often
have
reduced
concentrations
their
blood
A
current
hypothesis
suggests
these
abnormal
levels
might
be
due
to
chronic
inflammatory
state
brain
certain
disorders,
as
neuroinflammation
known
affect
several
BDNF-related
signaling
pathways.
Activation
glia
cells
can
induce
an
increase
pro-
antiinflammatory
cytokines
reactive
oxygen
species,
which
lead
modulation
function
neurotoxicity
observed
pathologies.
Understanding
how
involved
brain,
especially
disease
onset
progression,
crucial
for
development
new
strategies
treatment.
Despite
increasing
involvement
scarce
addresses
interaction
between
neurotrophin
diseases.
This
review
focuses
on
effect
acute
inflammation
common
aims
shed
some
light
possible
biological
mechanisms
may
influence
this
effect.
In
addition,
will
address
behavior
pharmacological
interventions
disorders.
