Can physical exercise in old age improve memory and hippocampal function? DOI Creative Commons
Emrah Düzel, Henriette van Praag, Michael Sendtner

и другие.

Brain, Год журнала: 2016, Номер 139(3), С. 662 - 673

Опубликована: Фев. 11, 2016

Physical exercise can convey a protective effect against cognitive decline in ageing and Alzheimer's disease. While the long-term health-promoting effects of are encouraging, it's potential to induce neuronal vascular plasticity brain is still poorly understood. It remains unclear whether slows trajectory normal by modifying metabolic risk factors and/or consistently boosts function inducing structural neurochemical changes hippocampus related medial temporal lobe circuitry—brain areas that important for learning memory. Hence, it be established what extent interventions old age improve above beyond preservation function. Existing data suggest trials aiming improvement may require different outcome measures balance between two depend on intensity duration, presence preclinical disease pathology, genetic variability. activity offer protection neurodegenerative diseases, but or unclear. Duzel et al. examine evidence improves hippocampal discuss avenues future research.

Язык: Английский

The Central Nervous System and the Gut Microbiome DOI Creative Commons
Gil Sharon, Timothy R. Sampson, Daniel H. Geschwind

и другие.

Cell, Год журнала: 2016, Номер 167(4), С. 915 - 932

Опубликована: Ноя. 1, 2016

Язык: Английский

Процитировано

1260

Exercise Induces Hippocampal BDNF through a PGC-1α/FNDC5 Pathway DOI Creative Commons
Christiane D. Wrann, James P. White,

John Salogiannnis

и другие.

Cell Metabolism, Год журнала: 2013, Номер 18(5), С. 649 - 659

Опубликована: Окт. 10, 2013

Язык: Английский

Процитировано

1134

BDNF: A Key Factor with Multipotent Impact on Brain Signaling and Synaptic Plasticity DOI Creative Commons
Przemysław Kowiański, Grażyna Lietzau, Ewelina Czuba

и другие.

Cellular and Molecular Neurobiology, Год журнала: 2017, Номер 38(3), С. 579 - 593

Опубликована: Июнь 16, 2017

Brain-derived neurotrophic factor (BDNF) is one of the most widely distributed and extensively studied neurotrophins in mammalian brain. Among its prominent functions, can mention control neuronal glial development, neuroprotection, modulation both short- long-lasting synaptic interactions, which are critical for cognition memory. A wide spectrum processes controlled by BDNF, sometimes contradictory effects action be explained based on specific pattern synthesis, comprising several intermediate biologically active isoforms that bind to different types receptor, triggering signaling pathways. The functions BDNF must discussed close relation stage brain cellular components nervous tissue, as well molecular mechanisms signal transduction activated under physiological pathological conditions. In this review, we briefly summarize current state knowledge regarding impact regulation neurophysiological processes. importance future studies aimed at disclosing activation pathways, neuro- gliogenesis, plasticity highlighted.

Язык: Английский

Процитировано

1114

Photochemical Approaches to Complex Chemotypes: Applications in Natural Product Synthesis DOI Creative Commons
Markus D. Kärkäs, John A. Porco, Corey R. J. Stephenson

и другие.

Chemical Reviews, Год журнала: 2016, Номер 116(17), С. 9683 - 9747

Опубликована: Апрель 27, 2016

The use of photochemical transformations is a powerful strategy that allows for the formation high degree molecular complexity from relatively simple building blocks in single step. A central feature all light-promoted involvement electronically excited states, generated upon absorption photons. This produces transient reactive intermediates and significantly alters reactivity chemical compound. input energy provided by light thus offers means to produce strained unique target compounds cannot be assembled using thermal protocols. review aims at highlighting as tool rapidly accessing structurally stereochemically diverse scaffolds. Synthetic designs based on have potential afford complex polycyclic carbon skeletons with impressive efficiency, which are value total synthesis.

