The Physiology, Signaling, and Pharmacology of Dopamine Receptors

Pharmacological Reviews, Год журнала: 2011, Номер 63(1), С. 182 - 217

Опубликована: Фев. 8, 2011

G protein-coupled dopamine receptors (D1, D2, D3, D4, and D5) mediate all of the physiological functions catecholaminergic neurotransmitter dopamine, ranging from voluntary movement reward to hormonal regulation hypertension. Pharmacological agents targeting dopaminergic neurotransmission have been clinically used in management several neurological psychiatric disorders, including Parkinson9s disease, schizophrenia, bipolar disorder, Huntington9s attention deficit hyperactivity disorder (ADHD¹), Tourette9s syndrome. Numerous advances occurred understanding general structural, biochemical, functional properties that led development multiple pharmacologically active compounds directly target receptors, such as antiparkinson drugs antipsychotics. Recent progress complex biology receptor-related signal transduction mechanisms has revealed that, addition their primary action on cAMP-mediated signaling, can act through diverse signaling involve alternative protein coupling or protein-independent via interactions with ion channels proteins are characteristically implicated receptor desensitization, β-arrestins. One future directions managing dopamine-related pathologic conditions may a transition approaches affect function precise postreceptor intracellular modalities either ligand-biased pharmacology. In this comprehensive review, we discuss classification, basic structural genetic organization, distribution brain periphery, mechanisms. addition, abnormalities expression, function, documented human disorders current pharmacology emerging trends novel therapeutic at and/or related events.

Язык: Английский

---

Global Epigenomic Reconfiguration During Mammalian Brain Development

Science, Год журнала: 2013, Номер 341(6146)

Опубликована: Июль 5, 2013

Epigenetic Brainscape modifications and their potential changes during development are of high interest, but few studies have characterized such differences. Lister et al. ( 1237905 , published online 4 July; see the Perspective by Gabel Greenberg ) report whole-genome base-resolution analysis DNA cytosine transcriptome in frontal cortex human mouse brains at multiple developmental stages. The high-resolution mapping methylation (5mC) one its oxidation derivatives (5hmC) key stages provides a comprehensive resource covering temporal dynamics these epigenetic neurons compared to glia. data suggest that marks dynamic brain both humans mice.

Язык: Английский

---

Epigenetics and the environment: emerging patterns and implications

Nature Reviews Genetics, Год журнала: 2012, Номер 13(2), С. 97 - 109

Опубликована: Янв. 4, 2012

Язык: Английский

---

The brain reward circuitry in mood disorders

Nature reviews. Neuroscience, Год журнала: 2013, Номер 14(9), С. 609 - 625

Опубликована: Авг. 14, 2013

Язык: Английский

---

Transcriptional and epigenetic mechanisms of addiction

Nature reviews. Neuroscience, Год журнала: 2011, Номер 12(11), С. 623 - 637

Опубликована: Окт. 12, 2011

Язык: Английский

---

Early Life Programming and Neurodevelopmental Disorders

Biological Psychiatry, Год журнала: 2010, Номер 68(4), С. 314 - 319

Опубликована: Авг. 1, 2010

Язык: Английский

---

Distribution, recognition and regulation of non-CpG methylation in the adult mammalian brain

Nature Neuroscience, Год журнала: 2013, Номер 17(2), С. 215 - 222

Опубликована: Дек. 22, 2013

Язык: Английский

---

Essential Role of the Histone Methyltransferase G9a in Cocaine-Induced Plasticity

Science, Год журнала: 2010, Номер 327(5962), С. 213 - 216

Опубликована: Янв. 7, 2010

Cocaine-induced alterations in gene expression cause changes neuronal morphology and behavior that may underlie cocaine addiction. In mice, we identified an essential role for histone 3 lysine 9 (H3K9) dimethylation the dimethyltransferase G9a cocaine-induced structural behavioral plasticity. Repeated administration reduced global levels of H3K9 nucleus accumbens. This reduction methylation was mediated through repression this brain region, which regulated by transcription factor DeltaFosB. Using conditional mutagenesis viral-mediated transfer, found down-regulation increased dendritic spine plasticity accumbens neurons enhanced preference cocaine, thereby establishing a crucial long-term actions cocaine.

Язык: Английский

---

Neuronal activity modifies the DNA methylation landscape in the adult brain

Nature Neuroscience, Год журнала: 2011, Номер 14(10), С. 1345 - 1351

Опубликована: Авг. 28, 2011

Язык: Английский

---

Metabolism and cancer: the circadian clock connection

Nature reviews. Cancer, Год журнала: 2009, Номер 9(12), С. 886 - 896

Опубликована: Ноя. 23, 2009

Язык: Английский

---