Inhibition and impulsivity: Behavioral and neural basis of response control

Progress in Neurobiology, Год журнала: 2013, Номер 108, С. 44 - 79

Опубликована: Июль 13, 2013

Язык: Английский

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Relationships between Pupil Diameter and Neuronal Activity in the Locus Coeruleus, Colliculi, and Cingulate Cortex

Neuron, Год журнала: 2015, Номер 89(1), С. 221 - 234

Опубликована: Дек. 18, 2015

Язык: Английский

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An opportunity cost model of subjective effort and task performance

Behavioral and Brain Sciences, Год журнала: 2013, Номер 36(6), С. 661 - 679

Опубликована: Дек. 1, 2013

Abstract Why does performing certain tasks cause the aversive experience of mental effort and concomitant deterioration in task performance? One explanation posits a physical resource that is depleted over time. We propose an alternative centers on representations costs benefits associated with performance. Specifically, computational mechanisms, especially those executive function, can be deployed for only limited number simultaneous at any given moment. Consequently, deployment these mechanisms carries opportunity cost – is, next-best use to which systems might put. argue phenomenology understood as felt output cost/benefit computations. In turn, subjective motivates reduced service present task. These representations, then, together other calculations, determine expended and, everything else equal, result performance reductions. making our case this position, we review explanations both reductions Likewise, broad range relevant empirical results from across sub-disciplines, psychology neuroscience. hope proposal will help build links among diverse fields have been addressing similar questions different perspectives, emphasize ways models empirically distinguished.

Язык: Английский

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Selective neuronal vulnerability in Parkinson disease

Nature reviews. Neuroscience, Год журнала: 2017, Номер 18(2), С. 101 - 113

Опубликована: Янв. 20, 2017

Язык: Английский

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Dynamic adaptation of large-scale brain networks in response to acute stressors

Trends in Neurosciences, Год журнала: 2014, Номер 37(6), С. 304 - 314

Опубликована: Апрель 21, 2014

Язык: Английский

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Pupil diameter covaries with BOLD activity in human locus coeruleus

Human Brain Mapping, Год журнала: 2014, Номер 35(8), С. 4140 - 4154

Опубликована: Фев. 7, 2014

Abstract The locus coeruleus‐noradrenergic (LC–NA) neuromodulatory system has been implicated in a broad array of cognitive processes, yet scope for investigating this system's function humans is currently limited by an absence reliable non‐invasive measures LC activity. Although pupil diameter employed as proxy measure activity numerous studies, empirical evidence relationship between the two lacking. In present study, we sought to rigorously probe and BOLD localized human LC. Simultaneous pupillometry fMRI revealed continuous dorsal pontine cluster overlapping with LC, via neuromelanin‐sensitive structural imaging atlas. This was both at rest during performance two‐stimulus oddball task, without spatial smoothing data, survived retrospective image correction physiological noise. Furthermore, extent pupil/LC guided volume‐of‐interest analysis which provide first demonstration fundamental characteristic animal activity: phasic modulation stimulus relevance. Taken together, these findings highlight potential utilizing achieve more comprehensive understanding role LC–NA cognition. Hum Brain Mapp 35:4140–4154, 2014 . © Wiley Periodicals, Inc

Язык: Английский

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Viral-genetic tracing of the input–output organization of a central noradrenaline circuit

Nature, Год журнала: 2015, Номер 524(7563), С. 88 - 92

Опубликована: Июль 1, 2015

Язык: Английский

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Norepinephrine ignites local hotspots of neuronal excitation: How arousal amplifies selectivity in perception and memory

Behavioral and Brain Sciences, Год журнала: 2015, Номер 39

Опубликована: Июль 1, 2015

Abstract Emotional arousal enhances perception and memory of high-priority information but impairs processing other information. Here, we propose that, under arousal, local glutamate levels signal the current strength a representation interact with norepinephrine (NE) to enhance high priority representations out-compete or suppress lower representations. In our "glutamate amplifies noradrenergic effects" (GANE) model, at site prioritized increases NE release from locus coeruleus (LC) generate “NE hotspots.” At these hotspots, are mutually enhancing amplify activation contrast, arousal-induced LC activity inhibits less active via two mechanisms: 1) Where there lateral inhibition is amplified; 2) no hotspots emerge, only enough activate low-threshold inhibitory adrenoreceptors. Thus, promotes few excitation in context widespread suppression, while suppressing rest. Hotspots also help synchronize oscillations across neural ensembles transmitting Furthermore, brain structures that detect stimulus phasic preferentially route such through large-scale functional networks. A surge before, during, after encoding synaptic plasticity triggering protein synthesis processes selective consolidation. Together, mechanisms promote attention arousal. GANE not reconciles apparently contradictory findings emotion-cognition literature extends previous influential theories neuromodulation by proposing specific for how LC-NE gain.

Язык: Английский

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CRH Engagement of the Locus Coeruleus Noradrenergic System Mediates Stress-Induced Anxiety

Neuron, Год журнала: 2015, Номер 87(3), С. 605 - 620

Опубликована: Июль 23, 2015

Язык: Английский

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Questions and controversies in the study of time-varying functional connectivity in resting fMRI

Network Neuroscience, Год журнала: 2019, Номер 4(1), С. 30 - 69

Опубликована: Дек. 16, 2019

The brain is a complex, multiscale dynamical system composed of many interacting regions. Knowledge the spatiotemporal organization these interactions critical for establishing solid understanding brain's functional architecture and relationship between neural dynamics cognition in health disease. possibility studying through careful analysis neuroimaging data has catalyzed substantial interest methods that estimate time-resolved fluctuations connectivity (often referred to as "dynamic" or time-varying connectivity; TVFC). At same time, debates have emerged regarding application TVFC analyses resting fMRI data, about statistical validity, physiological origins, cognitive behavioral relevance TVFC. These other unresolved issues complicate interpretation findings limit insights can be gained from this promising new research area. This article brings together scientists with variety perspectives on review current literature light issues. We introduce core concepts, define key terms, summarize controversies open questions, present forward-looking perspective how rigorously productively applied investigate wide range questions systems neuroscience.

Язык: Английский

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