Язык: Английский

Процитировано

898

BDNF – a key transducer of antidepressant effects DOI
Carl Björkholm, Lisa M. Monteggia

Neuropharmacology, Год журнала: 2015, Номер 102, С. 72 - 79

Опубликована: Ноя. 11, 2015

Язык: Английский

Процитировано

838

Neurotrophic Factor BDNF, Physiological Functions and Therapeutic Potential in Depression, Neurodegeneration and Brain Cancer DOI Open Access
Luca Colucci-D’Amato, Luisa Speranza, Floriana Volpicelli

и другие.

International Journal of Molecular Sciences, Год журнала: 2020, Номер 21(20), С. 7777 - 7777

Опубликована: Окт. 21, 2020

Brain-derived neurotrophic factor (BDNF) is one of the most distributed and extensively studied neurotrophins in mammalian brain. BDNF signals through tropomycin receptor kinase B (TrkB) low affinity p75 neurotrophin (p75NTR). plays an important role proper growth, development, plasticity glutamatergic GABAergic synapses modulation neuronal differentiation, it influences serotonergic dopaminergic neurotransmission. acts as paracrine autocrine factor, on both pre-synaptic post-synaptic target sites. It crucial transformation synaptic activity into long-term memories. considered instructive mediator functional structural central nervous system (CNS), influencing dendritic spines and, at least hippocampus, adult neurogenesis. Changes rate neurogenesis spine density can influence several forms learning memory contribute to depression-like behaviors. The possible roles highlighted this review focus effect antidepressant therapies BDNF-mediated plasticity. Moreover, we will data that illustrate a potent protective able confer protection against neurodegeneration, particular Alzheimer’s disease. Finally, give evidence how involvement pathogenesis brain glioblastoma has emerged, thus opening new avenues for treatment deadly cancer.

Язык: Английский

Процитировано

676

BDNF-based synaptic repair as a disease-modifying strategy for neurodegenerative diseases DOI
Bai Lu,

Guhan Nagappan,

Xiao-Ming Guan

и другие.

Nature reviews. Neuroscience, Год журнала: 2013, Номер 14(6), С. 401 - 416

Опубликована: Май 15, 2013

Язык: Английский

Процитировано

674

Serum BDNF concentrations as peripheral manifestations of depression: evidence from a systematic review and meta-analyses on 179 associations (N=9484) DOI Open Access
Marc L. Molendijk, Philip Spinhoven, M. Polak

и другие.

Molecular Psychiatry, Год журнала: 2013, Номер 19(7), С. 791 - 800

Опубликована: Авг. 20, 2013

Язык: Английский

Процитировано

621

Brain-Derived Neurotrophic Factor in Brain Disorders: Focus on Neuroinflammation DOI Creative Commons
Bruno Lima Giacobbo, Janine Doorduin, Hans Klein

и другие.

Molecular Neurobiology, Год журнала: 2018, Номер 56(5), С. 3295 - 3312

Опубликована: Авг. 17, 2018

Brain-derived neurotrophic factor (BDNF) is one of the most studied neurotrophins in healthy and diseased brain. As a result, there large body evidence that associates BDNF with neuronal maintenance, survival, plasticity, neurotransmitter regulation. Patients psychiatric neurodegenerative disorders often have reduced concentrations their blood A current hypothesis suggests these abnormal levels might be due to chronic inflammatory state brain certain disorders, as neuroinflammation known affect several BDNF-related signaling pathways. Activation glia cells can induce an increase pro- antiinflammatory cytokines reactive oxygen species, which lead modulation function neurotoxicity observed pathologies. Understanding how involved brain, especially disease onset progression, crucial for development new strategies treatment. Despite increasing involvement scarce addresses interaction between neurotrophin diseases. This review focuses on effect acute inflammation common aims shed some light possible biological mechanisms may influence this effect. In addition, will address behavior pharmacological interventions disorders.

Язык: Английский

Процитировано

614

BDNF-induced local protein synthesis and synaptic plasticity DOI
Graciano Leal,

Diogo Comprido,

Carlos B. Duarte

и другие.

Neuropharmacology, Год журнала: 2013, Номер 76, С. 639 - 656

Опубликована: Апрель 17, 2013

Язык: Английский

Процитировано

609