From circuits to behaviour in the amygdala

Nature, Год журнала: 2015, Номер 517(7534), С. 284 - 292

Опубликована: Янв. 13, 2015

Язык: Английский

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The brain reward circuitry in mood disorders

Nature reviews. Neuroscience, Год журнала: 2013, Номер 14(9), С. 609 - 625

Опубликована: Авг. 14, 2013

Язык: Английский

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Pleasure Systems in the Brain

Neuron, Год журнала: 2015, Номер 86(3), С. 646 - 664

Опубликована: Май 1, 2015

Язык: Английский

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Adult hippocampal neurogenesis and cognitive flexibility — linking memory and mood

Nature reviews. Neuroscience, Год журнала: 2017, Номер 18(6), С. 335 - 346

Опубликована: Май 4, 2017

Язык: Английский

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The Nucleus Accumbens: An Interface Between Cognition, Emotion, and Action

Annual Review of Psychology, Год журнала: 2014, Номер 66(1), С. 25 - 52

Опубликована: Сен. 24, 2014

Nearly 40 years of research on the function nucleus accumbens (NAc) has provided a wealth information its contributions to behavior but also yielded controversies and misconceptions regarding these functions. A primary tenet this review is that, rather than serving as "reward" center, NAc plays key role in action selection, integrating cognitive affective processed by frontal temporal lobe regions augment efficiency vigor appetitively or aversively motivated behaviors. Its involvement functions most prominent when appropriate course ambiguous, uncertain, laden with distractors, state flux. To end, different subregions play dissociable roles refining promoting approach toward motivationally relevant stimuli, suppressing inappropriate actions so that goals may be obtained more efficiently, encoding outcomes guide direction subsequent ones.

Язык: Английский

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Resolving the neural circuits of anxiety

Nature Neuroscience, Год журнала: 2015, Номер 18(10), С. 1394 - 1404

Опубликована: Сен. 25, 2015

Язык: Английский

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Memory Engram Cells Have Come of Age

Neuron, Год журнала: 2015, Номер 87(5), С. 918 - 931

Опубликована: Сен. 1, 2015

Язык: Английский

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Anxiety Cells in a Hippocampal-Hypothalamic Circuit

Neuron, Год журнала: 2018, Номер 97(3), С. 670 - 683.e6

Опубликована: Янв. 31, 2018

Язык: Английский

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The Nucleus Accumbens: Mechanisms of Addiction across Drug Classes Reflect the Importance of Glutamate Homeostasis

Pharmacological Reviews, Год журнала: 2016, Номер 68(3), С. 816 - 871

Опубликована: Июнь 30, 2016

The nucleus accumbens is a major input structure of the basal ganglia and integrates information from cortical limbic structures to mediate goal-directed behaviors. Chronic exposure several classes drugs abuse disrupts plasticity in this region, allowing drug-associated cues engender pathologic motivation for drug seeking. A number alterations glutamatergic transmission occur within after withdrawal chronic exposure. These drug-induced neuroadaptations serve as molecular basis relapse vulnerability. In review, we focus on role that glutamate signal transduction plays addiction-related First, explore accumbens, including cell types neuronal populations present well afferent efferent connections. Next discuss rodent models addiction assess viability these testing candidate pharmacotherapies prevention relapse. Then provide review literature describing how synaptic altered also pharmacological manipulation systems can inhibit seeking laboratory setting. Finally, examine results clinical trials which designed manipulate have been effective treating human patients. Further elucidation alter will be necessary development new therapeutics treatment across all addictive substances.

Язык: Английский

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Striatal circuits for reward learning and decision-making

Nature reviews. Neuroscience, Год журнала: 2019, Номер 20(8), С. 482 - 494

Опубликована: Июнь 6, 2019

Язык: Английский

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